MLS001074450 (CID 24820079) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(55)
 
 
Inactive(419)
 
 
Inconclusive(17)
 
 
Unspecified(15)
 
 
Top Targets:
7TM GPCR Srx(13)
 
 
Death TRAILR..(12)
 
 
 
 
PP1c bdg(9)
 
 
 
 
KCNQ channel(8)
 
 
 
7TM GPCR Srsx(6)
 
 
BioAssay Types:
Screening(339)
 
 
 
 
 
Confirmatory(157)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(43)
 
 
 
 
EC50(8)
 
 
 
AC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 487    Data Row: 506   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49829149]
EC50 4.13A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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2
[SID49829149]
CC50 5.991A Cell Based Secondary Assay to Explore Cytotoxicity in HepG2 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489018, Type: confirmatory]
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3
[SID49829149]
CC50 6.707A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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4
[SID49829149]
CC50 6.819A Cell Based Secondary Assay to Explore Cytotoxicity in THP-1 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489025, Type: confirmatory]
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5
[SID49829149]
EC50 7A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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6
[SID49829149]
IC50 7.511Counterscreen for activators of insulin-degrading enzyme (IDE): fluorescence-based cell-based high throughput dose response LDH release assay to identify compounds that are cytotoxic to HEK cells or compromise cell membrane permeability [AID588440, Type: confirmatory]
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7
[SID49829149]
AC50 11.65Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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8
[SID49829149]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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9
[SID49829149]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID49829149]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID49829149]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID49829149]
AC50 14.06Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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13
[SID49829149]
CC50 15.15A Cell Based Secondary Assay to Explore Cytotoxicity in Vero E6 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID492998, Type: confirmatory]
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14
[SID49829149]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID49829149]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID49829149]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
17
[SID49829149]
AC50 16.51Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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18
[SID49829149]
IC50 17.2A Cell Based Secondary Assay to Explore Compounds that Modulate Non-Replicating, Drug-tolerant Compounds in Replicating H37Rv TB of Mycobacterium tuberculosis [AID492952, Type: confirmatory]
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19
[SID49829149]
Potency 25.1189qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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20
[SID49829149]
Potency 31.6228qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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21
[SID49829149]
IC50 37.73A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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22
[SID49829149]
IC50 39.8A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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23
[SID49829149]
IC50 41.96High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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24
[SID49829149]
IC50 45.57A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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25
[SID49829149]
IC50 46.038A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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26
[SID49829149]
IC50 52.11A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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27
[SID49829149]
IC50 53.71A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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28
[SID49829149]
IC50 58.74A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
View
29
[SID49829149]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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30
[SID49829149]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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31
[SID49829149]
 Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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32
[SID49829149]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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33
[SID49829149]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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34
[SID49829149]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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35
[SID49829149]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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36
[SID49829149]
 uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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37
[SID49829149]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
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38
[SID49829149]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2 [AID504601, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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39
[SID49829149]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2 [AID504601, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
40
[SID49829149]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
41
[SID49829149]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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42
[SID49829149]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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43
[SID49829149]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
44
[SID49829149]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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45
[SID49829149]
 Single concentration confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID488859, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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46
[SID49829149]
 Single concentration confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID488859, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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47
[SID49829149]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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48
[SID49829149]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
View
49
[SID49829149]
 Confirmatory screen for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID2032, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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50
[SID49829149]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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