SMR000798332 (CID 24856237) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(14)
 
 
Inactive(403)
 
 
Inconclusive(15)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
ABCC CFTR1(9)
 
 
 
 
7TM GPCR Srsx(6)
 
 
 
Peptidase S9(5)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(288)
 
 
 
 
Confirmatory(139)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(34)
 
 
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 431    Data Row: 443   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50085939]
IC50 2.4Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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2
[SID50085939]
IC50 2.4Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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3
[SID50085939]
IC50 2.4Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
4
[SID50085939]
IC50 3.22Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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5
[SID50085939]
IC50 3.22Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
6
[SID50085939]
IC50 3.22Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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7
[SID50085939]
Potency 6.3096qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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8
[SID50085939]
Potency 6.3096qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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9
[SID50085939]
Potency 20.5962A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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10
[SID50085939]
Potency 28.1838qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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11
[SID50085939]
Potency 28.1838qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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12
[SID50085939]
Potency 28.1838qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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13
[SID50085939]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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14
[SID50085939]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
15
[SID50085939]
 Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
16
[SID50085939]
 Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
17
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_4, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
18
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_4, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
19
[SID50085939]
 Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
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20
[SID50085939]
 Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
View
21
[SID50085939]
 Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
View
22
[SID50085939]
 Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
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23
[SID50085939]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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24
[SID50085939]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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25
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
26
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
27
[SID50085939]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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28
[SID50085939]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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29
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_2, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
30
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_2, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
31
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_3, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
32
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_3, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
33
[SID50085939]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID50085939]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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35
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_5, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
36
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_5, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
37
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_6, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
38
[SID50085939]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_6, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
39
[SID99206501]
 Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: Fluorescence-based biochemical gel-based ABPP inhibition and selectivity [AID463149_1, Type: other]protein phosphatase methylesterase 1 [Homo sapiens] [gi:7706645]
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40
[SID99206501]
 Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: Fluorescence-based biochemical gel-based ABPP inhibition and selectivity [AID463149_6, Type: other]Abhydrolase domain containing 10 [Homo sapiens] [gi:15778873]
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41
[SID99206501]
 Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: Fluorescence-based biochemical gel-based ABPP inhibition and selectivity [AID463149_4, Type: other]N-acylaminoacyl-peptide hydrolase [Homo sapiens] [gi:12804773]
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42
[SID99206501]
 Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: Fluorescence-based biochemical gel-based ABPP inhibition and selectivity [AID463149_5, Type: other]prolyl endopeptidase [Homo sapiens] [gi:119568811]
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43
[SID99206501]
 Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: Fluorescence-based biochemical gel-based ABPP inhibition and selectivity [AID463149_3, Type: other]fatty acid synthase [Homo sapiens] [gi:119610151]
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44
[SID99206501]
 Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: Fluorescence-based biochemical gel-based ABPP inhibition and selectivity [AID463149_2, Type: other]Carboxylesterase 1 (monocyte/macrophage serine esterase 1) [Homo sapiens] [gi:82571745]
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45
[SID50085939]
Potency 3.9811qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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46
[SID50085939]
Potency 4.1475Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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47
[SID50085939]
IC50 4.72Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
48
[SID50085939]
IC50 4.72Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
49
[SID50085939]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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50
[SID50085939]
 uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COPS5 gene product [Homo sapiens] [gi:38027923]
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