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PP242 (CID 24905147) - Compound BioActivity Data
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BioActivity Outcomes:
Active(296)
 
 
Inactive(32)
 
 
Inconclusive(41)
 
 
Unspecified(404)
 
 
Top Targets:
PTKc Abl(16)
 
 
 
PTKc EGFR(12)
 
 
PI3Kc IA alph..(10)
 
 
PKc like(9)
 
 
 
PTKc Kit(8)
 
 
 
BioAssay Types:
Literature(680)
 
 
 
Confirmatory(67)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(442)
 
 
 
Potency(85)
 
 
 
 
IC50(16)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 772    Data Row: 773   Total Pages: 39   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123092542]
Kd 0.0021Binding constant for BMPR1B kinase domain [AID624825, Type: Literature]Bone morphogenetic protein receptor type-1B [gi:6226778]
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2
[SID123092542]
Kd 0.0029Binding constant for ACVRL1 kinase domain [AID624778, Type: Literature]Serine/threonine-protein kinase receptor R3 [gi:3915750]
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3
[SID123092542]
Kd 0.003Binding constant for MTOR kinase domain [AID624972, Type: Literature]Serine/threonine-protein kinase mTOR [gi:1169735]
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4
[SID123092542]
Kd 0.004Binding constant for ACVR1 kinase domain [AID624819, Type: Literature]Activin receptor type-1 [gi:462447]
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5
[SID123092542]
Kd 0.004Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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6
[SID123092542]
Kd 0.0048Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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7
[SID123092542]
Kd 0.0051Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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8
[SID123092542]
Kd 0.0073Binding constant for MEK5 kinase domain [AID624721, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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9
[SID123092542]
Kd 0.0076Binding constant for ACVR2B kinase domain [AID624820, Type: Literature]Activin receptor type-2B [gi:97535735]
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10
[SID123092542]
IC50 0.008Inhibition of recombinant mTOR by radioactive phosphotransfer assay in presence of 10 uM ATP [AID507076, Type: Literature]
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11
[SID123092542]
IC50 0.008Inhibition of mTOR assessed as inhibition of gamma32ATP incorporation to histone H1 by phosphor imaging [AID605437, Type: Literature]
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12
[SID123092542]
Kd 0.009Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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13
[SID123092542]
Kd 0.011Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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14
[SID123092542]
Kd 0.014Binding constant for BRSK1 kinase domain [AID624702, Type: Literature]Serine/threonine-protein kinase BRSK1 [gi:347595639]
View
15
[SID123092542]
Kd 0.018Binding constant for PIP5K1C kinase domain [AID624751, Type: Literature]Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [gi:78099088]
View
16
[SID123092542]
Kd 0.018Binding constant for ACVR2A kinase domain [AID624838, Type: Literature]Activin receptor type-2A [gi:114722]
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17
[SID123092542]
Kd 0.031Binding constant for CSNK1E kinase domain [AID624847, Type: Literature]Casein kinase I isoform epsilon [gi:1346369]
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18
[SID123092542]
Kd 0.031Binding constant for PIK3CD kinase domain [AID624974, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [gi:67477424]
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19
[SID123092542]
Kd 0.041Binding constant for DAPK3 kinase domain [AID624834, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
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20
[SID123092542]
Kd 0.042Binding constant for PIK3CG kinase domain [AID624879, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
View