MLS001070902 (CID 24982644) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(8)
 
 
Inactive(354)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
KCNQ channel(8)
 
 
 
TRP 2(5)
 
 
WD40(4)
 
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(269)
 
 
 
 
Confirmatory(99)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(83)
 
 
 
 
 
IC50(11)
 
 
EC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 378    Data Row: 378   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56323772]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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2
[SID56323772]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID56323772]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID56323772]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID56323772]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID56323772]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID56323772]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID56323772]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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9
[SID56323772]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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10
[SID56323772]
 Confirmatory screen for compounds that inhibit KCNQ2 potassium channels using automated patch clamp [AID588531, Type: other]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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11
[SID56323772]
 Confirmatory screen for compounds that inhibit KCNQ2 potassium channels using automated patch clamp [AID588531, Type: other]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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12
[SID56323772]
 Confirmatory screen for compounds that inhibit KCNQ2 potassium channels [AID493025, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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13
[SID56323772]
 Confirmatory screen for compounds that inhibit KCNQ2 potassium channels [AID493025, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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14
[SID56323772]
 Specificity screen against KCNQ1 for compounds that inhibit KCNQ2 potassium channels [AID493026, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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15
[SID56323772]
 Specificity screen against KCNQ1 for compounds that inhibit KCNQ2 potassium channels [AID493026, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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16
[SID56323772]
 uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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17
[SID56323772]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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18
[SID56323772]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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19
[SID56323772]
Potency 11.2202qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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20
[SID56323772]
EC50 350Fluorescent Cell-Based Secondary Screen to Identify Activators of the Hypoxia Factor Pathway [AID434951, Type: confirmatory]
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21
[SID56323772]
EC50 350Luminescence Cell-Based Confirmation at Dose to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID2089, Type: confirmatory]
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22
[SID56323772]
EC50 350Luminescent Cell-Based Dose Titration Retest Counterscreen to Identify Proteasome Inhibitors [AID2486, Type: confirmatory]
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23
[SID56323772]
 uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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24
[SID56323772]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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25
[SID56323772]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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26
[SID56323772]
 MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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27
[SID56323772]
 MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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28
[SID56323772]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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29
[SID56323772]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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30
[SID56323772]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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31
[SID56323772]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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32
[SID56323772]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Polyadenylation [AID1875, Type: screening]
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33
[SID56323772]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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34
[SID56323772]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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35
[SID56323772]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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36
[SID56323772]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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37
[SID56323772]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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38
[SID56323772]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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39
[SID56323772]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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40
[SID56323772]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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41
[SID56323772]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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42
[SID56323772]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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43
[SID56323772]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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44
[SID56323772]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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45
[SID56323772]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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46
[SID56323772]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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47
[SID56323772]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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48
[SID56323772]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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49
[SID56323772]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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50
[SID56323772]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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