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GSK 1838705A (CID 25182616) - Compound BioActivity Data
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BioActivity Outcomes:
Active(85)
 
 
Inactive(4)
 
 
Unspecified(368)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(453)
 
 
 
Confirmatory(4)
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(7)
 
 
Potency(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 457    Data Row: 457   Total Pages: 23   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103629211]
Kd 0.00055Binding constant for ALK kinase domain [AID624944, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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2
[SID103629211]
Kd 0.0011Binding constant for LTK kinase domain [AID624743, Type: Literature]Leukocyte tyrosine kinase receptor [gi:143811416]
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3
[SID103629211]
Kd 0.0017Binding constant for INSR kinase domain [AID624784, Type: Literature]Insulin receptor [gi:308153655]
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4
[SID103629211]
IC50 0.0018Inhibition of IR [AID392240, Type: Literature]
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5
[SID103629211]
IC50 0.002Inhibition of IGF-1R [AID392241, Type: Literature]
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6
[SID103629211]
Kd 0.007Binding constant for IGF1R kinase domain [AID624800, Type: Literature]Insulin-like growth factor 1 receptor [gi:124240]
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7
[SID103629211]
Kd 0.0086Binding constant for INSRR kinase domain [AID625075, Type: Literature]Insulin receptor-related protein [gi:12644000]
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8
[SID103629211]
Kd 0.0093Binding constant for FER kinase domain [AID625010, Type: Literature]Tyrosine-protein kinase Fer [gi:97536202]
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9
[SID103629211]
Kd 0.011Binding constant for MYLK kinase domain [AID624709, Type: Literature]Myosin light chain kinase, smooth muscle [gi:300669714]
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10
[SID103629211]
Kd 0.015Binding constant for ROS1 kinase domain [AID624899, Type: Literature]Proto-oncogene tyrosine-protein kinase ROS [gi:126302596]
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11
[SID103629211]
Kd 0.016Binding constant for CLK2 kinase domain [AID624932, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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12
[SID103629211]
Kd 0.021Binding constant for CLK1 kinase domain [AID624764, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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13
[SID103629211]
Kd 0.047Binding constant for PLK1 kinase domain [AID624975, Type: Literature]Serine/threonine-protein kinase PLK1 [gi:1709658]
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14
[SID103629211]
Kd 0.052Binding constant for FES kinase domain [AID624852, Type: Literature]Tyrosine-protein kinase Fes/Fps [gi:115502390]
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15
[SID103629211]
Kd 0.06Binding constant for CLK4 kinase domain [AID625125, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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16
[SID103629211]
Kd 0.07Binding constant for STK33 kinase domain [AID625138, Type: Literature]Serine/threonine-protein kinase 33 [gi:74761329]
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17
[SID103629211]
Kd 0.074Binding constant for EGFR(T790M) kinase domain [AID625007, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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18
[SID103629211]
Kd 0.076Binding constant for PYK2 kinase domain [AID624732, Type: Literature]Protein-tyrosine kinase 2-beta [gi:3183003]
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19
[SID103629211]
Kd 0.076Binding constant for TTK kinase domain [AID624910, Type: Literature]Dual specificity protein kinase TTK [gi:160112977]
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20
[SID103629211]
IC50 0.079Inhibition of phospho IR by cellular assay [AID392256, Type: Literature]
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