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INCB018424 (CID 25126798) - Compound BioActivity Data
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BioActivity Outcomes:
Active(181)
 
 
Inactive(17)
 
 
Inconclusive(1)
 
 
Unspecified(316)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
PTKc Jak2 Jak..(18)
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
 
BioAssay Types:
Literature(496)
 
 
 
 
Confirmatory(18)
 
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(22)
 
 
Potency(20)
 
 
 
Ki(13)
 
 
EC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 513    Data Row: 515   Total Pages: 26   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134449640]
Kd 3.6e-05Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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2
[SID134449640]
Ki 9e-05Inhibition of purified JAK1 incubated for 30 mins [AID706305, Type: Literature]
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3
[SID134449640]
Ki 0.0001Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins [AID696136, Type: Literature]
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4
[SID134449640]
Ki 0.0001Inhibition of human JAK2 (828-1132) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assay [AID750594, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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5
[SID134449640]
Ki 0.0002Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins [AID696135, Type: Literature]
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6
[SID134449640]
Ki 0.0002Inhibition of human JAK1 (837-1142) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assay [AID750595, Type: Literature]Tyrosine-protein kinase JAK1 [gi:215274013]
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7
[SID134449640]
Ki 0.00024Inhibition of purified JAK2 incubated for 30 mins [AID706320, Type: Literature]
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8
[SID134449640]
IC50 0.0003Inhibition of JAK2 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by filtration assay [AID744999, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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9
[SID134449640]
IC50 0.0004Inhibition of TYK2 (unknown origin) [AID1070025, Type: Literature]Non-receptor tyrosine-protein kinase TYK2 [gi:56405328]
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10
[SID134449640]
Ki 0.0005Inhibition of human TYK2 (873-1187) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assay [AID750592, Type: Literature]Non-receptor tyrosine-protein kinase TYK2 [gi:56405328]
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11
[SID134449640]
Ki 0.0005Inhibition of TYK2 (unknown origin) [AID750604, Type: Literature]Non-receptor tyrosine-protein kinase TYK2 [gi:56405328]
View
12
[SID134449640]
Ki 0.0005Inhibition of TYK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins [AID696138, Type: Literature]
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13
[SID134449640]
Ki 0.00055Inhibition of purified TYK2 incubated for 30 mins [AID706303, Type: Literature]
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14
[SID134449640]
IC50 0.0006Inhibition of JAK1 (unknown origin) [AID1070028, Type: Literature]Tyrosine-protein kinase JAK1 [gi:215274013]
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15
[SID134449640]
IC50 0.0007Inhibition of JAK2 (unknown origin) [AID1070027, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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16
[SID134449640]
IC50 0.0008Inhibition of JAK1 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by filtration assay [AID744998, Type: Literature]Tyrosine-protein kinase JAK1 [gi:215274013]
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17
[SID134449640]
Kd 0.0009Binding constant for TYK2(JH1domain-catalytic) kinase domain [AID624912, Type: Literature]Non-receptor tyrosine-protein kinase TYK2 [gi:56405328]
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18
[SID134449640]
IC50 0.00184Inhibition of JAK2 V617F mutant in human SET2 cells assessed as reduction in STAT5 phosphorylation [AID706322, Type: Literature]
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19
[SID134449640]
Kd 0.002Binding constant for JAK3(JH1domain-catalytic) kinase domain [AID624785, Type: Literature]Tyrosine-protein kinase JAK3 [gi:50403745]
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20
[SID134449640]
IC50 0.0028Inhibition of human JAK2 kinase domain expressed in Sf21 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assay [AID690495, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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