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MLS002153484 (CID 25102761) - Compound BioActivity Data
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BioActivity Outcomes:
Active(29)
 
 
Inactive(343)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(33)
 
 
 
APOBEC C(5)
 
 
 
RasGEF(4)
 
 
Esterase lipa..(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(263)
 
 
 
 
Confirmatory(112)
 
 
 
 
 
Literature(13)
 
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(15)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 355    Data Row: 392   Total Pages: 20   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56463765]
Potency 0.7943qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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2
[SID56463765]
Potency 0.9466qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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3
[SID56463765]
Potency 2.3109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID56463765]
Potency 3.5481qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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5
[SID56463765]
Potency 3.5481qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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6
[SID56463765]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID56463765]
Potency 14.1254qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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8
[SID56463765]
Potency 14.581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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9
[SID123096437]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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10
[SID56463765]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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11
[SID56463765]
Potency 23.1093qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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12
[SID56463765]
IC50_Mean 24.4Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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13
[SID56463765]
Potency 25.1189qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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14
[SID56463765]
Potency 50.1187qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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15
[SID56463765]
Potency 70.7946qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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16
[SID56463765]
Potency 79.4328Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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17
[SID56463765]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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18
[SID56463765]
Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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19
[SID56463765]
Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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20
[SID56463765]
Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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