MLS002460502 (CID 25181200) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(35)
 
 
Inactive(320)
 
 
Inconclusive(20)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(6)
 
 
APOBEC C(6)
 
 
 
alkPPc(5)
 
 
Peptidase M16(4)
 
 
 
BioAssay Types:
Screening(262)
 
 
 
 
Confirmatory(103)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(82)
 
 
 
 
 
IC50(17)
 
 
 
AC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 376    Data Row: 376   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85147395]
Potency 1.2589qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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2
[SID85147395]
Potency 1.2589qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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3
[SID85147395]
IC50 2.381Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE) [AID463220, Type: confirmatory]IDE gene product [Homo sapiens] [gi:155969707]
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4
[SID85147395]
Potency 2.8184qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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5
[SID57287554]
IC50 3.29Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1535, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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6
[SID57287554]
IC50 3.29Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1535, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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7
[SID85147395]
IC50 4.85Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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8
[SID85147395]
Potency 6.012qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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9
[SID85147395]
Potency 7.0795Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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10
[SID85147395]
Potency 7.0795Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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11
[SID85147395]
Potency 7.0795Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID85147395]
Potency 7.0795Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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13
[SID85147395]
Potency 8.9125qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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14
[SID85147395]
Potency 8.9125qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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15
[SID85147395]
AC50 10.47Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_Dose_CherryPick_Activity [AID588764, Type: confirmatory]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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16
[SID85147395]
Potency 15.1014Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation [AID504636, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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17
[SID85147395]
Potency 16.9441Inhibitors of T. brucei phosphofructokinase: Hit Validation [AID504637, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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18
[SID85147395]
Potency 19.9526qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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19
[SID85147395]
IC50 30.08Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]RACGAP1 gene product [Homo sapiens] [gi:21361397]
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20
[SID57287554]
IC50 52.5Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay [AID1655, Type: confirmatory]phosphomannomutase 2 [Homo sapiens] [gi:4557839]
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21
[SID57287554]
IC50 52.5Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay [AID1655, Type: confirmatory]phosphomannomutase 2 [Homo sapiens] [gi:4557839]
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22
[SID57287554]
 Toxicity Screening of PMI Inhibitors in Hela cells [AID1620, Type: other]MPI protein [Homo sapiens] [gi:16878311]
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23
[SID57287554]
 Toxicity Screening of PMI Inhibitors in Hela cells [AID1620, Type: other]MPI protein [Homo sapiens] [gi:16878311]
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24
[SID85147395]
 Fluorescence polarization-based cell-based high throughput confirmation assay for inhibitors of insulin-degrading enzyme (IDE) [AID435028, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
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25
[SID85147395]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
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26
[SID85147395]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
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27
[SID85147395]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
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28
[SID85147395]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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29
[SID85147395]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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30
[SID85147395]
 uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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31
[SID85147395]
 HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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32
[SID85147395]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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33
[SID85147395]
 Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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34
[SID85147395]
 Absorbance-based biochemical primary high throughput screening assay to identify activators of Methionine sulfoxide reductase A (MsrA) [AID602163, Type: screening]MSRA protein [Bos taurus] [gi:73586699]
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35
[SID85147395]
 uHTS Colorimetric assay for identification of inhibitors of Scp-1 [AID493091, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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36
[SID85147395]
 In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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37
[SID85147395]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]PADI4 gene product [Homo sapiens] [gi:216548487]
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38
[SID85147395]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]PADI4 gene product [Homo sapiens] [gi:216548487]
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39
[SID85147395]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID488796, Type: screening]PADI4 gene product [Homo sapiens] [gi:216548487]
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40
[SID85147395]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID488796, Type: screening]PADI4 gene product [Homo sapiens] [gi:216548487]
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41
[SID85147395]
 Luminescence-based biochemical high throughput confirmation assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651612, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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42
[SID85147395]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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43
[SID85147395]
 MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_SinglePoint_HTS_Activity [AID652197, Type: screening]ERAP1 protein [Homo sapiens] [gi:21315078]
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44
[SID85147395]
 MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_SinglePoint_HTS_Activity [AID652197, Type: screening]ERAP1 protein [Homo sapiens] [gi:21315078]
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45
[SID85147395]
 Single concentration confirmation of uHTS for APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493152, Type: screening]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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46
[SID85147395]
 uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493012, Type: screening]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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47
[SID85147395]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
View
48
[SID85147395]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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49
[SID85147395]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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50
[SID85147395]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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