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MLS001101504 (CID 24979611) - Compound BioActivity Data
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BioActivity Outcomes:
Active(39)
 
 
Inactive(424)
 
 
Inconclusive(26)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
ANK(5)
 
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(356)
 
 
 
 
Confirmatory(125)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(101)
 
 
 
 
 
IC50(10)
 
 
 
EC50(8)
 
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 452    Data Row: 490   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56316814]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID56316814]
Potency 0.6513qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID56316814]
Potency 1.0323A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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4
[SID56316814]
Potency 1.632qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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5
[SID56316814]
EC50 2.059Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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6
[SID56316814]
EC50 2.796Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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7
[SID56316814]
AC50_uM 4.158Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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8
[SID56316814]
EC50 4.246Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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9
[SID56316814]
EC50 5.077Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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10
[SID56316814]
EC50 5.241Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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11
[SID56316814]
AC50_uM 5.343ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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12
[SID56316814]
Potency 10qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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13
[SID56316814]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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14
[SID56316814]
Potency 12.5893qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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15
[SID56316814]
Potency 18.3564Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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16
[SID56316814]
AC50_uM 32.97Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
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17
[SID56316814]
Potency 39.8107qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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18
[SID56316814]
EC50_uM 46.75Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) [AID435004, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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19
[SID56316814]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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20
[SID56316814]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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21
[SID56316814]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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22
[SID56316814]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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23
[SID56316814]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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24
[SID56316814]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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25
[SID56316814]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL) [AID2803, Type: screening]Prolyl endopeptidase-like [Homo sapiens] [gi:153217451]
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26
[SID56316814]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL) [AID2751, Type: screening]Prolyl endopeptidase-like [Homo sapiens] [gi:153217451]
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27
[SID56316814]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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28
[SID56316814]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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29
[SID56316814]
MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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30
[SID56316814]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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31
[SID56316814]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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32
[SID56316814]
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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33
[SID56316814]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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34
[SID56316814]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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35
[SID56316814]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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36
[SID56316814]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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37
[SID56316814]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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38
[SID56316814]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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39
[SID56316814]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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40
[SID56316814]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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41
[SID56316814]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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42
[SID56316814]
EC50 120Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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43
[SID56316814]
EC50 150Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression [AID1914, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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44
[SID56316814]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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45
[SID56316814]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity [AID2221, Type: screening]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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46
[SID56316814]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the membrane-associated serine protease Rv3671c in M.tuberculosis [AID2606, Type: screening]Membrane-associated serine protease [Mycobacterium tuberculosis H37Rv] [gi:15610807]
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47
[SID56316814]
Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme - High throughput screening using Fluorescent polarization assay Measured in Biochemical System Using Plate Reader - 2105-01_Inhibitor_SinglePoint_HTS_Activity_Set6 [AID504406, Type: screening]UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) [Mycobacterium tuberculosis H37Rv] [gi:15610945]
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48
[SID56316814]
Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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49
[SID56316814]
uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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50
[SID56316814]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of Histone Deacetylase 3 [AID2718, Type: screening]histone deacetylase 3 [Homo sapiens] [gi:13128862]
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