PP242 (CID 24905147) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(277)
 
 
Inactive(6)
 
 
Inconclusive(1)
 
 
Unspecified(404)
 
 
Top Targets:
PKc(55)
 
 
 
PKc like(34)
 
 
 
STKc AGC(24)
 
 
 
PTKc Abl(16)
 
 
 
PTKc EGFR(12)
 
 
BioAssay Types:
Literature(679)
 
 
 
Confirmatory(7)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(16)
 
 
Potency(7)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 688    Data Row: 688   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123092542]
Kd 0.0021Binding constant for BMPR1B kinase domain [AID624825, Type: Literature]Bone morphogenetic protein receptor type-1B [gi:6226778]
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2
[SID123092542]
Kd 0.0021Binding constant for BMPR1B kinase domain [AID624825, Type: Literature]Bone morphogenetic protein receptor type-1B [gi:6226778]
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3
[SID123092542]
Kd 0.0029Binding constant for ACVRL1 kinase domain [AID624778, Type: Literature]Serine/threonine-protein kinase receptor R3 [gi:3915750]
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4
[SID123092542]
Kd 0.0029Binding constant for ACVRL1 kinase domain [AID624778, Type: Literature]Serine/threonine-protein kinase receptor R3 [gi:3915750]
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5
[SID123092542]
Kd 0.003Binding constant for MTOR kinase domain [AID624972, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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6
[SID123092542]
Kd 0.003Binding constant for MTOR kinase domain [AID624972, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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7
[SID123092542]
Kd 0.004Binding constant for ACVR1 kinase domain [AID624819, Type: Literature]Activin receptor type-1 [gi:462447]
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8
[SID123092542]
Kd 0.004Binding constant for ACVR1 kinase domain [AID624819, Type: Literature]Activin receptor type-1 [gi:462447]
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9
[SID123092542]
Kd 0.004Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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10
[SID123092542]
Kd 0.004Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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11
[SID123092542]
Kd 0.0048Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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12
[SID123092542]
Kd 0.0048Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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13
[SID123092542]
Kd 0.0051Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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14
[SID123092542]
Kd 0.0073Binding constant for MEK5 kinase domain [AID624721, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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15
[SID123092542]
Kd 0.0076Binding constant for ACVR2B kinase domain [AID624820, Type: Literature]Activin receptor type-2B [gi:97535735]
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16
[SID123092542]
Kd 0.0076Binding constant for ACVR2B kinase domain [AID624820, Type: Literature]Activin receptor type-2B [gi:97535735]
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17
[SID123092542]
IC50 0.008Inhibition of mTOR assessed as inhibition of gamma32ATP incorporation to histone H1 by phosphorimaging [AID605437, Type: Literature]
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18
[SID123092542]
IC50 0.008Inhibition of recombinant mTOR by radioactive phosphotransfer assay in presence of 10 uM ATP [AID507076, Type: Literature]
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19
[SID123092542]
Kd 0.009Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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20
[SID123092542]
Kd 0.009Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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21
[SID123092542]
Kd 0.011Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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22
[SID123092542]
Kd 0.011Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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23
[SID123092542]
Kd 0.011Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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24
[SID123092542]
Kd 0.014Binding constant for BRSK1 kinase domain [AID624702, Type: Literature]Serine/threonine-protein kinase BRSK1 [gi:347595639]
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25
[SID123092542]
Kd 0.014Binding constant for BRSK1 kinase domain [AID624702, Type: Literature]Serine/threonine-protein kinase BRSK1 [gi:347595639]
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26
[SID123092542]
Kd 0.018Binding constant for PIP5K1C kinase domain [AID624751, Type: Literature]
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27
[SID123092542]
Kd 0.018Binding constant for ACVR2A kinase domain [AID624838, Type: Literature]Activin receptor type-2A [gi:114722]
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28
[SID123092542]
Kd 0.018Binding constant for ACVR2A kinase domain [AID624838, Type: Literature]Activin receptor type-2A [gi:114722]
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29
[SID123092542]
Kd 0.031Binding constant for CSNK1E kinase domain [AID624847, Type: Literature]Casein kinase I isoform epsilon [gi:1346369]
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30
[SID123092542]
Kd 0.031Binding constant for CSNK1E kinase domain [AID624847, Type: Literature]Casein kinase I isoform epsilon [gi:1346369]
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31
[SID123092542]
Kd 0.031Binding constant for PIK3CD kinase domain [AID624974, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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32
[SID123092542]
Kd 0.031Binding constant for PIK3CD kinase domain [AID624974, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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33
[SID123092542]
Kd 0.041Binding constant for DAPK3 kinase domain [AID624834, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
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34
[SID123092542]
Kd 0.041Binding constant for DAPK3 kinase domain [AID624834, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
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35
[SID123092542]
Kd 0.042Binding constant for PIK3CG kinase domain [AID624879, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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36
[SID123092542]
Kd 0.042Binding constant for PIK3CG kinase domain [AID624879, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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37
[SID123092542]
Kd 0.042Binding constant for BRSK2 kinase domain [AID624929, Type: Literature]Serine/threonine-protein kinase BRSK2 [gi:116241272]
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38
[SID123092542]
Kd 0.042Binding constant for BRSK2 kinase domain [AID624929, Type: Literature]Serine/threonine-protein kinase BRSK2 [gi:116241272]
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39
[SID123092542]
Kd 0.049Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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40
[SID123092542]
Kd 0.049Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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41
[SID123092542]
Kd 0.051Binding constant for MEK1 kinase domain [AID624893, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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42
[SID123092542]
Kd 0.051Binding constant for MEK1 kinase domain [AID624893, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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43
[SID123092542]
Kd 0.056Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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44
[SID123092542]
Kd 0.056Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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45
[SID123092542]
Kd 0.058Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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46
[SID123092542]
Kd 0.058Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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47
[SID123092542]
Kd 0.058Binding constant for ACVR1B kinase domain [AID624943, Type: Literature]Activin receptor type-1B [gi:547775]
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48
[SID123092542]
Kd 0.058Binding constant for ACVR1B kinase domain [AID624943, Type: Literature]Activin receptor type-1B [gi:547775]
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49
[SID123092542]
Kd 0.059Binding constant for DYRK2 kinase domain [AID624918, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase [gi:148887370]
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50
[SID123092542]
Kd 0.06Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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