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Caffeine (CID 2519) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(117)
 
 
Inactive(1394)
 
 
Inconclusive(106)
 
 
Unspecified(1825)
 
 
Top Targets:
7TM GPCR Srsx(103)
 
 
 
 
 
7TM GPCR Srx(45)
 
 
 
 
p450(27)
 
 
 
 
 
NR LBD TR(26)
 
 
 
NR LBD PPAR(26)
 
 
 
BioAssay Types:
Confirmatory(858)
 
 
 
 
 
Literature(477)
 
 
 
 
 
Screening(429)
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(757)
 
 
 
 
 
IC50(189)
 
 
 
 
Ki(105)
 
 
 
EC50(7)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2891    Data Row: 3442   Total Pages: 69   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178995]
IC50 4.89779Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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2
[SID103178995]
Ki 5.01187Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method [AID607198, Type: Literature]Adenosine receptor A2a [gi:543740]
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3
[SID144208883]
Ratio Potency (uM) 8.09465qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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4
[SID103178995]
Ki 9.4Displacement of [3H]CGS21680 from adenosine A2A receptor in rat brain striatal membrane [AID400072, Type: Literature]Adenosine receptor A2a [gi:8928539]
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5
[SID103178995]
Ki 10.2Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
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6
[SID103178995]
Ki 10.4Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand [AID33176, Type: Literature]
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7
[SID103178995]
Ki 10.4Antagonist activity against human adenosine A2B receptor [AID494495, Type: Literature]Adenosine receptor A2b [gi:112938]
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8
[SID103178995]
Ki 10.4Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells [AID372174, Type: Literature]Adenosine receptor A2b [gi:112938]
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9
[SID103178995]
Ki 13.3Binding affinity against human recombinant Adenosine A3 receptor stably expressed in HEK293 cells by displacing [125I]AB-MECA radioligand [AID34580, Type: Literature]
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10
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A2b [gi:112939]
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11
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A3 [gi:2506479]
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12
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A2a [gi:8928539]
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13
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A1 [gi:2827766]
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14
[SID103178995]
Ki 16Ability to inhibit binding of [3H]NECA to Adenosine A2A receptor in rat brain striatal membranes [AID35014, Type: Literature]
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15
[SID103178995]
Ki 17Displacement of [3H]CHA from adenosine A1 receptor in rat brain cortical membrane [AID400069, Type: Literature]Adenosine receptor A1 [gi:2827766]
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16
[SID103178995]
Ki 18.1Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells [AID320106, Type: Literature]Adenosine receptor A2a [gi:543740]
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17
[SID103178995]
Ki 18.1Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells by scintillation counting [AID427643, Type: Literature]Adenosine receptor A2a [gi:543740]
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18
[SID103178995]
Ki 18.1Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293T cells [AID381813, Type: Literature]Adenosine receptor A2a [gi:543740]
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19
[SID103178995]
Ki 18.8Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane [AID307859, Type: Literature]Adenosine receptor A1 [gi:2827766]
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20
[SID103178995]
Ki 18.8Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane [AID691848, Type: Literature]Adenosine receptor A1 [gi:2827766]
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21
[SID103178995]
Ki 18.8Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane [AID301667, Type: Literature]Adenosine receptor A1 [gi:2827766]
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22
[SID103178995]
IC50 20.472DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2a [gi:543740]
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23
[SID103178995]
Ki 20.5Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells [AID692488, Type: Literature]Adenosine receptor A2b [gi:112938]
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24
[SID103178995]
Ki 22Displacement of [3H]NECA from Sprague-Dawley rat adenosine A2A receptor by scintillation counting [AID387203, Type: Literature]Adenosine receptor A2a [gi:8928539]
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25
[SID103178995]
Ki 22Ability to inhibit binding of [3H]-CGS- 21680 to adenosine A2A receptor in rat brain striatal membranes. [AID35013, Type: Literature]
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26
[SID103178995]
Ki 23Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680 [AID32862, Type: Literature]
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27
[SID103178995]
Ki 23.4Displacement of [3H]MSX-2 from human recombinant adenosine A2A receptor expressed in CHO cells [AID692486, Type: Literature]Adenosine receptor A2a [gi:543740]
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28
[SID103178995]
Ki 23.5Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane by liquid scintillation counting [AID336455, Type: Literature]Adenosine receptor A1 [gi:2827766]
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29
[SID144208883]
Potency-Replicate_1 24.6338qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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30
[SID103178995]
Ki 25Antagonist binding of L-N6-phenyl-isopropyl)-[3H]adenosine to rat brain [AID195543, Type: Literature]Adenosine receptor A1 [gi:2827766]
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31
[SID103178995]
Ki 25Antagonist binding of L-N6-phenyl-isopropyl)-[3H]adenosine to rat brain [AID195543, Type: Literature]Adenosine receptor A2a [gi:8928539]
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32
[SID103178995]
Ki 25Antagonist binding of L-N6-phenyl-isopropyl)-[3H]adenosine to rat brain [AID195543, Type: Literature]Adenosine receptor A2b [gi:112939]
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33
[SID103178995]
Ki 25Antagonist binding of L-N6-phenyl-isopropyl)-[3H]adenosine to rat brain [AID195543, Type: Literature]Adenosine receptor A3 [gi:2506479]
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34
[SID103178995]
Ki 26Ability to inhibit binding of [3H]CHA to adenosine A1 receptor in rat brain cortical membranes. [AID31709, Type: Literature]
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35
[SID103178995]
Ki 27Binding affinity against adenosine A2 receptor from rat striatal membranes, using N-[3H]-ethyladenosin-5''-uronamide as radioligand (in the presence of 50 nM cyclopentyl adenosine). [AID30810, Type: Literature]
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36
[SID103178995]
Ki 27Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes. [AID33563, Type: Literature]
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37
[SID103178995]
Ki 27Binding affinity at Adenosine A2 receptor from rat striatal membranes by N-[3H] ethyladenosin-5'- uronamide displacement. [AID33740, Type: Literature]
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38
[SID103178995]
Ki 27Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine [AID33587, Type: Literature]
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39
[SID103178995]
Ki 27Inhibition of [3H]5'-(N-ethylcarbamoyl)-adenosine binding to Adenosine A2 receptor in rat striatal membranes in the presence of 50 nM cyclopentyladenosine [AID33565, Type: Literature]Adenosine receptor A2b [gi:112939]
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40
[SID103178995]
Ki 27Inhibition of [3H]5'-(N-ethylcarbamoyl)-adenosine binding to Adenosine A2 receptor in rat striatal membranes in the presence of 50 nM cyclopentyladenosine [AID33565, Type: Literature]Adenosine receptor A2a [gi:8928539]
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41
[SID103178995]
Ki 29Binding affinity to adenosine A1 receptor [AID379301, Type: Literature]
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42
[SID103178995]
Ki 29Binding affinity against Adenosine A1 receptor in rat brain membrane, using [3H]N6-cyclohexyladenosine as the radioligand [AID31861, Type: Literature]
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43
[SID103178995]
Ki 29Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]PIA as radioligand [AID31887, Type: Literature]
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44
[SID103178995]
Ki 29Affinity to A1 adenosine receptor was measured by the displacement of [3H]PIA in bovine brain cortical membrane [AID31980, Type: Literature]
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45
[SID103178995]
Ki 29Displacement of [3H]PIA from adenosine A1 receptors of rat brain membrane [AID32514, Type: Literature]
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46
[SID103178995]
Ki 29Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand [AID32177, Type: Literature]
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47
[SID103178995]
Ki 29.1Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand [AID32508, Type: Literature]
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48
[SID103178995]
Ki 29.1Inhibition of N6-[3H]cyclohexyladenosine binding to adenosine A1 receptor from whole brain membranes [AID32494, Type: Literature]Adenosine receptor A1 [gi:2827766]
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49
[SID103178995]
Ki 29.1Binding affinity against adenosine A1 receptor using N6-[3H]-cyclohexyladenosinene in rat whole brain membranes [AID31875, Type: Literature]Adenosine receptor A1 [gi:2827766]
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50
[SID103178995]
Ki 30Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. [AID30797, Type: Literature]
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