Bookmark and Share
MLS001129129 (CID 24820042) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(19)
 
 
Inactive(501)
 
 
Inconclusive(20)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
ZnMc TACE lik..(6)
 
 
 
RGS RGS4(6)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(380)
 
 
 
Confirmatory(152)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(113)
 
 
 
 
 
IC50(28)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 500    Data Row: 541   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49828715]
AbsAC1000_uM 4.737In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
View
2
[SID49828715]
AbsAC40_uM 5.69In vivo-based yeast HTS counterscreen to detect compounds rescuing yeast growth/survival of Saccharomyces cerevisiae SKN7-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-02_Inhibitor_Dose_CherryPick_Activity [AID624258, Type: confirmatory]Skn7p [Saccharomyces cerevisiae] [gi:458922]
View
3
[SID49828715]
AbsAC35_uM 7.58Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
View
4
[SID49828715]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
5
[SID49828715]
AbsAC35_uM 10.45Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
View
6
[SID49828715]
Potency 12.5893VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
7
[SID49828715]
Potency 19.9526qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
View
8
[SID49828715]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
View
9
[SID49828715]
Validation assay for identification of compounds that inhibit the regulator of G-protein signaling 4 (RGS4) [AID492999, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
View
10
[SID49828715]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
View
11
[SID49828715]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
View
12
[SID49828715]
Counterscreen for molecules that bind rCAG RNA repeats: fluorescent based biochemical counterscreen assay for inhibitors of the DNA-based (5'CAG/3'GTC) TO-PRO-1 dye complex [AID652068, Type: screening]
View
13
[SID49828715]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
View
14
[SID49828715]
Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput screening assay to identify inhibitors of ADAM10 [AID743256, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
View
15
[SID49828715]
In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
View
16
[SID49828715]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro) [AID1706, Type: screening]3C-like protease [Infectious bronchitis virus] [gi:73745819]
View
17
[SID49828715]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
View
18
[SID49828715]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM17 [AID743257, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
View
19
[SID49828715]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase 5 (PP5). [AID1987, Type: screening]PPP5C protein, partial [Homo sapiens] [gi:37589898]
View
20
[SID49828715]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
21
[SID49828715]
Potency 12.5893qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
View
22
[SID49828715]
Potency 17.7828qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
View
23
[SID49828715]
Potency 19.9526qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
View
24
[SID49828715]
Potency 28.1838qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
25
[SID49828715]
Potency 70.7946qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
View
26
[SID49828715]
Potency 100qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
View
27
[SID49828715]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
View
28
[SID49828715]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
View
29
[SID49828715]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
View
30
[SID49828715]
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
View
31
[SID49828715]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
View
32
[SID49828715]
uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
View
33
[SID49828715]
High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) [AID2553, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
View
34
[SID49828715]
High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6) [AID2550, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
View
35
[SID49828715]
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
View
36
[SID49828715]
Potency qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
View
37
[SID49828715]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]LuxS [Vibrio harveyi] [gi:166202459]
View
38
[SID49828715]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
View
39
[SID49828715]
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
View
40
[SID49828715]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
View
41
[SID49828715]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
42
[SID49828715]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
43
[SID49828715]
Potency qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation [AID540263, Type: confirmatory]importin subunit beta-1 isoform 1 [Homo sapiens] [gi:19923142]
View
44
[SID49828715]
Potency qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]importin subunit beta-1 isoform 1 [Homo sapiens] [gi:19923142]
View
45
[SID49828715]
Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_SinglePoint_HTS_Activity [AID488839, Type: screening]Cyclin-dependent kinase 5, regulatory subunit 1 (p35) [Homo sapiens] [gi:20072248]
View
46
[SID49828715]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
View
47
[SID49828715]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
View
48
[SID49828715]
Potency HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
View
49
[SID49828715]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
View
50
[SID49828715]
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View