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AGN-PC-04SXNN (CID 24868311) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(18)
 
 
Inconclusive(7)
 
 
Unspecified(6)
 
 
Top Targets:
HELICc(3)
 
 
 
Bromo ALL-1(2)
 
 
 
Menin(2)
 
 
 
NR LBD TR(2)
 
 
 
RIP(2)
 
 
BioAssay Types:
Confirmatory(25)
 
 
 
 
Literature(10)
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(25)
 
 
 
 
Ki(2)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 36    Data Row: 40   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103575465]
Ki 4.81Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method [AID461575, Type: Literature]5'-nucleotidase [gi:112826]
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2
[SID103575465]
IC50 5.31Antagonist activity at human recombinant P2Y2 receptor in 1321N1 cells assessed as inhibition of UTP-induced calcium mobilization [AID315963, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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3
[SID103575465]
Ki 7.35Displacement of [3H]PSB0413 from human platelet P2Y12 receptor [AID375433, Type: Literature]P2Y purinoceptor 12 [gi:21263835]
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4
[SID50112916]
Potency 15.8489qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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5
[SID103575465]
IC50 20Antagonist activity at mouse P2Y2 receptor in mouse NG108-15 cells assessed as inhibition of UTP-induced calcium mobilization [AID315962, Type: Literature]P2Y purinoceptor 2 [gi:548447]
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6
[SID50112916]
Potency 28.1838qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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7
[SID50112916]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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8
[SID50112916]
Potency 31.6228qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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9
[SID50112916]
Potency 50.1187Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks [AID504841, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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10
[SID103575465]
Cytotoxicity against human 1321N1 cells at 1 uM after 72 hrs to 144 hrs by MTT assay [AID375445, Type: Literature]
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11
[SID103575465]
Cytotoxicity against human 1321N1 cells at 100 uM after 72 hrs to 144 hrs by MTT assay [AID375446, Type: Literature]
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12
[SID103575465]
Cytotoxicity against human 1539 cells at 0.1 uM after 72 hrs to 144 hrs by MTT assay [AID375447, Type: Literature]
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13
[SID103575465]
Cytotoxicity against human 1539 cells at 1 uM after 72 hrs to 144 hrs by MTT assay [AID375448, Type: Literature]
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14
[SID103575465]
Cytotoxicity against human 1539 cells at 100 uM after 72 hrs to 144 hrs by MTT assay [AID375449, Type: Literature]
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15
[SID103575465]
Cytotoxicity against human 1321N1 cells at 0.1 uM after 72 hrs to 144 hrs by MTT assay [AID375432, Type: Literature]
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16
[SID50112916]
Potency 10qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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17
[SID50112916]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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18
[SID50112916]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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19
[SID50112916]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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20
[SID50112916]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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