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Triazole Ligand, 10c (CID 24881331) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(48)
 
 
Unspecified(6)
 
 
BioAssay Types:
Literature(54)
 
 
 
BioActivity Types:
IC50(28)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 54    Data Row: 54   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103640930]
IC50 0.0072Inhibition of HDAC3 [AID408882, Type: Literature]
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2
[SID103640930]
IC50 0.0072Inhibition of HDAC3 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465151, Type: Literature]
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3
[SID103640930]
IC50 0.0096Inhibition of HDAC6 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465154, Type: Literature]
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4
[SID103640930]
IC50 0.0096Inhibition of HDAC6 [AID408885, Type: Literature]
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5
[SID103640930]
IC50 0.017Antimalarial activity against Plasmodium falciparum D6 by hypoxanthine uptake [AID404448, Type: Literature]
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6
[SID103640930]
IC50 0.017Antimalarial activity against Plasmodium falciparum TM90C2A by hypoxanthine uptake [AID404451, Type: Literature]
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7
[SID103640930]
IC50 0.018Inhibition of HDAC1 [AID408880, Type: Literature]
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8
[SID103640930]
IC50 0.018Inhibition of HDAC1 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465149, Type: Literature]
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9
[SID103640930]
IC50 0.02Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay [AID465157, Type: Literature]
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10
[SID103640930]
IC50 0.02Cytotoxicity against human Mia Paca2 cells after 72 hrs by MTT assay [AID404443, Type: Literature]
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11
[SID103640930]
IC50 0.0277Inhibition of HDAC10 [AID408884, Type: Literature]
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12
[SID103640930]
IC50 0.0277Inhibition of HDAC10 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465153, Type: Literature]
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13
[SID103640930]
IC50 0.032Antimalarial activity against Plasmodium falciparum W2 by hypoxanthine uptake [AID404449, Type: Literature]
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14
[SID103640930]
IC50 0.035Antimalarial activity against Plasmodium falciparum TM91C235 by hypoxanthine uptake [AID404450, Type: Literature]
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15
[SID103640930]
IC50 0.0639Inhibition of HDAC2 [AID408881, Type: Literature]
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16
[SID103640930]
IC50 0.0639Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465150, Type: Literature]
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17
[SID103640930]
IC50 0.2Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay [AID465156, Type: Literature]
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18
[SID103640930]
IC50 0.2Cytotoxicity against human HPDE6c7 cells [AID404447, Type: Literature]
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19
[SID103640930]
IC50 0.2Cytotoxicity against human Hup T3 cells after 72 hrs by MTT assay [AID408889, Type: Literature]
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20
[SID103640930]
IC50 0.4Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay [AID408888, Type: Literature]
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21
[SID103640930]
IC50 0.4Growth inhibition of human BxPC3 cells after 72 hrs by MTS assay [AID465155, Type: Literature]
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22
[SID103640930]
IC50 0.5Cytotoxicity against human Panc 04.03 cells after 72 hrs by MTT assay [AID404444, Type: Literature]
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23
[SID103640930]
IC50 0.8Cytotoxicity against human SU 86.86 cells after 72 hrs by MTT assay [AID404445, Type: Literature]
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24
[SID103640930]
IC50 0.8Growth inhibition of human SU-8686 cells after 72 hrs by MTS assay [AID465159, Type: Literature]
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25
[SID103640930]
IC50 1Cytotoxicity against nontransformed human microvascular epithelial cells [AID404446, Type: Literature]
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26
[SID103640930]
IC50 2.78Inhibition of HDAC8 [AID408883, Type: Literature]
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27
[SID103640930]
IC50 2.78Inhibition of HDAC8 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465152, Type: Literature]
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28
[SID103640930]
Reactivation of p21 expression in human BxPC3 cells at 5 uM after 18 hrs by SDS-PAGE [AID465148, Type: Literature]
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29
[SID103640930]
Reactivation of p15 protein expression in human SU-8686 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465163, Type: Literature]
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30
[SID103640930]
Reactivation of p16 protein expression in human SU-8686 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465164, Type: Literature]
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31
[SID103640930]
Reactivation of p21 protein expression in human SU-8686 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465165, Type: Literature]
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32
[SID103640930]
Reactivation of p27 protein expression in human SU-8686 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465166, Type: Literature]
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33
[SID103640930]
Reactivation of p57 protein expression in human SU-8686 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465167, Type: Literature]
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34
[SID103640930]
Reactivation of p15 protein expression in human SU-8686 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465168, Type: Literature]
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35
[SID103640930]
Reactivation of p16 protein expression in human SU-8686 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465169, Type: Literature]
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36
[SID103640930]
Reactivation of p21 protein expression in human SU-8686 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465170, Type: Literature]
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37
[SID103640930]
Reactivation of p27 protein expression in human SU-8686 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465171, Type: Literature]
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38
[SID103640930]
Reactivation of p57 protein expression in human SU-8686 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465172, Type: Literature]
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39
[SID103640930]
Reactivation of p15 protein expression in human Panc 04.03 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465173, Type: Literature]
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40
[SID103640930]
Reactivation of p16 protein expression in human Panc 04.03 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465174, Type: Literature]
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41
[SID103640930]
Reactivation of p21 protein expression in human Panc 04.03 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465175, Type: Literature]
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42
[SID103640930]
Reactivation of p27 protein expression in human Panc 04.03 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465176, Type: Literature]
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43
[SID103640930]
Reactivation of p57 protein expression in human Panc 04.03 cells xenografted athymic mouse at 10 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465177, Type: Literature]
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44
[SID103640930]
Reactivation of p15 protein expression in human Panc 04.03 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465178, Type: Literature]
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45
[SID103640930]
Reactivation of p16 protein expression in human Panc 04.03 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465179, Type: Literature]
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46
[SID103640930]
Reactivation of p21 protein expression in human Panc 04.03 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465278, Type: Literature]
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47
[SID103640930]
Reactivation of p27 protein expression in human Panc 04.03 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465279, Type: Literature]
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48
[SID103640930]
Reactivation of p57 protein expression in human Panc 04.03 cells xenografted athymic mouse at 100 mg/kg, ip administered every 12 hrs for 48 hrs by SDS-PAGE [AID465280, Type: Literature]
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49
[SID103640930]
IC50 0.5Growth inhibition of human Panc 04.03 cells after 72 hrs by MTS assay [AID465158, Type: Literature]
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50
[SID103640930]
Cell cycle arrest in human Panc 04.03 cells assessed as accumulation at G1 phase at 5 uM after 24 hrs using propidium iodide staining by flow cytometry [AID465160, Type: Literature]
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