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PP242 (CID 24905147) - Compound BioActivity Data
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BioActivity Outcomes:
Active(298)
 
 
Inactive(27)
 
 
Inconclusive(43)
 
 
Unspecified(404)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
 
PTKc EGFR(12)
 
 
BioAssay Types:
Literature(680)
 
 
 
Confirmatory(66)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(442)
 
 
 
Potency(84)
 
 
 
 
IC50(16)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 771    Data Row: 772   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123092542]
Kd 0.0021Binding constant for BMPR1B kinase domain [AID624825, Type: Literature]Bone morphogenetic protein receptor type-1B [gi:6226778]
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2
[SID123092542]
Kd 0.0029Binding constant for ACVRL1 kinase domain [AID624778, Type: Literature]Serine/threonine-protein kinase receptor R3 [gi:3915750]
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3
[SID123092542]
Kd 0.003Binding constant for MTOR kinase domain [AID624972, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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4
[SID123092542]
Kd 0.004Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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5
[SID123092542]
Kd 0.004Binding constant for ACVR1 kinase domain [AID624819, Type: Literature]Activin receptor type-1 [gi:462447]
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6
[SID123092542]
Kd 0.0048Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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7
[SID123092542]
Kd 0.0051Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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8
[SID123092542]
Kd 0.0073Binding constant for MEK5 kinase domain [AID624721, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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9
[SID123092542]
Kd 0.0076Binding constant for ACVR2B kinase domain [AID624820, Type: Literature]Activin receptor type-2B [gi:97535735]
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10
[SID123092542]
IC50 0.008Inhibition of recombinant mTOR by radioactive phosphotransfer assay in presence of 10 uM ATP [AID507076, Type: Literature]
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11
[SID123092542]
IC50 0.008Inhibition of mTOR assessed as inhibition of gamma32ATP incorporation to histone H1 by phosphorimaging [AID605437, Type: Literature]
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12
[SID123092542]
Kd 0.009Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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13
[SID123092542]
Kd 0.011Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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14
[SID123092542]
Kd 0.014Binding constant for BRSK1 kinase domain [AID624702, Type: Literature]Serine/threonine-protein kinase BRSK1 [gi:347595639]
View
15
[SID123092542]
Kd 0.018Binding constant for PIP5K1C kinase domain [AID624751, Type: Literature]Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [gi:78099088]
View
16
[SID123092542]
Kd 0.018Binding constant for ACVR2A kinase domain [AID624838, Type: Literature]Activin receptor type-2A [gi:114722]
View
17
[SID123092542]
Kd 0.031Binding constant for CSNK1E kinase domain [AID624847, Type: Literature]Casein kinase I isoform epsilon [gi:1346369]
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18
[SID123092542]
Kd 0.031Binding constant for PIK3CD kinase domain [AID624974, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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19
[SID123092542]
Kd 0.041Binding constant for DAPK3 kinase domain [AID624834, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
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20
[SID123092542]
Kd 0.042Binding constant for PIK3CG kinase domain [AID624879, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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21
[SID123092542]
Kd 0.042Binding constant for BRSK2 kinase domain [AID624929, Type: Literature]Serine/threonine-protein kinase BRSK2 [gi:116241272]
View
22
[SID123092542]
Kd 0.049Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
23
[SID123092542]
Kd 0.051Binding constant for MEK1 kinase domain [AID624893, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
View
24
[SID123092542]
Kd 0.056Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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25
[SID123092542]
Kd 0.058Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
26
[SID123092542]
Kd 0.058Binding constant for ACVR1B kinase domain [AID624943, Type: Literature]Activin receptor type-1B [gi:547775]
View
27
[SID123092542]
Kd 0.059Binding constant for DYRK2 kinase domain [AID624918, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 2 [gi:148887370]
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28
[SID123092542]
Kd 0.06Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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29
[SID123092542]
Kd 0.064Binding constant for BMPR1A kinase domain [AID624945, Type: Literature]Bone morphogenetic protein receptor type-1A [gi:61252444]
View
30
[SID123092542]
Kd 0.065Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain [AID624927, Type: Literature]Ribosomal protein S6 kinase alpha-4 [gi:37999483]
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31
[SID123092542]
Kd 0.069Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
32
[SID123092542]
Kd 0.07Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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33
[SID123092542]
Kd 0.075Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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34
[SID123092542]
Kd 0.077Binding constant for LOK kinase domain [AID625030, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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35
[SID123092542]
Kd 0.077Binding constant for RIPK2 kinase domain [AID624925, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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36
[SID123092542]
Kd 0.078Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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37
[SID123092542]
Kd 0.084Binding constant for SLK kinase domain [AID625086, Type: Literature]STE20-like serine/threonine-protein kinase [gi:74762732]
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38
[SID123092542]
Kd 0.086Binding constant for JAK3(JH1domain-catalytic) kinase domain [AID624785, Type: Literature]Tyrosine-protein kinase JAK3 [gi:50403745]
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39
[SID123092542]
Kd 0.089Binding constant for BMPR2 kinase domain [AID624826, Type: Literature]Bone morphogenetic protein receptor type-2 [gi:12643724]
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40
[SID123092542]
Kd 0.092Binding constant for MEK3 kinase domain [AID624894, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 3 [gi:24638466]
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41
[SID123092542]
Kd 0.094Binding constant for DAPK2 kinase domain [AID625077, Type: Literature]Death-associated protein kinase 2 [gi:38605084]
View
42
[SID144206623]
Potency-Replicate_1 0.0944qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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43
[SID144206623]
Potency 0.0944qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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44
[SID123092542]
Kd 0.097Binding constant for DAPK1 kinase domain [AID624971, Type: Literature]Death-associated protein kinase 1 [gi:317373595]
View
45
[SID123092542]
Kd 0.099Binding constant for EPHA1 kinase domain [AID625008, Type: Literature]Ephrin type-A receptor 1 [gi:317373566]
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46
[SID123092542]
Kd 0.1Binding constant for MAP4K2 kinase domain [AID624959, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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47
[SID123092542]
Kd 0.1Binding constant for TGFBR1 kinase domain [AID624961, Type: Literature]TGF-beta receptor type-1 [gi:547777]
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48
[SID123092542]
IC50 0.1Inhibition of recombinant PI3Kdelta by radioactive phosphotransfer assay in presence of 10 uM ATP [AID507074, Type: Literature]
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49
[SID144206623]
Potency-Replicate_1 0.1059qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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50
[SID123092542]
Kd 0.12Binding constant for ERBB3 kinase domain [AID624851, Type: Literature]Receptor tyrosine-protein kinase erbB-3 [gi:119534]
View