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5-chloro-7-nitroquinolin-8-ol (CID 260645) - Compound BioActivity Data
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BioActivity Outcomes:
Active(66)
 
 
Inactive(653)
 
 
Inconclusive(42)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(19)
 
 
 
Bcl-2 like(11)
 
 
G-alpha(10)
 
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(497)
 
 
 
 
Confirmatory(229)
 
 
 
 
 
Literature(10)
 
 
 
BioActivity Types:
Potency(153)
 
 
 
 
 
IC50(43)
 
 
 
 
EC50(26)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 689    Data Row: 767   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24782524]
EC50 0.084Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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2
[SID24782524]
EC50 0.291Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole [AID2423, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
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3
[SID24782524]
EC50_MICROM 0.859Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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4
[SID24782524]
IC50 1.46A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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5
[SID24782524]
IC50 1.62A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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6
[SID24782524]
IC50 1.96A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
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7
[SID24782524]
Potency 2.5929A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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8
[SID24782524]
Potency 2.8184qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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9
[SID24782524]
IC50 3.05A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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10
[SID24782524]
IC50 3.07A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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11
[SID24782524]
EC50 3.668Luminesence Cell-Based Secondary Assay to Identify Inhibitors of Hsp90 [AID2400, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
View
12
[SID24782524]
Potency 3.9811VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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13
[SID24782524]
IC50 4.25A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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14
[SID24782524]
Potency 10qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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15
[SID24782524]
EC50 11.112Fluorescence Cell-Based Secondary Assay for toxicity in mammalian fibroblasts [AID2327, Type: confirmatory]
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16
[SID24782524]
Potency 11.2202qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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17
[SID24782524]
Potency 12.5893qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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18
[SID24782524]
EC50_MICROM 12.99Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits [AID2740, Type: confirmatory]RPL19A [Saccharomyces cerevisiae] [gi:536029]
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19
[SID24782524]
Potency 17.7828qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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20
[SID24782524]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID24782524]
Potency 19.9526qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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22
[SID24782524]
EC50 23.874Fluorescence Cell-Based Secondary Assay to Measure Toxicity of Compounds Not in the Presence of Fluconazole [AID2387, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
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23
[SID92126104]
EC50_MICROM 27.17Confirmatory Primary Screen Hits KU SAR Dose Response Multiplex in TOR pathway GFP-fusion proteins for Saccharomyes cerevisiae, specifically RPL19A [AID488808, Type: confirmatory]RPL19A [Saccharomyces cerevisiae] [gi:536029]
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24
[SID24782524]
EC50 27.7A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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25
[SID24782524]
Potency 28.1838qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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26
[SID24782524]
EC50 28.73A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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27
[SID24782524]
Potency 31.6228qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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28
[SID24782524]
Potency 35.4813qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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29
[SID24782524]
Counterscreen for inhibitors of RecBCD: Absorbance-based cell-based high throughput assay to identify inhibitors of bacterial viability [AID651983, Type: screening]
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30
[SID24782524]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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31
[SID24782524]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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32
[SID24782524]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID540248, Type: other]HTRA1 protein [gi:121945198]
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33
[SID24782524]
In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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34
[SID24782524]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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35
[SID24782524]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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36
[SID24782524]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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37
[SID24782524]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae, specifically LAP4 Cherry Pick Compounds [AID2271, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
View
38
[SID24782524]
Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compound [AID1979, Type: screening]heat shock protein 90 [Candida albicans] [gi:994798]
View
39
[SID24782524]
qHTS Assay for Inhibitors of the Six1/Eya2 Interaction [AID651725, Type: screening]six1 [Homo sapiens] [gi:1246761]
View
40
[SID24782524]
qHTS Assay for Inhibitors of the CtBP/E1A Interaction [AID651724, Type: screening]CtBP interacting protein CtIP [Homo sapiens] [gi:1730321]
View
41
[SID24782524]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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42
[SID24782524]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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43
[SID24782524]
Second counter screen for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay without carbachol activation [AID493001, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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44
[SID24782524]
Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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45
[SID24782524]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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46
[SID24782524]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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47
[SID24782524]
Counterscreen for RECBCD inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of AddAB recombination protein complex [AID651984, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
View
48
[SID24782524]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
View
49
[SID24782524]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
View
50
[SID24782524]
Counterscreen for RECBCD inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of AddAB recombination protein complex [AID651984, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
View