CHEMBL454923 (CID 25185400) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Unspecified(3)
 
 
Top Targets:
RhoGAP Bcr(2)
 
 
PTKc Abl(1)
 
 
PTKc Src like(1)
 
 
BioAssay Types:
Literature(8)
 
 
 
BioActivity Types:
IC50(2)
 
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 8    Data Row: 8   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103591250]
Ki 0.1Inhibition of human recombinant Abl by filter-binding assay [AID370599, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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2
[SID103591250]
Ki 0.1Inhibition of human recombinant Abl by filter-binding assay [AID370599, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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3
[SID103591250]
Ki 0.51Inhibition of human recombinant c-Src by filter-binding assay [AID370598, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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4
[SID103591250]
Ki 0.51Inhibition of human recombinant c-Src by filter-binding assay [AID370598, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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5
[SID103591250]
IC50 27.3Antiproliferative activity against human K562 cells expressing Bcr-Abl after 3 days by MTT assay [AID370600, Type: Literature]
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6
[SID103591250]
 Inhibition of Bcr-Abl phosphorylation in human K562 cells [AID370605, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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7
[SID103591250]
 Inhibition of Bcr-Abl phosphorylation in human KU812 cells [AID370606, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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8
[SID103591250]
IC50 67.1Antiproliferative activity against human KU812 cells expressing Bcr-Abl after 3 days by MTT assay [AID370601, Type: Literature]
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9
[SID103591250]
 Induction of apoptosis in human K562 cells assessed as cleaved/uncleaved PARP ratio at 50 uM after 72 hrs by immunoblot analysis [AID370603, Type: Literature]
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10
[SID103591250]
 Induction of apoptosis in human KU812 cells assessed as cleaved/uncleaved PARP ratio at 50 uM after 72 hrs by immunoblot analysis [AID370604, Type: Literature]
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