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TRIMETHYL GLYCINE (CID 248) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(137)
 
 
Inconclusive(8)
 
 
Unspecified(32)
 
 
Top Targets:
p450(9)
 
 
7TM GPCR Srx(6)
 
 
HSD10-like SD..(4)
 
 
Pyr redox dim(4)
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Confirmatory(129)
 
 
 
Literature(34)
 
 
 
 
BioActivity Types:
Potency(108)
 
 
 
Ki(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 165    Data Row: 180   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46393177]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Prox From Archeoglobus Fulgidus In Complex With Glycine Betaine [gi:55669782]
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2
[SID46393060]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Analysis Of Prox In Complex With Glycine Betaine [gi:46015450]
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3
[SID46393864]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of The Binding Protein Opuac In Complex With Glycine Betaine [gi:93278789]
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4
[SID103312672]
Ki 1900Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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5
[SID103312672]
IC50 8000Inhibitory activity against Plasmodium falciparum [AID158688, Type: Literature]
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6
[SID103312672]
Osmoprotective activity of compound in Rhizobium meliloti 102F34 by restoring its growth rate was evaluated; Highly osmoprotective [AID200206, Type: other]
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7
[SID103312672]
Tested for effect on doubling time of growth of Sinorhizobium meliloti 102F34 in Lactate aspartate(LAS) minimal medium (with addition of NaCl) [AID204967, Type: Literature]
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8
[SID103312672]
Tested for effect on doubling time of growth of Sinorhizobium meliloti 102F34 in Lactate aspartate(LAS) minimal medium (without addition of NaCl) [AID204968, Type: Literature]
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9
[SID103312672]
Maximal attenuance reached in the stationary phase was reported against Sinorhizobium meliloti 102F34 in Lactate aspartate(LAS) minimal medium (with addition of NaCl) [AID204969, Type: Literature]
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10
[SID103312672]
Maximal attenuance reached in the stationary phase was reported against Sinorhizobium meliloti 102F34 in Lactate aspartate(LAS) minimal medium (without addition of NaCl) [AID204970, Type: Literature]
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11
[SID103312672]
Evaluated for substrate specificity of betaine uptake in salt-stressed Sinorhizobium meliloti. compound to substrate ratio 100:1 [AID229696, Type: Literature]
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12
[SID103312672]
Evaluated for substrate specificity of betaine uptake in salt-stressed Sinorhizobium meliloti. compound to substrate ratio 10:1 [AID229697, Type: Literature]
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13
[SID103312672]
Evaluated for substrate specificity of betaine uptake in salt-stressed Sinorhizobium meliloti. compound to substrate ratio 1:1 [AID229698, Type: Literature]
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14
[SID103312672]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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15
[SID103312672]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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16
[SID103312672]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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17
[SID103312672]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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18
[SID103312672]
FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI [AID625278, Type: Literature]
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19
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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20
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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21
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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22
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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23
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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24
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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25
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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26
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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27
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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28
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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29
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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30
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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31
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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32
[SID103312672]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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33
[SID11110845]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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34
[SID103312672]
Inhibitory activity against growth of Escherichia coli MC4100 in presence 0.8M NaCl; Strong inhibition [AID71041, Type: other]
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35
[SID103312672]
TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.025 uM, Betaine: 500 uM) in OCTN2-expressing HRPE cells [AID681713, Type: other]Solute carrier family 22 member 5 [gi:8928242]
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36
[SID174007375]
Potency 0.1058qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
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37
[SID90341438]
Potency 0.1683qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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38
[SID174007375]
Potency 1.495qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2) [AID743346, Type: confirmatory]
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39
[SID174007375]
Potency 13.3244qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation [AID743347, Type: confirmatory]
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40
[SID11110845]
AP1 Signaling Pathway [AID357, Type: confirmatory]
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41
[SID11110845]
NFAT Signaling Pathway [AID444, Type: confirmatory]
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42
[SID11110845]
Stat Signaling Pathway [AID446, Type: confirmatory]
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43
[SID11110845]
qHTS Assay for Spectroscopic Profiling in Resorufin Spectral Region [AID588, Type: other]
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44
[SID11110845]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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45
[SID11110845]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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46
[SID11110845]
qHTS Assay for Spectroscopic Profiling in A488 Spectral Region [AID591, Type: other]
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47
[SID11110845]
qHTS Assay for Spectroscopic Profiling in A647 Spectral Region [AID592, Type: other]
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48
[SID11110845]
qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region [AID593, Type: other]
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49
[SID11110845]
qHTS Assay for Spectroscopic Profiling in Rhodamine Spectral Region [AID594, Type: confirmatory]
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50
[SID11110845]
qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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