MLS002182976 (CID 25162690) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(344)
 
 
Inconclusive(5)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(6)
 
 
Bcl-2 like(4)
 
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(258)
 
 
 
Confirmatory(90)
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(80)
 
 
 
 
IC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 356    Data Row: 356   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57258700]
 Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2177, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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2
[SID57258700]
 Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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3
[SID57258700]
 Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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4
[SID57258700]
 Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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5
[SID57258700]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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6
[SID57258700]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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7
[SID57258700]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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8
[SID57258700]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction. [AID2280, Type: screening]defective in Germ Line Development family member (gld-1) [Caenorhabditis elegans] [gi:17507875]
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9
[SID57258700]
 Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1). [AID2174, Type: screening]acyl-protein thioesterase 1 [Homo sapiens] [gi:5453722]
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10
[SID57258700]
 Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1). [AID2174, Type: screening]acyl-protein thioesterase 1 [Homo sapiens] [gi:5453722]
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11
[SID57258700]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]PADI4 gene product [Homo sapiens] [gi:216548487]
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12
[SID57258700]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]PADI4 gene product [Homo sapiens] [gi:216548487]
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13
[SID57258700]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID57258700]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID57258700]
Potency 0.1636A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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16
[SID57258700]
Potency 2.2387qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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17
[SID57258700]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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18
[SID57258700]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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19
[SID57258700]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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20
[SID57258700]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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21
[SID57258700]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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22
[SID57258700]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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23
[SID57258700]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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24
[SID57258700]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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25
[SID57258700]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]Il2 gene product [Mus musculus] [gi:7110653]
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26
[SID57258700]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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27
[SID57258700]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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28
[SID57258700]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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29
[SID57258700]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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30
[SID57258700]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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31
[SID57258700]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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32
[SID57258700]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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33
[SID57258700]
 HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_Activity [AID488896, Type: screening]Scarb1 gene product [Mus musculus] [gi:14389423]
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34
[SID57258700]
 HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Activator_SinglePoint_HTS_Activity [AID504775, Type: screening]Scarb1 gene product [Mus musculus] [gi:14389423]
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35
[SID57258700]
 uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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36
[SID57258700]
 MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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37
[SID57258700]
 MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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38
[SID57258700]
Potency qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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39
[SID57258700]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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40
[SID57258700]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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41
[SID57258700]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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42
[SID57258700]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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43
[SID57258700]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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44
[SID57258700]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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45
[SID57258700]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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46
[SID57258700]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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47
[SID57258700]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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48
[SID57258700]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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49
[SID57258700]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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50
[SID57258700]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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