dihydroouabain (CID 24867490) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(58)
 
 
Inconclusive(9)
 
 
Unspecified(1)
 
 
Top Targets:
HELICc(4)
 
 
 
NR LBD TR(2)
 
 
Menin(2)
 
 
PLN02808(2)
 
 
Geminin(2)
 
 
 
BioAssay Types:
Confirmatory(67)
 
 
 
 
 
Literature(2)
 
 
Screening(1)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(67)
 
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 71    Data Row: 71   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50106118]
Potency 0.3162qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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2
[SID50106118]
Potency 1.5849Validation screen for inhibitors of Lassa infection [AID463096, Type: confirmatory]
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3
[SID50106118]
Potency 1.5849qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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4
[SID50106118]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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5
[SID50106118]
Potency 0.0224qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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6
[SID50106118]
Potency 4.4668qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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7
[SID50106118]
Potency 4.4668qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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8
[SID50106118]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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9
[SID50106118]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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10
[SID50106118]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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11
[SID50106118]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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12
[SID50106118]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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13
[SID50106118]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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14
[SID50106118]
 qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Validation Screen for Agonists [AID493127, Type: screening]thyrotropin-releasing hormone receptor [Homo sapiens] [gi:4507681]
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15
[SID50106118]
Potency Antagonists of the Thyroid Stimulating Hormone Receptor: Validation [AID504821, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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16
[SID50106118]
Potency Antagonists of the Thyroid Stimulating Hormone Receptor: Validation [AID504821, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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17
[SID50106118]
Potency Antagonists of the Thyroid Stimulating Hormone Receptor: Validation [AID504821, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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18
[SID50106118]
Potency qHTS Assay for Antagonists of the Thyroid Stimulating Hormone Receptor [AID488980, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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19
[SID50106118]
Potency qHTS Assay for Antagonists of the Thyroid Stimulating Hormone Receptor [AID488980, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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20
[SID50106118]
Potency qHTS Assay for Antagonists of the Thyroid Stimulating Hormone Receptor [AID488980, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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21
[SID50106118]
Potency HTS Assay for Compounds that Act as Enhancers of the Vanilloid Receptor 1 [AID488979, Type: confirmatory]TRPV1 gene product [Homo sapiens] [gi:74315350]
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22
[SID50106118]
Potency HTS Assay for Compounds that Act as Enhancers of the Vanilloid Receptor 1 [AID488979, Type: confirmatory]TRPV1 gene product [Homo sapiens] [gi:74315350]
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23
[SID50106118]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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24
[SID50106118]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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25
[SID50106118]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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26
[SID50106118]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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27
[SID50106118]
Potency qHTS Validation Assay for Identification of Novel General Anesthetics [AID2323, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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28
[SID50106118]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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29
[SID50106118]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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30
[SID50106118]
Potency qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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31
[SID50106118]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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32
[SID50106118]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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33
[SID50106118]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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34
[SID50106118]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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35
[SID50106118]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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36
[SID50106118]
Potency qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID1705, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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37
[SID50106118]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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38
[SID50106118]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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39
[SID50106118]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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40
[SID50106118]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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41
[SID50106118]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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42
[SID50106118]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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43
[SID123091684]
 Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay [AID521220, Type: Literature]
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44
[SID50106118]
Potency Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV [AID1708, Type: confirmatory]endonuclease IV [Escherichia coli] [gi:405898]
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45
[SID50106118]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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46
[SID50106118]
Potency Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay [AID1707, Type: confirmatory]
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47
[SID50106118]
Potency Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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48
[SID50106118]
Potency Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID488752, Type: confirmatory]
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49
[SID50106118]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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50
[SID50106118]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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