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AGN-PC-04XEKE (CID 25181243) - Compound BioActivity Data
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BioActivity Outcomes:
Active(67)
 
 
Inactive(373)
 
 
Inconclusive(26)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
 
Peptidase C48(8)
 
 
 
APOBEC C(5)
 
 
 
alkPPc(5)
 
 
BioAssay Types:
Screening(322)
 
 
 
 
Confirmatory(127)
 
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(23)
 
 
 
 
AC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 425    Data Row: 469   Total Pages: 24   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID131281810]
IC50 1Inhibition of human purified phosphomannose isomerase [AID597374, Type: Literature]Mannose-6-phosphate isomerase [gi:462567]
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2
[SID57287680]
IC50_Mean 1.03Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1535, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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3
[SID85147392]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID85147392]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID85147392]
Potency 2.6679qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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6
[SID85147392]
Potency 2.8184qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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7
[SID85147392]
Potency 2.8184qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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8
[SID85147392]
Potency 3.5481qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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9
[SID85147392]
Potency 4.1475Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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10
[SID85147392]
IC50 5.42Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]receptor-interacting serine/threonine-protein kinase 2 [Homo sapiens] [gi:4506537]
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11
[SID85147392]
IC50 5.42Fluorescence-based cell-based high throughput dose response assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID651553, Type: confirmatory]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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12
[SID85147392]
AC50_uM 5.92LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
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13
[SID85147392]
AC50_uM 6Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_Dose_CherryPick_Activity [AID588764, Type: confirmatory]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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14
[SID85147392]
AC50_uM 6Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_Dose_CherryPick_Activity [AID588764, Type: confirmatory]hypothetical protein CaO19.6625 [Candida albicans SC5314] [gi:68488893]
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15
[SID131281810]
IC50 6.5Inhibition of human recombinant MIF tautomerase activity using 4-hydroxyphenylpyruvate as substrate [AID609134, Type: Literature]Macrophage migration inhibitory factor [gi:1170955]
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16
[SID85147392]
AC50_uM 6.6Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
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17
[SID85147392]
Potency 6.7456qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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18
[SID85147392]
Potency 8.9125qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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19
[SID131281810]
IC50 9.1Inhibition of human purified PMM2 [AID597375, Type: Literature]Phosphomannomutase 2 [gi:3024413]
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20
[SID57287680]
IC50_Mean 9.11Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay [AID1655, Type: confirmatory]phosphomannomutase 2 [Homo sapiens] [gi:4557839]
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