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7-aminoquinoline-5,8-dione (CID 253688) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(7)
 
 
Unspecified(22)
 
 
Top Targets:
PAD(13)
 
 
 
 
PAD M(4)
 
 
BioAssay Types:
Literature(29)
 
 
 
 
Confirmatory(5)
 
 
BioActivity Types:
IC50(8)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 35    Data Row: 47   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245979]
IC50 0.17Inhibition of recombinant wild-type PAD3 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069620, Type: Literature]Protein-arginine deiminase type-3 [gi:56757696]
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2
[SID118043674]
Average IC50 [PAD3] 0.17Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 14 against PAD1-4 [AID588472_3, Type: confirmatory]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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3
[SID103245979]
IC50 0.74Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069621, Type: Literature]Protein-arginine deiminase type-2 [gi:7531171]
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4
[SID118043674]
Average IC50 [PAD2] 0.74Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 14 against PAD1-4 [AID588472_2, Type: confirmatory]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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5
[SID103245979]
EC50 0.8Cytotoxicity against human U2OS cells after 3 days by XTT-PMS assay [AID1069594, Type: Literature]
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6
[SID103245979]
IC50 0.96Inhibition of recombinant wild-type PAD1 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069622, Type: Literature]Protein-arginine deiminase type-1 [gi:56757695]
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7
[SID118043674]
Average IC50 [PAD1] 0.97Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 14 against PAD1-4 [AID588472_1, Type: confirmatory]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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8
[SID118043674]
Average IC50 [PAD4] 1Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 14 against PAD1-4 [AID588472_4, Type: confirmatory]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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9
[SID103245979]
IC50 1Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069619, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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10
[SID103245979]
EC50 1.1Cytotoxicity against mouse NIH/3T3 cells after 3 days by XTT-PMS assay [AID1069593, Type: Literature]
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11
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to identify inhibitors of PAD4 [AID588559, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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12
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_4, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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13
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PAD4 [AID651627, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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14
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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15
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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16
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 14 against PAD1-4 [AID588472, Type: confirmatory]
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17
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560, Type: other]
View
18
[SID118043674]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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19
[SID103245979]
Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate assessed as residual activity at 10 uM preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay relative to control [AID1069623, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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20
[SID103245979]
Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability at 10 uM after 3 days by XTT-PMS assay relative to control [AID1069595, Type: Literature]
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