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KI-RI (CID 24983198) - Compound BioActivity Data
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BioActivity Outcomes:
Active(53)
 
 
Inactive(245)
 
 
Inconclusive(13)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
 
7TM GPCR Srsx(7)
 
 
 
alkPPc(6)
 
 
 
UBCc(5)
 
 
 
Peptidase M16(4)
 
 
 
BioAssay Types:
Screening(241)
 
 
 
Confirmatory(58)
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(32)
 
 
 
 
IC50(17)
 
 
 
 
EC50(4)
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 282    Data Row: 311   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56436668]
EC50 2.025Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE) [AID588439, Type: confirmatory]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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2
[SID56436668]
IC50 2.071Counterscreen for activators of insulin-degrading enzyme (IDE): fluorescence-based cell-based high throughput dose response LDH release assay to identify compounds that are cytotoxic to HEK cells or compromise cell membrane permeability [AID588440, Type: confirmatory]
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3
[SID56436668]
IC50 2.19Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm [AID493182, Type: confirmatory]ubiquitin-conjugating enzyme E2 N [Homo sapiens] [gi:4507793]
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4
[SID56436668]
Potency 2.2387CHOP2 Reporter Counterscreen Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID493169, Type: confirmatory]enteropeptidase precursor [Homo sapiens] [gi:223942069]
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5
[SID56436668]
EC50 2.324Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay for activators of recombinant IDE [AID588681, Type: confirmatory]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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6
[SID56436668]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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7
[SID56436668]
IC50 3.276Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID493155, Type: confirmatory]ubiquitin-conjugating enzyme E2 N [Homo sapiens] [gi:4507793]
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8
[SID56436668]
AC50_uM 4.659Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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9
[SID56436668]
EC50 5.17A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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10
[SID56436668]
IC50 6.1Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen [AID504689, Type: confirmatory]bcl-2-related protein A1 [Mus musculus] [gi:11024684]
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11
[SID56436668]
Potency 6.5614Confirmation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID493168, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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12
[SID56436668]
AC50_uM 6.724ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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13
[SID56436668]
Potency 12.5893Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a [AID493170, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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14
[SID56436668]
Potency 17.7828qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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15
[SID56436668]
IC50 20.11A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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16
[SID56436668]
IC50 25A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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17
[SID56436668]
Potency 56.2341qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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18
[SID56436668]
IC50 150A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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19
[SID56436668]
uHTS identification of SUMO1-mediated protein-protein interactions [AID602429, Type: screening]SUMO-1 [Homo sapiens] [gi:1762973]
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20
[SID56436668]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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