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CHEMBL498423 (CID 24868313) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(18)
 
 
Inconclusive(9)
 
 
Unspecified(12)
 
 
Top Targets:
HELICc(3)
 
 
 
MPP CD73 N(3)
 
 
P2X(2)
 
 
Bromo ALL-1(2)
 
 
 
Menin(2)
 
 
 
BioAssay Types:
Confirmatory(25)
 
 
 
 
Literature(19)
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(25)
 
 
 
 
Ki(5)
 
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 49   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103634685]
Ki 0.53Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method [AID461575, Type: Literature]5'-nucleotidase [gi:112826]
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2
[SID103634685]
Ki 1.5Inhibition of rat NTPdase3 by capillary electrophoresis method [AID461583, Type: Literature]Nucleoside triphosphate diphosphohydrolase 3 [gi:81865998]
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3
[SID103634685]
IC50 6.67Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization [AID461585, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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4
[SID103634685]
IC50 10.1Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization [AID461776, Type: Literature]P2Y purinoceptor 4 [gi:1709524]
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5
[SID50112917]
Potency 12.5893qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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6
[SID50112917]
Potency 22.3872qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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7
[SID103634685]
IC50 30Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization [AID461777, Type: Literature]P2Y purinoceptor 6 [gi:2495019]
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8
[SID50112917]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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9
[SID103634685]
Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by competitive Michaelis-Menten plot [AID461577, Type: Literature]5'-nucleotidase [gi:112826]
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10
[SID103634685]
Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by competitive Lineweaver-Burke plot [AID461578, Type: Literature]5'-nucleotidase [gi:112826]
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11
[SID103634685]
IC50 10Antagonist activity against rat P2X2 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current by two-electrode voltage-clamp electrophysiology [AID570116, Type: Literature]P2X purinoceptor 2 [gi:1352688]
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12
[SID103634685]
IC50 10Antagonist activity against rat P2X4 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current by two-electrode voltage-clamp electrophysiology [AID570118, Type: Literature]P2X purinoceptor 4 [gi:1709521]
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13
[SID103634685]
Ki 10Displacement of [3H]PSB0413 from human platelet P2Y12 receptor [AID375433, Type: Literature]P2Y purinoceptor 12 [gi:21263835]
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14
[SID103634685]
Ki 150Inhibition of rat NTPdase1 by capillary electrophoresis method [AID461579, Type: Literature]Ectonucleoside triphosphate diphosphohydrolase 1 [gi:14547936]
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15
[SID103634685]
Ki 400Inhibition of rat NTPdase2 by capillary electrophoresis method [AID461581, Type: Literature]Ectonucleoside triphosphate diphosphohydrolase 2 [gi:18202031]
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16
[SID103634685]
Displacement of [3H]PSB0413 from human platelet P2Y12 receptor at 10 uM [AID375434, Type: Literature]P2Y purinoceptor 12 [gi:21263835]
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17
[SID103634685]
Cytotoxicity against human 1321N1 cells at 0.1 uM after 72 hrs to 144 hrs by MTT assay [AID375432, Type: Literature]
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18
[SID103634685]
Cytotoxicity against human 1321N1 cells at 1 uM after 72 hrs to 144 hrs by MTT assay [AID375445, Type: Literature]
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19
[SID103634685]
Cytotoxicity against human 1321N1 cells at 100 uM after 72 hrs to 144 hrs by MTT assay [AID375446, Type: Literature]
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20
[SID103634685]
Cytotoxicity against human 1539 cells at 0.1 uM after 72 hrs to 144 hrs by MTT assay [AID375447, Type: Literature]
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