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SMR000875321 (CID 25162930) - Compound BioActivity Data
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BioActivity Outcomes:
Active(122)
 
 
Inactive(463)
 
 
Inconclusive(17)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(39)
 
 
 
Esterase lipa..(8)
 
 
 
ABCC CFTR1(7)
 
 
 
Hexokinase 2(6)
 
 
 
SRC-1(6)
 
 
BioAssay Types:
Screening(472)
 
 
 
 
Confirmatory(105)
 
 
 
 
 
Literature(19)
 
 
 
BioActivity Types:
Potency(79)
 
 
 
 
 
IC50(22)
 
 
 
 
AC50(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 408    Data Row: 603   Total Pages: 31   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57260390]
Potency 0.996Activators of T cell receptors: Hit Validation [AID624298, Type: confirmatory]T cell receptor, partial [Homo sapiens] [gi:553160]
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2
[SID99355593]
AbsAC35_uM 1.74Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Fischer Rat Thyroid (FRT) Cells. Measured in Cell-Based System Using Plate Reader - 7017-02_Other_Dose_CherryPick_Activity [AID743402, Type: confirmatory]
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3
[SID57260390]
IC50 1.889Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay [AID540297, Type: confirmatory]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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4
[SID57260390]
Potency 4.4668qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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5
[SID57260390]
Potency 4.7444qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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6
[SID57260390]
Potency 7.9433qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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7
[SID99355593]
AbsAC35_uM 8.34HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Other_Dose_CherryPick_Activity_Set2 [AID743395, Type: confirmatory]
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8
[SID57260390]
Potency 9.2Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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9
[SID57260390]
Potency 10.3119qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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10
[SID57260390]
IC50_Mean 14.4Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) [AID504729, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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11
[SID57260390]
Potency 15.8489Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID57260390]
Potency 15.8489qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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13
[SID99355593]
AC50_uM 16.67Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_Dose_CherryPick_Activity [AID743267, Type: confirmatory]cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 [Homo sapiens] [gi:89348172]
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14
[SID57260390]
Potency 17.7828qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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15
[SID57260390]
Potency 18.8876qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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16
[SID57260390]
Potency 19.1821qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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17
[SID57260390]
IC50 19.426Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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18
[SID57260390]
Potency 21.5227qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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19
[SID57260390]
Potency 22.3872qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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20
[SID57260390]
Potency 22.3872Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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