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dynorphin (1-13) (CID 25075996) - Compound BioActivity Data
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BioActivity Outcomes:
Active(30)
 
 
Inactive(60)
 
 
Inconclusive(7)
 
 
Unspecified(6)
 
 
Top Targets:
7tm 4(9)
 
 
 
NR LBD TR(4)
 
 
PLDc mTdp1 2(4)
 
 
HELICc(3)
 
 
Bromo ALL-1(2)
 
 
BioAssay Types:
Confirmatory(58)
 
 
 
Literature(40)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(55)
 
 
 
Ki(16)
 
 
IC50(8)
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 81    Data Row: 103   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103566017]
Ki 8e-07Binding affinity towards Wild-type kappa opioid receptor expressed in HEK cells [AID219259, Type: Literature]
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2
[SID103566017]
IC50 0.000114Inhibition of [3H]U-69593 binding to kappa opioid receptor of guinea pig brain homogenate [AID226073, Type: Literature]Kappa-type opioid receptor [gi:730228]
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3
[SID103566017]
IC50 0.00019Opioid activity in guinea pig ileum [AID79040, Type: Literature]
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4
[SID103566017]
Ki 0.00031Binding affinity to Opioid receptor kappa 1 by competitive inhibition of radioligand [3H]diprenorphine using cloned receptors transiently expressed on CHO cells [AID149137, Type: Literature]Kappa-type opioid receptor [gi:730228]
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5
[SID103566017]
Ki 0.0006Binding constant against E203Q,D204N,D206N EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID65519, Type: Literature]
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6
[SID103566017]
Ki 0.0006Binding affinity towards Mutant E203Q, D204N, D206N, Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141261, Type: Literature]
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7
[SID103566017]
Ki 0.0008Binding constant against wild type EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID148576, Type: Literature]
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8
[SID103566017]
Ki 0.00092Binding affinity to Opioid receptor mu 1 by competitive inhibition of radioligand [3H]DAMGO using cloned receptors transiently expressed on CHO cells [AID147916, Type: Literature]Mu-type opioid receptor [gi:3024265]
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9
[SID103566017]
Ki 0.0011Binding affinity towards mutant E203Q,D204N,D206N,E209Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141263, Type: Literature]
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10
[SID103566017]
Ki 0.0011Binding constant against E203Q,D204N,D206N,E209Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID65522, Type: Literature]
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11
[SID103566017]
IC50 0.00115Inhibition of mu-selective antagonist binding to opioid receptor of guinea pig ileum [AID226076, Type: Literature]Mu-type opioid receptor [gi:3024265]
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12
[SID103566017]
IC50 0.0012Inhibition of mu opioid receptor in guinea pig ileum/longitudinal muscle with myenteric plexus assessed as inhibition of electrically-stimulated muscle contraction [AID749876, Type: Literature]Mu-type opioid receptor [gi:3024265]
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13
[SID103566017]
IC50 0.00129Inhibition of [3H]PL-17 binding to mu opioid receptor of guinea pig brain homogenate [AID226072, Type: Literature]Mu-type opioid receptor [gi:3024265]
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14
[SID103566017]
Ki 0.0034Binding constant against D216N,D217N,E218Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID55440, Type: Literature]
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15
[SID103566017]
Ki 0.0034Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141256, Type: Literature]
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16
[SID103566017]
Ki 0.0036The compound was tested for binding activity towards opioid receptor kappa in guinea pig brain membranes. [AID148103, Type: Literature]Kappa-type opioid receptor [gi:730228]
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17
[SID103566017]
Ki 0.0038Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cell membranes [AID749872, Type: Literature]Delta-type opioid receptor [gi:311033488]
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18
[SID103566017]
Ki 0.004Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cell membranes [AID749873, Type: Literature]Mu-type opioid receptor [gi:464314]
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19
[SID103566017]
IC50 0.00407Inhibition of [3H]DPDPE binding to delta opioid receptor of guinea pig brain homogenate [AID226071, Type: Literature]
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20
[SID103566017]
EC50 0.006Effective concentration to inhibit E203Q,D204N,D206N KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cells [AID65520, Type: Literature]
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