mecarzole (CID 25429) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(32)
 
 
Inactive(424)
 
 
Inconclusive(32)
 
 
Unspecified(57)
 
 
Top Targets:
NR LBD PPAR(10)
 
 
 
7TM GPCR Srx(9)
 
 
NR LBD TR(8)
 
 
 
BRLZ(5)
 
 
 
 
7TM GPCR Srsx(5)
 
 
BioAssay Types:
Confirmatory(286)
 
 
 
 
 
Screening(160)
 
 
Literature(67)
 
 
 
 
BioActivity Types:
Potency(186)
 
 
 
 
 
IC50(11)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 502    Data Row: 545   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103267651]
IC50 0.057The compound was tested in vitro against the protozoa Giardia lamblia, for the inhibition of tubulin polymerization in rat brain [AID75268, Type: Literature]
View
2
[SID103267651]
IC50 0.057Antiparasitic activity against Giardia duodenalis IMSS:0989 after 48 hrs [AID658931, Type: Literature]
View
3
[SID103267651]
IC50 0.204The compound was tested in vitro against the protozoa Entamoeba histolytica, for the inhibition of tubulin polymerization in rat brain [AID67529, Type: Literature]
View
4
[SID103267651]
IC50 2.6Antifungal activity against Fusarium nivale CGMCC 3.4600 after 48 hrs by Alamar blue assay [AID478715, Type: Literature]
View
5
[SID103267651]
IC50 5Antifungal activity against Pyricularia oryzae CGMCC 3.3283 after 48 hrs by Alamar blue assay [AID478716, Type: Literature]
View
6
[SID92763967]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
View
7
[SID92763967]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
View
8
[SID17389123]
Potency 10qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
View
9
[SID17389123]
Potency 10qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
10
[SID17389123]
Potency 10qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
11
[SID17389123]
Potency 10qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
12
[SID17389123]
Potency 10qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
13
[SID26752754]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
14
[SID26752754]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
15
[SID26752754]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
16
[SID26752754]
Potency 12.5893qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
17
[SID26752754]
Potency 50.1187qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
View
18
[SID26752754]
Potency 61.1306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
View
19
[SID26752754]
Potency 61.1306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
View
20
[SID26752754]
Potency 61.1306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
View
21
[SID26752754]
Potency 61.1306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
View
22
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
View
23
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
View
24
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
View
25
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
View
26
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
View
27
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
View
28
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
View
29
[SID26752754]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
View
30
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
View
31
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
View
32
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
View
33
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
View
34
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
View
35
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
View
36
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
View
37
[SID17389123]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
View
38
[SID17389123]
 Cell Viability - Jurkat [AID426, Type: confirmatory]
View
39
[SID17389123]
 Cell Viability - NIH 3T3 [AID541, Type: confirmatory]
View
40
[SID17389123]
 Cell Viability - H-4-II-E [AID543, Type: confirmatory]
View
41
[SID17389123]
 Cell Viability - SH-SY5Y [AID544, Type: confirmatory]
View
42
[SID103267651]
IC50 10Inhibition of Co2+ loaded MetAP expressed in Escherichia coli [AID259066, Type: Literature]
View
43
[SID92763967]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
44
[SID92763967]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
45
[SID103267651]
 Inhibition of Co2+ loaded MetAP expressed in Escherichia coli at 10 uM [AID259068, Type: Literature]
View
46
[SID103267651]
 Antifungal activity against Glomerella cingulata at 1 ug/mL by disc diffusion method [AID286222, Type: Literature]
View
47
[SID103267651]
 Antifungal activity against Peronophythora litchii at 1 ug/mL by disc diffusion method [AID286223, Type: Literature]
View
48
[SID103267651]
 Antifungal activity against Glorosprium musarum at 1 ug/mL by disc diffusion method [AID286224, Type: Literature]
View
49
[SID103267651]
 Antifungal activity against Aspergillus flavus at 0.5% (w/v) concentration by disc diffusion method [AID294743, Type: Literature]
View
50
[SID103267651]
 Antifungal activity against Aspergillus flavus at 1% (w/v) concentration by disc diffusion method [AID294744, Type: Literature]
View