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T6169731 (CID 24983202) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(457)
 
 
Inconclusive(5)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
7TM GPCR Srsx(15)
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
Troponin(4)
 
 
BioAssay Types:
Screening(354)
 
 
 
Confirmatory(114)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(98)
 
 
 
 
IC50(13)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 439    Data Row: 476   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56324959]
IC50 17.984Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor isoform 1 [Homo sapiens] [gi:4501997]
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2
[SID56324959]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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3
[SID56324959]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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4
[SID56324959]
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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5
[SID56324959]
uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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6
[SID56324959]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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7
[SID56324959]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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8
[SID56324959]
Luminescence-based cell-based high throughput confirmation assay for inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504900, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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9
[SID56324959]
Counterscreen for PME1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2232, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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10
[SID56324959]
Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2177, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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11
[SID56324959]
Luminescence-based cell-based high throughput confirmation assay for inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504900, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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12
[SID56324959]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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13
[SID56324959]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID56324959]
Potency qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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15
[SID56324959]
Potency 3.9811qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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16
[SID56324959]
Potency 12.5893qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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17
[SID56324959]
EC50 40HTS Dose response counterscreen for assays utilizing the enzyme, beta-galactosidase - Set 2 [AID485352, Type: confirmatory]LacZ protein [Escherichia coli] [gi:18073591]
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18
[SID56324959]
IC50_Mean 40Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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19
[SID56324959]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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20
[SID56324959]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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21
[SID56324959]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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22
[SID56324959]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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23
[SID56324959]
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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24
[SID56324959]
Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signaling [AID588675, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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25
[SID56324959]
Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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26
[SID56324959]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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27
[SID56324959]
TR-FRET-based primary biochemical high throughput screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). [AID2300, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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28
[SID56324959]
Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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29
[SID56324959]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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30
[SID56324959]
Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_SinglePoint_HTS_Activity [AID488965, Type: screening]protein PvdQ [Pseudomonas aeruginosa LESB58] [gi:218891639]
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31
[SID56324959]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB) [AID504411, Type: screening]sn1-specific diacylglycerol lipase beta isoform 1 [Homo sapiens] [gi:218931251]
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32
[SID56324959]
uHTS Luminescent assay for identification of inhibitors of NALP3 in yeast [AID2825, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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33
[SID56324959]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocysteine [gi:219689243]
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34
[SID56324959]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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35
[SID56324959]
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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36
[SID56324959]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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37
[SID56324959]
Potency Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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38
[SID56324959]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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39
[SID56324959]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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40
[SID56324959]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3) [AID492972, Type: screening]platelet-activating factor acetylhydrolase IB subunit gamma [Homo sapiens] [gi:225543099]
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41
[SID56324959]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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42
[SID56324959]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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43
[SID56324959]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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44
[SID56324959]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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45
[SID56324959]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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46
[SID56324959]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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47
[SID56324959]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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48
[SID56324959]
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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49
[SID56324959]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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50
[SID56324959]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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