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Carmustine (CID 2578) - Compound BioActivity Data
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BioActivity Outcomes:
Active(107)
 
 
Inactive(1026)
 
 
Inconclusive(88)
 
 
Unspecified(744)
 
 
Top Targets:
7TM GPCR Srx(43)
 
 
 
7TM GPCR Srsx(33)
 
 
 
p450(27)
 
 
 
 
NR LBD PPAR(13)
 
 
 
NR LBD ER(12)
 
 
 
 
BioAssay Types:
Confirmatory(704)
 
 
 
 
 
Screening(330)
 
 
Literature(278)
 
 
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Potency(491)
 
 
 
 
 
IC50(180)
 
 
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1717    Data Row: 1965   Total Pages: 99   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144203648]
Potency-Replicate_1 1.1883qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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2
[SID103173718]
IC50 1.42In vitro inhibitory concentration against growth of U87MG glioblastoma cell line in clonogenic survival assay after 24 hr [AID248624, Type: Literature]
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3
[SID103173718]
IC50 2.37In vitro inhibitory concentration against growth of SNB19 glioblastoma cell line in clonogenic survival assay after 24 hr [AID248623, Type: Literature]
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4
[SID26747453]
Potency 3.1623qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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5
[SID103173718]
ED50 4Compound was tested in vitro for cytotoxicity against L1210 leukemia cells in tumor bearing mice. [AID97975, Type: Literature]
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6
[SID103173718]
ED50 4In vitro inhibitory activity against murine leukemia L1210 cells [AID97982, Type: Literature]
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7
[SID103173718]
IC50 4.5Dose required to inhibit cell growth was determined against L1210 cell line of murine lymphocytotic leukemia [AID96470, Type: Literature]
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8
[SID103173718]
IC50 4.5Evaluated for the inhibitory concentration required to cause growth inhibition of MCF-7 breast cell line using the MTT Cytotoxicity Assay [AID103374, Type: Literature]
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9
[SID103173718]
EC50 4.8Cytotoxicity against Rattus norvegicus (rat) C6 cells after 4 days by cresylecth violet-staining method [AID1083530, Type: confirmatory]
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10
[SID103173718]
IC50 5Evaluated for the inhibitory concentration required to cause growth inhibition of H23 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay [AID80645, Type: Literature]
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11
[SID103173718]
IC50 5.9Dose required to inhibit cell growth was determined against P388D1 cell line of murine lymphocytotic leukemia [AID154140, Type: Literature]
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12
[SID103173718]
ED50 6.3Mean value for the exposure for P388 to the drug for a period of 40 min at pH 7.4 and 37 degree [AID152565, Type: Literature]
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13
[SID103173718]
IC50 7Evaluated for the inhibitory concentration required to cause growth inhibition of LOX melanoma cell line using the MTT Cytotoxicity Assay [AID100996, Type: Literature]
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14
[SID103173718]
IC50 7.4Dose required to inhibit cell growth was determined against MDA-MB-231 cell line of human non-hormone dependent breast carcinoma [AID101660, Type: Literature]
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15
[SID170464880]
Ratio Potency (uM) 7.49722qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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16
[SID103173718]
IC50 8Evaluated for the inhibitory concentration required to cause growth inhibition of A427Mer- cell line of lung using the MTT Cytotoxicity Assay [AID7875, Type: Literature]
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17
[SID103173718]
IC50 8.1Inhibition of human recombinant glutathione reductase using glutathione as substrate preincubated for 30 mins by colorimetric assay [AID1062975, Type: Literature]Glutathione reductase, mitochondrial [gi:14916998]
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18
[SID103173718]
IC50 8.2Dose required to inhibit cell growth was determined against CHO cell line [AID47684, Type: Literature]
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19
[SID103173718]
IC50 9Evaluated for the inhibitory concentration required to cause growth inhibition of H125 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay [AID80057, Type: Literature]
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20
[SID103173718]
IC50 9Dose required to inhibit cell growth was determined against K562 cell line of chronic myelogenous leukemia [AID94466, Type: Literature]
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