SureCN12230502 (CID 25181201) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(55)
 
 
Inactive(316)
 
 
Inconclusive(15)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(6)
 
 
 
APOBEC C(6)
 
 
 
6PGL(5)
 
 
alkPPc(5)
 
 
BioAssay Types:
Screening(269)
 
 
 
 
Confirmatory(105)
 
 
 
 
 
Literature(10)
 
 
 
 
BioActivity Types:
Potency(82)
 
 
 
 
 
IC50(21)
 
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 390    Data Row: 390   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85147391]
IC50 1.24Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504765, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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2
[SID85147391]
Potency 1.4716Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID57287555]
IC50 1.88Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1535, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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4
[SID57287555]
IC50 1.88Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1535, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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5
[SID131273767]
IC50 1.9Inhibition of human purified phosphomannose isomerase [AID597374, Type: Literature]Mannose-6-phosphate isomerase [gi:462567]
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6
[SID131273767]
IC50 1.9Inhibition of human purified phosphomannose isomerase [AID597374, Type: Literature]Mannose-6-phosphate isomerase [gi:462567]
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7
[SID85147391]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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8
[SID85147391]
Potency 3.0131qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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9
[SID85147391]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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10
[SID85147391]
Potency 3.5481qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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11
[SID85147391]
Potency 3.5481qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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12
[SID85147391]
EC50 3.624HTS for developing T Cell Immune Modulators: Dose-Response Assay [AID485284, Type: confirmatory]
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13
[SID85147391]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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14
[SID85147391]
Potency 10qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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15
[SID85147391]
Potency 10qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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16
[SID85147391]
IC50 10.5Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase [AID540252, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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17
[SID85147391]
IC50 11.3Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase [AID504792, Type: confirmatory]G6PD gene product [Homo sapiens] [gi:108773793]
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18
[SID85147391]
IC50 11.3Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase [AID504792, Type: confirmatory]G6PD gene product [Homo sapiens] [gi:108773793]
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19
[SID85147391]
IC50 11.4Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase [AID540269, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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20
[SID85147391]
IC50 13.5Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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21
[SID85147391]
Potency 14.1254qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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22
[SID85147391]
Potency 16.9441Inhibitors of T. brucei phosphofructokinase: Hit Validation [AID504637, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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23
[SID85147391]
Potency 17.7828qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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24
[SID85147391]
Potency 18.3564A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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25
[SID85147391]
Potency 19.0115Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation [AID504636, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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26
[SID85147391]
Potency 19.9526Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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27
[SID85147391]
Potency 19.9526Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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28
[SID85147391]
Potency 19.9526Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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29
[SID85147391]
Potency 19.9526Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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30
[SID85147391]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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31
[SID57287555]
IC50 31.3Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay [AID1655, Type: confirmatory]phosphomannomutase 2 [Homo sapiens] [gi:4557839]
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32
[SID57287555]
IC50 31.3Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay [AID1655, Type: confirmatory]phosphomannomutase 2 [Homo sapiens] [gi:4557839]
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33
[SID131273767]
IC50 31.3Inhibition of human purified PMM2 [AID597375, Type: Literature]Phosphomannomutase 2 [gi:3024413]
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34
[SID131273767]
IC50 31.3Inhibition of human purified PMM2 [AID597375, Type: Literature]Phosphomannomutase 2 [gi:3024413]
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35
[SID85147391]
IC50 34.04Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]RACGAP1 gene product [Homo sapiens] [gi:21361397]
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36
[SID85147391]
CC50 67.524Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
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37
[SID85147391]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]
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38
[SID85147391]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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39
[SID85147391]
 Counterscreen for inhibitors of TLR9-MyD88 binding: luminescence-based cell-based high throughput assay to identify compounds that are cytotoxic to TLR9-MyD88 CHO cells [AID588336, Type: screening]
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40
[SID85147391]
 HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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41
[SID85147391]
 Counterscreen for IDE inhibitors: Luminescence-based cell-based high throughput assay to identify cytotoxic compounds using HEK cells [AID449730, Type: screening]
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42
[SID85147391]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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43
[SID85147391]
 Single concentration confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504753, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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44
[SID85147391]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]
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45
[SID85147391]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
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46
[SID85147391]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
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47
[SID85147391]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
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48
[SID85147391]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
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49
[SID85147391]
 Fluorescence polarization-based cell-based high throughput confirmation assay for inhibitors of insulin-degrading enzyme (IDE) [AID435028, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
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50
[SID85147391]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624127, Type: screening]CHRM4 gene product [Homo sapiens] [gi:52426748]
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