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AGN-PC-04XEJ9 (CID 25181201) - Compound BioActivity Data
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BioActivity Outcomes:
Active(61)
 
 
Inactive(393)
 
 
Inconclusive(17)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
 
APOBEC C(6)
 
 
 
G6PD N(5)
 
 
alkPPc(5)
 
 
BioAssay Types:
Screening(325)
 
 
 
 
Confirmatory(127)
 
 
 
 
 
Literature(16)
 
 
 
 
BioActivity Types:
Potency(101)
 
 
 
 
 
IC50(24)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 433    Data Row: 475   Total Pages: 24   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85147391]
IC50_Mean 1.24Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504765, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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2
[SID85147391]
Potency 1.4716Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID57287555]
IC50_Mean 1.88Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1535, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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4
[SID131273767]
IC50 1.9Inhibition of human purified phosphomannose isomerase [AID597374, Type: Literature]Mannose-6-phosphate isomerase [gi:462567]
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5
[SID85147391]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID85147391]
Potency 2.1192qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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7
[SID85147391]
Potency 3.0131qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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8
[SID85147391]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID85147391]
Potency 3.5481qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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10
[SID85147391]
EC50_MICROM 3.624HTS for developing T Cell Immune Modulators: Dose-Response Assay [AID485284, Type: confirmatory]
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11
[SID85147391]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID85147391]
Potency 10qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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13
[SID85147391]
IC50_Mean 10.5Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase [AID540252, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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14
[SID85147391]
IC50_Mean 11.3Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase [AID504792, Type: confirmatory]glucose-6-phosphate 1-dehydrogenase isoform b [Homo sapiens] [gi:108773793]
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15
[SID85147391]
IC50_Mean 11.4Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase [AID540269, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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16
[SID85147391]
IC50_Mean 13.5Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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17
[SID85147391]
Potency 14.1254qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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18
[SID85147391]
Potency 16.9441Inhibitors of T. brucei phosphofructokinase: Hit Validation [AID504637, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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19
[SID85147391]
Potency 17.7828qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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20
[SID85147391]
Potency 18.3564A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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