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MLS001074577 (CID 24892599) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(445)
 
 
Inconclusive(15)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
 
7TM GPCR Srsx(15)
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(354)
 
 
 
 
Confirmatory(126)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(22)
 
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 444    Data Row: 489   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID51090317]
IC50_b-galactosidase (DX counterscreen)_Mean 0.791Dose response counterscreen for EBI2 assay utilizing the enzyme, b-galactosidase [AID652193, Type: confirmatory]Beta-galactosidase [gi:75404427]
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2
[SID51090317]
EC50 1.59Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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3
[SID51090317]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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4
[SID51090317]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID51090317]
CC50 40A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Sensitize Mycobacterium Tuberculosis to Beta-Lactam Antibiotics [AID434958, Type: confirmatory]
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6
[SID51090317]
IC90 100Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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7
[SID51090317]
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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8
[SID51090317]
A CPE Based HTS Assay for Antiviral Drug Screening Against Dengue Virus [AID540333, Type: screening]
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9
[SID51090317]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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10
[SID51090317]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651997, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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11
[SID51090317]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_1, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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12
[SID51090317]
uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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13
[SID51090317]
Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]5-hydroxytryptamine receptor 5A [Homo sapiens] [gi:13236497]
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14
[SID51090317]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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15
[SID51090317]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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16
[SID51090317]
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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17
[SID51090317]
Single concentration validation of small molecule antagonists of the EBI2 receptor via a luminescent beta-galactosidase assay [AID652176, Type: screening]Beta-galactosidase [gi:75404427]
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18
[SID51090317]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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19
[SID51090317]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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20
[SID51090317]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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21
[SID51090317]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_5, Type: confirmatory]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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22
[SID51090317]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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23
[SID51090317]
Potency qHTS for Inhibitors of KCHN2 3.1: Mutant qHTS [AID720553, Type: confirmatory]potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens] [gi:342840031]
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24
[SID51090317]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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25
[SID51090317]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_6, Type: confirmatory]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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26
[SID51090317]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_9, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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27
[SID51090317]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_2, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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28
[SID51090317]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_3, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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29
[SID51090317]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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30
[SID51090317]
Potency 0.5012qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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31
[SID51090317]
Potency 15.8489qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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32
[SID51090317]
IC50_CXCR6_Mean 20Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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33
[SID51090317]
Potency 44.6684qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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34
[SID51090317]
EC50 60Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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35
[SID51090317]
IC50 (with Meropenem) 100Screen and Counter Screen to Identify Novel Compounds that Selectively Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434987, Type: confirmatory]
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36
[SID51090317]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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37
[SID51090317]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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38
[SID51090317]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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39
[SID51090317]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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40
[SID51090317]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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41
[SID51090317]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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42
[SID51090317]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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43
[SID51090317]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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44
[SID51090317]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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45
[SID51090317]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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46
[SID51090317]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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47
[SID51090317]
uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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48
[SID51090317]
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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49
[SID51090317]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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50
[SID51090317]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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