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AGN-PC-04RYO8 (CID 24819388) - Compound BioActivity Data
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BioActivity Outcomes:
Active(39)
 
 
Inactive(480)
 
 
Inconclusive(18)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(15)
 
 
KCNQ channel(8)
 
 
 
RING(5)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(371)
 
 
 
 
Confirmatory(151)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(111)
 
 
 
 
 
IC50(31)
 
 
 
 
EC50(4)
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 492    Data Row: 538   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49826545]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID49826545]
AC50_uM 3.478Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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3
[SID49826545]
Potency 4.1095qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID49826545]
Potency 4.4668qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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5
[SID49826545]
AC50_uM 4.624ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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6
[SID49826545]
Potency 7.0795VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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7
[SID49826545]
IC50_Mean 10.6Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602464, Type: confirmatory]Gli1 [Mus musculus] [gi:6009644]
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8
[SID49826545]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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9
[SID49826545]
Potency 15.1014qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID49826545]
Potency 19.9526qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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11
[SID49826545]
Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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12
[SID49826545]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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13
[SID49826545]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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14
[SID49826545]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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15
[SID49826545]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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16
[SID49826545]
Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): Luminescence-based cell-based high throughput screening assay to identify agonists of the Herpes Virus Virion Protein 16 (VP16) [AID624379, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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17
[SID49826545]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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18
[SID49826545]
Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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19
[SID49826545]
Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651994, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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20
[SID49826545]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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