Bookmark and Share
Caffeine (CID 2519) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(144)
 
 
Inactive(1415)
 
 
Inconclusive(97)
 
 
Unspecified(1656)
 
 
Top Targets:
7tm 4(164)
 
 
 
 
 
p450(27)
 
 
 
 
 
NR LBD PPAR(26)
 
 
 
NR LBD TR(26)
 
 
 
NR LBD ER(21)
 
 
 
 
BioAssay Types:
Confirmatory(975)
 
 
 
 
 
Literature(528)
 
 
 
 
 
Screening(432)
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(760)
 
 
 
 
 
IC50(192)
 
 
 
 
Ki(125)
 
 
 
EC50(7)
 
 
 
Kd(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2747    Data Row: 3312   Total Pages: 166   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178995]
Ki 2.48Competitive binding affinity to human adenosine A2A receptor expressed in HEK293 cells after 60 mins by fluorescence polarization assay in presence of MRS5346 [AID763043, Type: Literature]Adenosine receptor A2a [gi:543740]
View
2
[SID103178995]
IC50 4.89779Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
3
[SID103178995]
Ki 5.01187Displacement of [3H]ZM241385 from stabilized human adenosine receptor A2a expressed in HEK293 cells followed by receptor capturing on Biocore chips by SPR method [AID607198, Type: Literature]Adenosine receptor A2a [gi:543740]
View
4
[SID103178995]
IC50 7.25Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method [AID759422, Type: Literature]Acetylcholinesterase [gi:113037]
View
5
[SID144208883]
Ratio Potency (uM) 8.09465qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
View
6
[SID103178995]
Ki 9.4Displacement of [3H]CGS21680 from adenosine A2A receptor in rat brain striatal membrane [AID400072, Type: Literature]Adenosine receptor A2a [gi:8928539]
View
7
[SID103178995]
Ki 9.56Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting analysis [AID763042, Type: Literature]Adenosine receptor A2a [gi:543740]
View
8
[SID103178995]
Ki 10.2Inhibition of GDA by colorimetric assay [AID502390, Type: Literature]
View
9
[SID103178995]
Ki 10.4Antagonist activity against human adenosine A2B receptor [AID494495, Type: Literature]Adenosine receptor A2b [gi:112938]
View
10
[SID103178995]
Ki 10.4Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells [AID372174, Type: Literature]Adenosine receptor A2b [gi:112938]
View
11
[SID103178995]
Ki 10.4Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand [AID33176, Type: Literature]
View
12
[SID103178995]
Ki 13.3Binding affinity against human recombinant Adenosine A3 receptor stably expressed in HEK293 cells by displacing [125I]AB-MECA radioligand [AID34580, Type: Literature]
View
13
[SID103178995]
Ki 13.3Displacement of [3H]PSB-11 from human adenosine A3 receptor expressed in CHO cells [AID1057049, Type: Literature]Adenosine receptor A3 [gi:1351831]
View
14
[SID103178995]
Ki 13.3Binding affinity to human adenosine A3 receptor [AID1057059, Type: Literature]Adenosine receptor A3 [gi:1351831]
View
15
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A3 [gi:2506479]
View
16
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A1 [gi:2827766]
View
17
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A2a [gi:8928539]
View
18
[SID103178995]
Ki 15Antagonist binding of 2-chloro-[3H]-adenosine to rat brain [AID195542, Type: Literature]Adenosine receptor A2b [gi:112939]
View
19
[SID103178995]
Ki 16Ability to inhibit binding of [3H]NECA to Adenosine A2A receptor in rat brain striatal membranes [AID35014, Type: Literature]
View
20
[SID103178995]
Ki 17Displacement of [3H]CHA from adenosine A1 receptor in rat brain cortical membrane [AID400069, Type: Literature]Adenosine receptor A1 [gi:2827766]
View