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T6098872 (CID 24818225) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(486)
 
 
Inconclusive(20)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(16)
 
 
 
KCNQ channel(9)
 
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(374)
 
 
 
 
Confirmatory(146)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(112)
 
 
 
 
 
IC50(28)
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 491    Data Row: 531   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49821059]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID49821059]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID49821059]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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4
[SID49821059]
Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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5
[SID49821059]
Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based primary cell-based high throughput assay to identify agonists of the vasopressin 1 receptor (V1R) [AID2797, Type: screening]vasopressin V1a receptor [Homo sapiens] [gi:4502331]
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6
[SID49821059]
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [AID602410, Type: screening]Kcnk3 channel [Homo sapiens] [gi:11093520]
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7
[SID49821059]
Confirmation assay for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [Primary Screening] [AID651638, Type: screening]Kcnk3 channel [Homo sapiens] [gi:11093520]
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8
[SID49821059]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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9
[SID49821059]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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10
[SID49821059]
Fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based high throughput screening assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1). [AID2148, Type: screening]melanin-concentrating hormone receptor 1 [Homo sapiens] [gi:88758590]
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11
[SID49821059]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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12
[SID49821059]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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13
[SID49821059]
Validation (re-confirmation) assay for identification of compounds that inhibit KCNQ1 potassium channels [AID588353, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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14
[SID49821059]
Validation for compounds that inhibit KCNQ1 potassium channels on automated electrophysiology assay [AID624120, Type: other]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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15
[SID49821059]
Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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16
[SID49821059]
Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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17
[SID49821059]
Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1861, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
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18
[SID49821059]
Fluorescence-based confirmation cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1952, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
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19
[SID49821059]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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20
[SID49821059]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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21
[SID49821059]
Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]anoctamin-1 isoform 1 [Mus musculus] [gi:334278898]
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22
[SID49821059]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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23
[SID49821059]
Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]potassium voltage-gated channel subfamily E member 1 [Homo sapiens] [gi:189095237]
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24
[SID49821059]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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25
[SID49821059]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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26
[SID49821059]
Potency 14.1254qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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27
[SID49821059]
Potency 28.1838qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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28
[SID49821059]
Potency 31.6228qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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29
[SID49821059]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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30
[SID49821059]
Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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31
[SID49821059]
uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] [gi:90652859]
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32
[SID49821059]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL) [AID2751, Type: screening]Prolyl endopeptidase-like [Homo sapiens] [gi:153217451]
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33
[SID49821059]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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34
[SID49821059]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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35
[SID49821059]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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36
[SID49821059]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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37
[SID49821059]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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38
[SID49821059]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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39
[SID49821059]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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40
[SID49821059]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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41
[SID49821059]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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42
[SID49821059]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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43
[SID49821059]
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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44
[SID49821059]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID588354, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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45
[SID49821059]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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46
[SID49821059]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3). [AID720704, Type: screening]Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [gi:148745659]
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47
[SID49821059]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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48
[SID49821059]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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49
[SID49821059]
Potentiators of Human D1 Dopamine Receptor: qHTS [AID504651, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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50
[SID49821059]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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