Carmustine (CID 2578) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(98)
 
 
Inactive(828)
 
 
Inconclusive(79)
 
 
Unspecified(268)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
p450(26)
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
HELICc(8)
 
 
 
NR LBD TR(8)
 
 
 
BioAssay Types:
Confirmatory(460)
 
 
 
 
 
Screening(278)
 
 
Literature(246)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(350)
 
 
 
 
 
IC50(177)
 
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1092    Data Row: 1273   Total Pages: 26   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103173718]
IC50 1.42In vitro inhibitory concentration against growth of U87MG glioblastoma cell line in clonogenic survival assay after 24 hr [AID248624, Type: Literature]
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2
[SID103173718]
IC50 2.37In vitro inhibitory concentration against growth of SNB19 glioblastoma cell line in clonogenic survival assay after 24 hr [AID248623, Type: Literature]
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3
[SID26747453]
Potency 3.1623qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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4
[SID26747453]
Potency 3.1623qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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5
[SID103173718]
ED50 4Compound was tested in vitro for cytotoxicity against L1210 leukemia cells in tumor bearing mice. [AID97975, Type: Literature]
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6
[SID103173718]
ED50 4In vitro inhibitory activity against murine leukemia L1210 cells [AID97982, Type: Literature]
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7
[SID103173718]
IC50 4.5Dose required to inhibit cell growth was determined against L1210 cell line of murine lymphocytotic leukemia [AID96470, Type: Literature]
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8
[SID103173718]
IC50 4.5Evaluated for the inhibitory concentration required to cause growth inhibition of MCF-7 breast cell line using the MTT Cytotoxicity Assay [AID103374, Type: Literature]
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9
[SID103173718]
IC50 5Evaluated for the inhibitory concentration required to cause growth inhibition of H23 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay [AID80645, Type: Literature]
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10
[SID103173718]
IC50 5.9Dose required to inhibit cell growth was determined against P388D1 cell line of murine lymphocytotic leukemia [AID154140, Type: Literature]
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11
[SID103173718]
ED50 6.3Mean value for the exposure for P388 to the drug for a period of 40 min at pH 7.4 and 37 degree [AID152565, Type: Literature]
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12
[SID103173718]
IC50 7Evaluated for the inhibitory concentration required to cause growth inhibition of LOX melanoma cell line using the MTT Cytototoxicity Assay [AID100996, Type: Literature]
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13
[SID103173718]
IC50 7.4Dose required to inhibit cell growth was determined against MDA-MB-231 cell line of human non-hormone dependent breast carcinoma [AID101660, Type: Literature]
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14
[SID103173718]
IC50 8Evaluated for the inhibitory concentration required to cause growth inhibition of A427Mer- cell line of lung using the MTT Cytotoxicity Assay [AID7875, Type: Literature]
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15
[SID103173718]
IC50 8.2Dose required to inhibit cell growth was determined against CHO cell line [AID47684, Type: Literature]
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16
[SID103173718]
IC50 9Dose required to inhibit cell growth was determined against K562 cell line of chronic myelogenous leukemia [AID94466, Type: Literature]
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17
[SID103173718]
IC50 9Evaluated for the inhibitory concentration required to cause growth inhibition of H125 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay [AID80057, Type: Literature]
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18
[SID103173718]
IC50 9.3Cytotoxicity against rat C6 glioma cell line [AID270650, Type: Literature]
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19
[SID103173718]
ED50 13.3Mean value for the exposure for P388 to the drug for a period of 60 min [AID152566, Type: Literature]
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20
[SID103173718]
IC50 15Evaluated for the inhibitory concentration required to cause growth inhibition of OVCAR-3 ovarian cell line using the MTT Cytototoxicity Assay [AID145589, Type: Literature]
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21
[SID103173718]
IC50 15Evaluated for the inhibitory concentration required to cause growth inhibition of U251 cell line of central nervous system (CNS) using the MTT Cytotoxicity Assay [AID214234, Type: Literature]
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22
[SID103173718]
IC50 17Dose required to inhibit cell growth was determined against HT-29 cell line of human adenocarcinoma [AID85435, Type: Literature]
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23
[SID103173718]
IC50 18Evaluated for the inhibitory concentration required to cause growth inhibition of A172Mer- cell line of central nervous system (CNS) using the MTT Cytotoxicity Assay [AID9802, Type: Literature]
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24
[SID103173718]
IC50 18Evaluated for the inhibitory concentration required to cause growth inhibition of OVCAR-4 ovarian cell line using the MTT Cytototoxicity Assay [AID145731, Type: Literature]
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25
[SID103173718]
IC50 20Evaluated for the inhibitory concentration required to cause growth inhibition of H522 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay [AID78556, Type: Literature]
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26
[SID103173718]
IC50 20Evaluated for the inhibitory concentration required to cause growth inhibition of MCF-7ADR breast cell line using the MTT Cytotoxicity Assay [AID103238, Type: Literature]
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27
[SID103173718]
IC50 20Evaluated for the inhibitory concentration required to cause growth inhibition of MALME-3M melanoma cell line using the MTT Cytototoxicity Assay [AID102565, Type: Literature]
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28
[SID103173718]
IC50 25Evaluated for the inhibitory concentration required to cause growth inhibition of TE-671 cell line of central nervous system (CNS)using the MTT Cytotoxicity Assay [AID208864, Type: Literature]
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29
[SID103173718]
IC50 27Evaluated for the inhibitory concentration required to cause growth inhibition of SK-MEL-5 melanoma cell line using the MTT Cytototoxicity Assay [AID202320, Type: Literature]
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30
[SID103173718]
IC50 37Evaluated for the inhibitory concentration required to cause growth inhibition of DOD-1 breast cell line using the MTT Cytototoxicity Assay [AID57527, Type: Literature]
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31
[SID8149911]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH20) [AID1606, Type: other]
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32
[SID48415703]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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33
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Lieberman Plasma Cell No. 1 (LPC-1) (intraperitoneal) in unknown mice [AID344, Type: other]
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34
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Ependymoblastoma (intracerebral) in B6C3F1 mice [AID226, Type: other]
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35
[SID8149911]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH100) [AID1596, Type: other]
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36
[SID8149911]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH016) [AID1608, Type: other]
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37
[SID8149911]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH08) [AID1609, Type: other]
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38
[SID8149911]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells [AID1610, Type: other]
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39
[SID479311]
 NCI Yeast Anticancer Drug Screen. Data for the rad50EPP+ strain [AID151, Type: other]
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40
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Lymphoma AKR (Transplanted) (intraperitoneal) in AKR/Lw mice [AID190, Type: other]
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41
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6D2F1 (BDF1) mice [AID192, Type: other]
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42
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (subcutaneous) in B6D2F1 (BDF1) mice [AID194, Type: other]
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43
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intracerebral) in B6D2F1 (BDF1) mice [AID196, Type: other]
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44
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in C57BL/6 mice [AID198, Type: other]
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45
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6C3F1 mice [AID200, Type: other]
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46
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P288 Lymphocytic Leukemia resistant to methotrexate; NSC 740 (intraperitoneal) in B6D2F1 (BDF1) mice [AID204, Type: other]
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47
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Adenocarcinoma 755 (subcutaneous) in B6D2F1 (BDF1) mice [AID180, Type: other]
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48
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia resistant to Adriamycin; NSC 123127, Developed at Scr 06 and 41 (intraperitoneal) in B6D2F1 (BDF1) mice [AID182, Type: other]
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49
[SID479311]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model ADJ-PC-6 (intraperitoneal) in BALB/cJ mice [AID184, Type: other]
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50
[SID479311]
 NCI Yeast Anticancer Drug Screen. Data for the rad18 strain [AID177, Type: other]
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