T6100654 (CID 24818119) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(14)
 
 
Inactive(428)
 
 
Inconclusive(12)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
Pyruvate Kina..(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(314)
 
 
 
 
Confirmatory(132)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(25)
 
 
EC50(4)
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 455    Data Row: 455   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49820648]
Potency 4.1095Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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2
[SID49820648]
Potency 4.1095Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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3
[SID49820648]
Potency 4.1095Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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4
[SID49820648]
Potency 4.1095Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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5
[SID49820648]
Potency 11.2202qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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6
[SID49820648]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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7
[SID49820648]
Potency 14.7157Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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8
[SID49820648]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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9
[SID49820648]
Potency 35.4813qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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10
[SID49820648]
 Turbidometric Biochemical Primary HTS to identify inhibitors of ERp5 Measured in Biochemical System Using Plate Reader - 7002-01_Inhibitor_SinglePoint_HTS_Activity [AID651711, Type: screening]Protein disulfide-isomerase A6 [gi:2501205]
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11
[SID49820648]
 Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
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12
[SID49820648]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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13
[SID49820648]
 Luminescence-based biochemical high throughput confirmation assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624412, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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14
[SID49820648]
 Fluorescent Polarization-based biochemical high throughput orthogonal assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID651607, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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15
[SID49820648]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]
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16
[SID49820648]
 Counterscreen for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS): Luminescence-based cell-based high throughput assay to identify compounds that are cytotoxic to Jurkat human T lymphocyte cells [AID624413, Type: screening]
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17
[SID49820648]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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18
[SID49820648]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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19
[SID49820648]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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20
[SID49820648]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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21
[SID49820648]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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22
[SID49820648]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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23
[SID49820648]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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24
[SID49820648]
Potency 7.3048qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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25
[SID49820648]
 uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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26
[SID49820648]
 uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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27
[SID49820648]
IC50 Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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28
[SID49820648]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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29
[SID49820648]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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30
[SID49820648]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the Epstein-Barr virus nuclear antigen 1 (EBNA-1). [AID1950, Type: screening]EBNA-1 protein [Human herpesvirus 4] [gi:23893623]
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31
[SID49820648]
 Counterscreen for inhibitors of EBNA-1: fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of the Epstein-Barr virus-encoded protein, ZTA. [AID2234, Type: screening]BZLF1 [Human herpesvirus 4] [gi:82503229]
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32
[SID49820648]
 Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
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33
[SID49820648]
Potency qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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34
[SID49820648]
 Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
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35
[SID49820648]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set [AID588499, Type: Literature]botulinum neurotoxin type A [Clostridium botulinum A str. ATCC 3502] [gi:148378801]
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36
[SID49820648]
 Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_SinglePoint_HTS_Activity [AID488965, Type: screening]pvdQ gene product [Pseudomonas aeruginosa LESB58] [gi:218891639]
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37
[SID49820648]
 Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_Activity [AID602481, Type: screening]bioA [Mycobacterium tuberculosis UT205] [gi:378544807]
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38
[SID49820648]
 Fluorescence polarization to screen for inhibitor that competite the binding of FadD28 to bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_SinglePoint_HTS_Activity [AID588549, Type: screening]FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) [Mycobacterium tu [gi:1781172]
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39
[SID49820648]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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40
[SID49820648]
 Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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41
[SID49820648]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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42
[SID49820648]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2 [Saccharomyces cerevisiae] [gi:171229]
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43
[SID49820648]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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44
[SID49820648]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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45
[SID49820648]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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46
[SID49820648]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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47
[SID49820648]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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48
[SID49820648]
AC50 High Throughput Screen for Tat Transport Inhibitors Measured in Microorganism System Using Plate Reader - 2093-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504941, Type: confirmatory]TatABCE protein translocation system subunit [Escherichia coli str. K-12 substr. MG1655] [gi:90111653]
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49
[SID49820648]
 uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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50
[SID49820648]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set [AID588501, Type: Literature]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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