MLS001065995 (CID 24891800) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(321)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
TRP 2(5)
 
 
7TM GPCR Srsx(4)
 
 
Peptidase C48(4)
 
 
KCNQ channel(4)
 
 
BioAssay Types:
Screening(261)
 
 
 
 
Confirmatory(98)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(80)
 
 
 
 
 
IC50(11)
 
 
AC50(3)
 
 
 
EC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 368    Data Row: 368   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID51085126]
EC50 1.201Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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2
[SID51085126]
AC50 2.342ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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3
[SID51085126]
AC50 2.608Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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4
[SID51085126]
Potency 3.1623qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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5
[SID51085126]
Potency 3.1623qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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6
[SID51085126]
Potency 6.5733Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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7
[SID51085126]
Potency 10.4179Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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8
[SID51085126]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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9
[SID51085126]
Potency 15.8489qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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10
[SID51085126]
Potency 18.3564A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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11
[SID51085126]
Potency 19.9526qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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12
[SID51085126]
Potency 19.9526qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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13
[SID51085126]
Potency 22.3872qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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14
[SID51085126]
Potency 22.3872qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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15
[SID51085126]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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16
[SID51085126]
Potency 35.4813qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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17
[SID51085126]
Potency 44.6684qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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18
[SID51085126]
Potency 44.6684qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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19
[SID51085126]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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20
[SID51085126]
Potency 79.4328qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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21
[SID51085126]
 uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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22
[SID51085126]
 Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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23
[SID51085126]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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24
[SID51085126]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
View
25
[SID51085126]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
View
26
[SID51085126]
 Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]PPP1CA gene product [Homo sapiens] [gi:56790945]
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27
[SID51085126]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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28
[SID51085126]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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29
[SID51085126]
 Single concentration confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based assay [AID624504, Type: screening]
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30
[SID51085126]
 Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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31
[SID51085126]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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32
[SID51085126]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
View
33
[SID51085126]
 uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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34
[SID51085126]
 uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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35
[SID51085126]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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36
[SID51085126]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID51085126]
Potency 19.9526qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
38
[SID51085126]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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39
[SID51085126]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
40
[SID51085126]
Potency 28.1838qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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41
[SID51085126]
EC50 60Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
View
42
[SID51085126]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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43
[SID51085126]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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44
[SID51085126]
Potency 89.1251qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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45
[SID51085126]
Potency 89.1251qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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46
[SID51085126]
AC50 260Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
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47
[SID51085126]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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48
[SID51085126]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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49
[SID51085126]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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50
[SID51085126]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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