CHEMBL498423 (CID 24868313) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(13)
 
 
Inconclusive(8)
 
 
Unspecified(12)
 
 
Top Targets:
HELICc(3)
 
 
 
MPP CD73 N(3)
 
 
RIP(2)
 
 
P2X(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Confirmatory(21)
 
 
 
 
Literature(19)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(21)
 
 
 
 
IC50(5)
 
 
 
Ki(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 43    Data Row: 43   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103634685]
Ki 0.53Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method [AID461575, Type: Literature]5'-nucleotidase [gi:112826]
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2
[SID103634685]
Ki 1.5Inhibition of rat NTPdase3 by capillary electrophoresis method [AID461583, Type: Literature]Nucleoside triphosphate diphosphohydrolase 3 [gi:81865998]
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3
[SID103634685]
IC50 6.67Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization [AID461585, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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4
[SID103634685]
IC50 10.1Antagonist activity at human P2Y4 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization [AID461776, Type: Literature]P2Y purinoceptor 4 [gi:1709524]
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5
[SID50112917]
Potency 12.5893qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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6
[SID50112917]
Potency 12.5893qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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7
[SID50112917]
Potency 22.3872qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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8
[SID103634685]
IC50 30Antagonist activity at rat P2Y6 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization [AID461777, Type: Literature]P2Y purinoceptor 6 [gi:2495019]
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9
[SID50112917]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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10
[SID50112917]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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11
[SID50112917]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID50112917]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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13
[SID103634685]
 Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by competitive Lineweaver-Burke plot [AID461578, Type: Literature]5'-nucleotidase [gi:112826]
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14
[SID103634685]
 Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by competitive Michaelis-Menten plot [AID461577, Type: Literature]5'-nucleotidase [gi:112826]
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15
[SID103634685]
IC50 10Antagonist activity against rat P2X4 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current by two-electrode voltage-clamp electrophysiology [AID570118, Type: Literature]P2X purinoceptor 4 [gi:1709521]
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16
[SID103634685]
IC50 10Antagonist activity against rat P2X2 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current by two-electrode voltage-clamp electrophysiology [AID570116, Type: Literature]P2X purinoceptor 2 [gi:1352688]
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17
[SID103634685]
Ki 10Displacement of [3H]PSB0413 from human platelet P2Y12 receptor [AID375433, Type: Literature]P2Y purinoceptor 12 [gi:21263835]
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18
[SID103634685]
Ki 150Inhibition of rat NTPdase1 by capillary electrophoresis method [AID461579, Type: Literature]Ectonucleoside triphosphate diphosphohydrolase 1 [gi:14547936]
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19
[SID103634685]
Ki 400Inhibition of rat NTPdase2 by capillary electrophoresis method [AID461581, Type: Literature]Ectonucleoside triphosphate diphosphohydrolase 2 [gi:18202031]
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20
[SID103634685]
 Displacement of [3H]PSB0413 from human platelet P2Y12 receptor at 10 uM [AID375434, Type: Literature]P2Y purinoceptor 12 [gi:21263835]
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21
[SID103634685]
 Cytotoxicity against human 1321N1 cells at 1 uM after 72 hrs to 144 hrs by MTT assay [AID375445, Type: Literature]
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22
[SID103634685]
 Cytotoxicity against human 1321N1 cells at 100 uM after 72 hrs to 144 hrs by MTT assay [AID375446, Type: Literature]
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23
[SID103634685]
 Cytotoxicity against human 1539 cells at 0.1 uM after 72 hrs to 144 hrs by MTT assay [AID375447, Type: Literature]
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24
[SID103634685]
 Cytotoxicity against human 1539 cells at 1 uM after 72 hrs to 144 hrs by MTT assay [AID375448, Type: Literature]
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25
[SID103634685]
 Cytotoxicity against human 1539 cells at 100 uM after 72 hrs to 144 hrs by MTT assay [AID375449, Type: Literature]
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26
[SID103634685]
 Cytotoxicity against human 1321N1 cells at 0.1 uM after 72 hrs to 144 hrs by MTT assay [AID375432, Type: Literature]
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27
[SID50112917]
Potency 3.9811qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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28
[SID50112917]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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29
[SID50112917]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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30
[SID50112917]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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31
[SID50112917]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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32
[SID50112917]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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33
[SID50112917]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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34
[SID50112917]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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35
[SID50112917]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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36
[SID50112917]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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37
[SID50112917]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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38
[SID50112917]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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39
[SID50112917]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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40
[SID50112917]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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41
[SID50112917]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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42
[SID50112917]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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43
[SID50112917]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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44
[SID50112917]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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45
[SID50112917]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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46
[SID50112917]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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47
[SID50112917]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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48
[SID50112917]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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49
[SID50112917]
Potency 7.9433qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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50
[SID50112917]
Potency 11.2202VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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