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SureCN2535768 (CID 25181243) - Compound BioActivity Data
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BioActivity Outcomes:
Active(67)
 
 
Inactive(365)
 
 
Inconclusive(26)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
 
Peptidase C48(8)
 
 
 
alkPPc(5)
 
 
APOBEC C(5)
 
 
 
BioAssay Types:
Screening(320)
 
 
 
 
Confirmatory(127)
 
 
 
 
 
Literature(9)
 
 
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(23)
 
 
 
 
AC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 423    Data Row: 461   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID131281810]
IC50 1Inhibition of human purified phosphomannose isomerase [AID597374, Type: Literature]Mannose-6-phosphate isomerase [gi:462567]
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2
[SID57287680]
IC50_Mean 1.03Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1535, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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3
[SID85147392]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID85147392]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID85147392]
Potency 2.6679qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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6
[SID85147392]
Potency 2.8184qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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7
[SID85147392]
Potency 2.8184qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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8
[SID85147392]
Potency 3.5481qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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9
[SID85147392]
Potency 4.1475Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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10
[SID85147392]
IC50 5.42Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]receptor-interacting serine/threonine-protein kinase 2 [Homo sapiens] [gi:4506537]
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11
[SID85147392]
IC50 5.42Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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12
[SID85147392]
AC50_uM 5.92LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
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13
[SID85147392]
AC50_uM 6Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_Dose_CherryPick_Activity [AID588764, Type: confirmatory]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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14
[SID85147392]
AC50_uM 6Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_Dose_CherryPick_Activity [AID588764, Type: confirmatory]hypothetical protein CaO19.6625 [Candida albicans SC5314] [gi:68488893]
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15
[SID131281810]
IC50 6.5Inhibition of human recombinant MIF tautomerase activity using 4-hydroxyphenylpyruvate as substrate [AID609134, Type: Literature]Macrophage migration inhibitory factor [gi:1170955]
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16
[SID85147392]
AC50_uM 6.6Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
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17
[SID85147392]
Potency 6.7456qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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18
[SID85147392]
Potency 8.9125qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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19
[SID131281810]
IC50 9.1Inhibition of human purified PMM2 [AID597375, Type: Literature]Phosphomannomutase 2 [gi:3024413]
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20
[SID57287680]
IC50_Mean 9.11Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay [AID1655, Type: confirmatory]phosphomannomutase 2 [Homo sapiens] [gi:4557839]
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21
[SID85147392]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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22
[SID85147392]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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23
[SID85147392]
Potency 10qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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24
[SID85147392]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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25
[SID85147392]
IC50_Mean 10.8Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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26
[SID85147392]
Potency 11.2202qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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27
[SID85147392]
Potency 25.1189qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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28
[SID85147392]
IC50 45.21Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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29
[SID85147392]
CC50 100Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
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30
[SID85147392]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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31
[SID85147392]
Counterscreen for IDE inhibitors: Luminescence-based cell-based high throughput assay to identify cytotoxic compounds using HEK cells [AID449730, Type: screening]
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32
[SID85147392]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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33
[SID85147392]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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34
[SID85147392]
Fluorescence polarization-based cell-based high throughput confirmation assay for inhibitors of insulin-degrading enzyme (IDE) [AID435028, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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35
[SID85147392]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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36
[SID85147392]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488912, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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37
[SID85147392]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay [AID488919, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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38
[SID85147392]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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39
[SID85147392]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID488796, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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40
[SID85147392]
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]hepatocyte nuclear factor 4-alpha isoform HNF4alpha2 [Homo sapiens] [gi:31077205]
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41
[SID85147392]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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42
[SID85147392]
Luminescence-based biochemical high throughput confirmation assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651612, Type: screening]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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43
[SID85147392]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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44
[SID85147392]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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45
[SID85147392]
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.6625 [Candida albicans SC5314] [gi:68488893]
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46
[SID85147392]
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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47
[SID85147392]
uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay [AID588489, Type: screening]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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48
[SID85147392]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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49
[SID85147392]
Fluorescence-based cell-based high throughput confirmation assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624370, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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50
[SID85147392]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
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