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BioActivity Data for Compound CHEMBL1668935 (CID 24871512)

BioActivity Outcomes:
Active(2)
 
 
Unspecified(6)
 
 
Top Targets:
HAD like(2)
 
 
CAP ED(1)
 
 
BioAssay Types:
Literature(4)
 
 
 
BioAssay Categories:
In vitro(3)
 
 
Biochemical(3)
 
 
 
ADME(4)
 
 
BioActivity Types:
IC50(2)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 8    Data Row: 8   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124976565]
IC50 0.0019Inhibition of human soluble epoxide hydrolase [AID568456, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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2
[SID124976565]
IC50 0.0039Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET [AID568458, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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3
[SID124976565]
AUC (24 hrs) in rat at 10 mg/kg, po [AID568460, Type: Literature]
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4
[SID124976565]
Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 [AID1159387, Type: other]
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5
[SID124976565]
% bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. [AID1159389, Type: other]
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6
[SID124976565]
% bound to plasma by equilibrium dialysis. Compound is incubated with whole rat plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. [AID1159390, Type: other]
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7
[SID124976565]
% bound to plasma by equilibrium dialysis. Compound is incubated with whole mouse plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. [AID1159392, Type: other]
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8
[SID124976565]
Inhibition of human ERG by patch clamp analysis [AID568459, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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