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GSK 1838705A (CID 25182616) - Compound BioActivity Data
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BioActivity Outcomes:
Active(85)
 
 
Inactive(4)
 
 
Unspecified(368)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(453)
 
 
 
Confirmatory(4)
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(7)
 
 
Potency(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 457    Data Row: 457   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103629211]
Kd 0.00055Binding constant for ALK kinase domain [AID624944, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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2
[SID103629211]
Kd 0.0011Binding constant for LTK kinase domain [AID624743, Type: Literature]Leukocyte tyrosine kinase receptor [gi:143811416]
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3
[SID103629211]
Kd 0.0017Binding constant for INSR kinase domain [AID624784, Type: Literature]Insulin receptor [gi:308153655]
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4
[SID103629211]
IC50 0.0018Inhibition of IR [AID392240, Type: Literature]
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5
[SID103629211]
IC50 0.002Inhibition of IGF-1R [AID392241, Type: Literature]
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6
[SID103629211]
Kd 0.007Binding constant for IGF1R kinase domain [AID624800, Type: Literature]Insulin-like growth factor 1 receptor [gi:124240]
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7
[SID103629211]
Kd 0.0086Binding constant for INSRR kinase domain [AID625075, Type: Literature]Insulin receptor-related protein [gi:12644000]
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8
[SID103629211]
Kd 0.0093Binding constant for FER kinase domain [AID625010, Type: Literature]Tyrosine-protein kinase Fer [gi:97536202]
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9
[SID103629211]
Kd 0.011Binding constant for MYLK kinase domain [AID624709, Type: Literature]Myosin light chain kinase, smooth muscle [gi:300669714]
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10
[SID103629211]
Kd 0.015Binding constant for ROS1 kinase domain [AID624899, Type: Literature]Proto-oncogene tyrosine-protein kinase ROS [gi:126302596]
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11
[SID103629211]
Kd 0.016Binding constant for CLK2 kinase domain [AID624932, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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12
[SID103629211]
Kd 0.021Binding constant for CLK1 kinase domain [AID624764, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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13
[SID103629211]
Kd 0.047Binding constant for PLK1 kinase domain [AID624975, Type: Literature]Serine/threonine-protein kinase PLK1 [gi:1709658]
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14
[SID103629211]
Kd 0.052Binding constant for FES kinase domain [AID624852, Type: Literature]Tyrosine-protein kinase Fes/Fps [gi:115502390]
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15
[SID103629211]
Kd 0.06Binding constant for CLK4 kinase domain [AID625125, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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16
[SID103629211]
Kd 0.07Binding constant for STK33 kinase domain [AID625138, Type: Literature]Serine/threonine-protein kinase 33 [gi:74761329]
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17
[SID103629211]
Kd 0.074Binding constant for EGFR(T790M) kinase domain [AID625007, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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18
[SID103629211]
Kd 0.076Binding constant for PYK2 kinase domain [AID624732, Type: Literature]Protein-tyrosine kinase 2-beta [gi:3183003]
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19
[SID103629211]
Kd 0.076Binding constant for TTK kinase domain [AID624910, Type: Literature]Dual specificity protein kinase TTK [gi:160112977]
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20
[SID103629211]
IC50 0.079Inhibition of phospho IR by cellular assay [AID392256, Type: Literature]
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21
[SID103629211]
IC50 0.085Inhibition of phospho IGFR1 by cellular assay [AID392244, Type: Literature]
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22
[SID103629211]
Kd 0.13Binding constant for JNK3 kinase domain [AID624891, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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23
[SID103629211]
Kd 0.15Binding constant for EGFR(L858R,T790M) kinase domain [AID625004, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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24
[SID103629211]
Kd 0.17Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain [AID624960, Type: Literature]Ribosomal protein S6 kinase alpha-3 [gi:1730070]
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25
[SID103629211]
Kd 0.17Binding constant for LRRK2(G2019S) kinase domain [AID624741, Type: Literature]Leucine-rich repeat serine/threonine-protein kinase 2 [gi:294862450]
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26
[SID103629211]
Kd 0.19Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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27
[SID103629211]
Kd 0.2Binding constant for FAK kinase domain [AID624729, Type: Literature]Focal adhesion kinase 1 [gi:3183518]
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28
[SID103629211]
Kd 0.21Binding constant for JNK1 kinase domain [AID624889, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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29
[SID103629211]
Kd 0.27Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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30
[SID103629211]
Kd 0.28Binding constant for CHEK2 kinase domain [AID624803, Type: Literature]Serine/threonine-protein kinase Chk2 [gi:6685284]
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31
[SID103629211]
Kd 0.3Binding constant for AXL kinase domain [AID624840, Type: Literature]Tyrosine-protein kinase receptor UFO [gi:239938818]
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32
[SID103629211]
IC50 0.31Inhibition of phospho IGFR1 by cellular assay in presence of 2%HSA [AID392257, Type: Literature]
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33
[SID103629211]
Kd 0.41Binding constant for PRKD3 kinase domain [AID625024, Type: Literature]Serine/threonine-protein kinase D3 [gi:12230239]
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34
[SID103629211]
Kd 0.41Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain [AID624900, Type: Literature]Ribosomal protein S6 kinase alpha-1 [gi:20178306]
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35
[SID103629211]
Kd 0.47Binding constant for CAMK4 kinase domain [AID624843, Type: Literature]Calcium/calmodulin-dependent protein kinase type IV [gi:2499586]
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36
[SID103629211]
Kd 0.47Binding constant for TSSK1B kinase domain [AID625142, Type: Literature]Testis-specific serine/threonine-protein kinase 1 [gi:30316282]
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37
[SID103629211]
Kd 0.52Binding constant for JNK2 kinase domain [AID624717, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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38
[SID103629211]
Kd 0.54Binding constant for GRK7 kinase domain [AID624719, Type: Literature]G protein-coupled receptor kinase 7 [gi:21263659]
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39
[SID103629211]
Kd 0.62Binding constant for DAPK1 kinase domain [AID624971, Type: Literature]Death-associated protein kinase 1 [gi:317373595]
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40
[SID103629211]
Kd 0.65Binding constant for PRKD1 kinase domain [AID624884, Type: Literature]Serine/threonine-protein kinase D1 [gi:209572639]
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41
[SID103629211]
Kd 0.73Binding constant for LRRK2 kinase domain [AID624740, Type: Literature]Leucine-rich repeat serine/threonine-protein kinase 2 [gi:294862450]
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42
[SID103629211]
Kd 0.78Binding constant for CSNK1E kinase domain [AID624847, Type: Literature]Casein kinase I isoform epsilon [gi:1346369]
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43
[SID103629211]
Kd 0.83Binding constant for GRK1 kinase domain [AID624898, Type: Literature]Rhodopsin kinase [gi:2833269]
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44
[SID103629211]
Kd 0.91Binding constant for MEK4 kinase domain [AID624902, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 4 [gi:1170596]
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45
[SID103629211]
Kd 0.97Binding constant for DYRK1B kinase domain [AID624964, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1B [gi:9296963]
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46
[SID103629211]
Kd 1Binding constant for MEK3 kinase domain [AID624894, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 3 [gi:24638466]
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47
[SID103629211]
Kd 1.1Binding constant for PHKG1 kinase domain [AID625035, Type: Literature]Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [gi:2833281]
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48
[SID103629211]
Kd 1.1Binding constant for DAPK2 kinase domain [AID625077, Type: Literature]Death-associated protein kinase 2 [gi:38605084]
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49
[SID103629211]
Kd 1.2Binding constant for DAPK3 kinase domain [AID624834, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
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50
[SID103629211]
Kd 1.2Binding constant for HIPK4 kinase domain [AID624720, Type: Literature]Homeodomain-interacting protein kinase 4 [gi:74762559]
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