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NCGC00094350-01 (CID 24867533) - Compound BioActivity Data
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BioActivity Outcomes:
Active(20)
 
 
Inactive(34)
 
 
Inconclusive(21)
 
 
Unspecified(1)
 
 
Top Targets:
HELICc(4)
 
 
Bromo ALL-1(3)
 
 
 
ZnF C3H1(3)
 
 
 
 
Git3(2)
 
 
Peptidase C1A(2)
 
 
BioAssay Types:
Confirmatory(72)
 
 
 
 
 
Literature(2)
 
 
Screening(1)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(72)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 72    Data Row: 76   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50106972]
Potency 0.1778qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation in AlphaScreen assay for MBNL1-(CUG)12 binding [AID493205, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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2
[SID50106972]
Potency 3.1623qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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3
[SID50106972]
Potency 4.4668qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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4
[SID50106972]
Potency 5.6234qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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5
[SID50106972]
Potency 8.9125qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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6
[SID50106972]
Potency 10qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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7
[SID50106972]
Potency 12.5893qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2364, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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8
[SID50106972]
Potency 12.5893qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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9
[SID50106972]
Potency 12.5893qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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10
[SID50106972]
Potency 14.1254qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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11
[SID50106972]
Potency 15.8489qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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12
[SID50106972]
Potency 15.8489qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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13
[SID50106972]
Potency 19.9526Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay [AID1707, Type: confirmatory]
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14
[SID50106972]
Potency 22.3872qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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15
[SID50106972]
Potency 25.1189qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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16
[SID50106972]
Potency 25.1189qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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17
[SID50106972]
Potency 25.1189qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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18
[SID50106972]
Potency 25.1189qHTS Validation Assay for Identification of Novel General Anesthetics [AID2323, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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19
[SID50106972]
Potency 28.1838Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV [AID1708, Type: confirmatory]endonuclease IV [Escherichia coli] [gi:405898]
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20
[SID50106972]
Potency 35.4813qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID1705, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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