MLS001074577 (CID 24892599) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(378)
 
 
Inconclusive(13)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(301)
 
 
 
 
Confirmatory(107)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(80)
 
 
 
 
 
IC50(22)
 
 
 
 
EC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 409    Data Row: 417   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID51090317]
IC50 0.791Dose response counterscreen for EBI2 assay utilizing the enzyme, b-galactosidase [AID652193, Type: confirmatory]Beta-galactosidase [gi:75404427]
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2
[SID51090317]
EC50 1.59Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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3
[SID51090317]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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4
[SID51090317]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID51090317]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID51090317]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID51090317]
CC50 40A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Sensitize Mycobacterium Tuberculosis to Beta-Lactam Antibiotics [AID434958, Type: confirmatory]
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8
[SID51090317]
IC90 100Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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9
[SID51090317]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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10
[SID51090317]
 A CPE Based HTS Assay for Antiviral Drug Screening Against Dengue Virus [AID540333, Type: screening]
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11
[SID51090317]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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12
[SID51090317]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
View
13
[SID51090317]
 uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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14
[SID51090317]
 uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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15
[SID51090317]
 uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]CCR6 gene product [Homo sapiens] [gi:37187860]
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16
[SID51090317]
 uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]CCR6 gene product [Homo sapiens] [gi:37187860]
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17
[SID51090317]
 uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]GPR183 gene product [Homo sapiens] [gi:4826706]
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18
[SID51090317]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651997, Type: screening]GPR183 gene product [Homo sapiens] [gi:4826706]
View
19
[SID51090317]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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20
[SID51090317]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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21
[SID51090317]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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22
[SID51090317]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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23
[SID51090317]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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24
[SID51090317]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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25
[SID51090317]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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26
[SID51090317]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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27
[SID51090317]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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28
[SID51090317]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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29
[SID51090317]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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30
[SID51090317]
 Single concentration validation of small molecule antagonists of the EBI2 receptor via a luminescent beta-galactosidase assay [AID652176, Type: screening]Beta-galactosidase [gi:75404427]
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31
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_1, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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32
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_1, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
View
33
[SID51090317]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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34
[SID51090317]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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35
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_5, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
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36
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_5, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
View
37
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_6, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
View
38
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_6, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
View
39
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_9, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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40
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_9, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
View
41
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_2, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
View
42
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_2, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
View
43
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_3, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
View
44
[SID51090317]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_3, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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45
[SID51090317]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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46
[SID51090317]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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47
[SID51090317]
Potency 0.5012qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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48
[SID51090317]
Potency 15.8489qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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49
[SID51090317]
IC50 20Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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50
[SID51090317]
IC50 20Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
View