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dynorphin (1-13) (CID 25075996) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(60)
 
 
Inconclusive(7)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srsx(5)
 
 
 
NR LBD TR(4)
 
 
PLDc mTdp1 2(4)
 
 
HELICc(3)
 
 
PLN02808(2)
 
 
BioAssay Types:
Confirmatory(58)
 
 
 
Literature(36)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(55)
 
 
 
Ki(14)
 
 
EC50(6)
 
 
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 77    Data Row: 99   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103566017]
Ki 8e-07Binding affinity towards Wild-type kappa opioid receptor expressed in HEK cells [AID219259, Type: Literature]
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2
[SID103566017]
IC50 0.000114Inhibition of [3H]U-69593 binding to kappa opioid receptor of guinea pig brain homogenate [AID226073, Type: Literature]Kappa-type opioid receptor [gi:730228]
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3
[SID103566017]
IC50 0.00019Opioid activity in guinea pig ileum [AID79040, Type: Literature]
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4
[SID103566017]
Ki 0.00031Binding affinity to Opioid receptor kappa 1 by competitive inhibition of radioligand [3H]diprenorphine using cloned receptors transiently expressed on CHO cells [AID149137, Type: Literature]Kappa-type opioid receptor [gi:730228]
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5
[SID103566017]
Ki 0.0006Binding affinity towards Mutant E203Q, D204N, D206N, Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141261, Type: Literature]
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6
[SID103566017]
Ki 0.0006Binding constant against E203Q,D204N,D206N EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID65519, Type: Literature]
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7
[SID103566017]
Ki 0.0008Binding constant against wild type EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID148576, Type: Literature]
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8
[SID103566017]
Ki 0.00092Binding affinity to Opioid receptor mu 1 by competitive inhibition of radioligand [3H]DAMGO using cloned receptors transiently expressed on CHO cells [AID147916, Type: Literature]Mu-type opioid receptor [gi:3024265]
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9
[SID103566017]
Ki 0.0011Binding affinity towards mutant E203Q,D204N,D206N,E209Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141263, Type: Literature]
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10
[SID103566017]
Ki 0.0011Binding constant against E203Q,D204N,D206N,E209Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID65522, Type: Literature]
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11
[SID103566017]
IC50 0.00115Inhibition of mu-selective antagonist binding to opioid receptor of guinea pig ileum [AID226076, Type: Literature]Mu-type opioid receptor [gi:3024265]
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12
[SID103566017]
IC50 0.00129Inhibition of [3H]PL-17 binding to mu opioid receptor of guinea pig brain homogenate [AID226072, Type: Literature]Mu-type opioid receptor [gi:3024265]
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13
[SID103566017]
Ki 0.0034Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141256, Type: Literature]
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14
[SID103566017]
Ki 0.0034Binding constant against D216N,D217N,E218Q EL-2 Opioid receptor kappa 1 using [3H]diprenorphine as radioligand expressed in HEK cells [AID55440, Type: Literature]
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15
[SID103566017]
Ki 0.0036The compound was tested for binding activity towards opioid receptor kappa in guinea pig brain membranes. [AID148103, Type: Literature]Kappa-type opioid receptor [gi:730228]
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16
[SID103566017]
IC50 0.00407Inhibition of [3H]DPDPE binding to delta opioid receptor of guinea pig brain homogenate [AID226071, Type: Literature]
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17
[SID103566017]
EC50 0.006Effective concentration to inhibit E203Q,D204N,D206N KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cells [AID65520, Type: Literature]
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18
[SID103566017]
EC50 0.006Binding affinity towards Mutant E203Q,D204N,D206N Opioid receptor kappa 1 expressed in HEK cells [AID141259, Type: Literature]
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19
[SID103566017]
EC50 0.008Effective concentration to inhibit D216,ND217N,E218Q KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cells [AID55438, Type: Literature]
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20
[SID103566017]
EC50 0.008Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 expressed in HEK cells [AID141254, Type: Literature]
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21
[SID103566017]
IC50 0.0091Inhibition of delta-selective antagonist binding to opioid receptor of mouse vas dferens [AID226081, Type: Literature]Delta-type opioid receptor [gi:417418]
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22
[SID103566017]
Ki 0.016The compound was tested for binding activity towards Opioid receptor delta 1 in guinea pig brain membranes. [AID150045, Type: Literature]
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23
[SID103566017]
EC50 0.018Effective concentration to inhibit wild type KL-2 Opioid receptor kappa 1 binding to [35S]GTP-gamma-S, expressed in COS cells [AID148443, Type: Literature]
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24
[SID103566017]
EC50 0.018Binding affinity towards k-opioid receptor k-EL-2 mutant (wild-type) expressed in HEK cells [AID148736, Type: Literature]
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25
[SID103566017]
Ki 0.0284Binding affinity to Opioid receptor delta 1 by competitive inhibition of radioligand [3H]DPDPE using cloned receptors transiently expressed on CHO cells [AID149887, Type: Literature]
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26
[SID103566017]
Ki 0.05The compound was tested for binding activity towards opioid receptor mu in guinea pig brain membranes. [AID149021, Type: Literature]Mu-type opioid receptor [gi:3024265]
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27
[SID103566017]
Ki ratio of compound on Opioid receptor kappa 1, Opioid receptor mu 1, Opioid receptor delta 1 opioid receptor; 1/3/92 [AID149563, Type: Literature]Kappa-type opioid receptor [gi:730228]
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28
[SID103566017]
Ratio of potency in the GPI assay (IC50) to Binding affinity (Ki) was determined against Opioid receptor kappa 1 [AID149830, Type: Literature]Kappa-type opioid receptor [gi:730228]
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29
[SID103566017]
Relative affinity for delta and kappa opioid receptors of guinea pig brain homogenate [AID147934, Type: Literature]
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30
[SID103566017]
Selectivity for kappa and mu opioid receptors of guinea pig brain and ileum respectively [AID149847, Type: Literature]
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31
[SID103566017]
Relative affinity for mu and kappa opioid receptors of guinea pig brain homogenate [AID141519, Type: Literature]
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32
[SID103566017]
Ratio of Kcat to Km for ACE2 [AID331173, Type: Literature]
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33
[SID50111489]
Potency 33.5875qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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34
[SID26757060]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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35
[SID26757060]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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36
[SID50111489]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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37
[SID26757060]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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38
[SID26757060]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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39
[SID50111489]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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40
[SID26757060]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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41
[SID50111489]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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42
[SID50111489]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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43
[SID50111489]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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44
[SID50111489]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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45
[SID50111489]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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46
[SID26757060]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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47
[SID26757060]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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48
[SID50111489]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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49
[SID50111489]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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50
[SID50111489]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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