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T6127743 (CID 24979502) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(464)
 
 
Inconclusive(3)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
MetRS core(5)
 
 
BioAssay Types:
Screening(344)
 
 
 
Confirmatory(121)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(102)
 
 
 
 
IC50(14)
 
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 440    Data Row: 474   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56316656]
IC50 2.719Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID651971, Type: confirmatory]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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2
[SID56316656]
IC50 4.426Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID651989, Type: confirmatory]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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3
[SID56316656]
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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4
[SID56316656]
Luminescence-based biochemical high throughput confirmation assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624412, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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5
[SID56316656]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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6
[SID56316656]
Fluorescent Polarization-based biochemical high throughput orthogonal assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID651607, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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7
[SID56316656]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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8
[SID56316656]
Potency 3.5481qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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9
[SID56316656]
Potency 7.9433qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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10
[SID56316656]
IC50 83.244Counterscreen for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS): Luminescence-based cell-based high throughput dose response assay to identify compounds that are cytotoxic to Jurkat human T lymphocyte cells [AID651972, Type: confirmatory]
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11
[SID56316656]
AC50_uM 420Luminescence Whole-Organism Secondary Assay to Identify Compounds Inducing Growth of Temperature Sensitive Mutant Burl-1 [AID463199, Type: confirmatory]
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12
[SID56316656]
AC50_uM 420Luminescence Whole-Organism Dose Retest to Confirm Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID463204, Type: confirmatory]
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13
[SID56316656]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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14
[SID56316656]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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15
[SID56316656]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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16
[SID56316656]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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17
[SID56316656]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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18
[SID56316656]
AC50_uM SUMO pathway Measured in Whole Organism System Using Plate Reader - 2059-03_Inhibitor_Dose_CherryPick_Activity [AID493004, Type: confirmatory]
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19
[SID56316656]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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20
[SID56316656]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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21
[SID56316656]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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22
[SID56316656]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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23
[SID56316656]
A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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24
[SID56316656]
Potency qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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25
[SID56316656]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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26
[SID56316656]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624126, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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27
[SID56316656]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624127, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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28
[SID56316656]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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29
[SID56316656]
QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). [AID1906, Type: screening]cathepsin L1 [Homo sapiens] [gi:55958172]
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30
[SID56316656]
Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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31
[SID56316656]
MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex-5 [gi:55976631]
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32
[SID56316656]
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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33
[SID56316656]
HTS Assay for Inhibitors of Akt Phophorylation: Primary Screen [AID651550, Type: screening]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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34
[SID56316656]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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35
[SID56316656]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]tyrosine-protein kinase ABL1 isoform a [Homo sapiens] [gi:62362414]
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36
[SID56316656]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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37
[SID56316656]
Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_SinglePoint_HTS_Activity [AID602252, Type: screening]Golgi-associated PDZ and coiled-coil motif-containing protein isoform b [Homo sapiens] [gi:62868213]
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38
[SID56316656]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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39
[SID56316656]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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40
[SID56316656]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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41
[SID56316656]
HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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42
[SID56316656]
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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43
[SID56316656]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID1962, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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44
[SID56316656]
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.6625 [Candida albicans SC5314] [gi:68488893]
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45
[SID56316656]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ras and Rab interactor 1 [Homo sapiens] [gi:68989256]
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46
[SID56316656]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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47
[SID56316656]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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48
[SID56316656]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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49
[SID56316656]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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50
[SID56316656]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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