Dafadine-A (CID 24790866) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(20)
 
 
Inactive(427)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
KCNQ channel(8)
 
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
NR LBD Tlx PN..(4)
 
 
 
BioAssay Types:
Screening(320)
 
 
 
 
Confirmatory(132)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(27)
 
 
 
 
EC50(6)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 463    Data Row: 463   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49719293]
IC50 2.08Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID624395, Type: confirmatory]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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2
[SID49719293]
Potency 5.1735qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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3
[SID49719293]
IC50 6.23Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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4
[SID49719293]
IC50 6.23Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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5
[SID49719293]
IC50 6.23Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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6
[SID49719293]
Potency 7.9433qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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7
[SID49719293]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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8
[SID49719293]
Potency 13.4591qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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9
[SID49719293]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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10
[SID49719293]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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11
[SID49719293]
 Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]
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12
[SID49719293]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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13
[SID49719293]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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14
[SID49719293]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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15
[SID49719293]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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16
[SID49719293]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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17
[SID49719293]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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18
[SID49719293]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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19
[SID49719293]
 Luminescence-based cell-based high throughput confirmation assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624378, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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20
[SID49719293]
 Luminescence-based cell-based high throughput confirmation assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624378, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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21
[SID49719293]
 Luminescence-based cell-based high throughput confirmation assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624378, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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22
[SID49719293]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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23
[SID49719293]
 Validation (re-confirmation) assay for identification of compounds that inhibit KCNQ1 potassium channels [AID588353, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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24
[SID49719293]
 uHTS identification of small molecule activators of alpha dystroglycan glycosylation [AID624168, Type: screening]LARGE [Homo sapiens] [gi:47678551]
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25
[SID49719293]
 Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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26
[SID49719293]
 Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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27
[SID49719293]
 Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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28
[SID49719293]
 Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
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29
[SID49719293]
 Re-confirmation assay for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID652189, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
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30
[SID49719293]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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31
[SID49719293]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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32
[SID49719293]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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33
[SID49719293]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID49719293]
Potency 11.2202qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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35
[SID49719293]
Potency 35.4813qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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36
[SID49719293]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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37
[SID49719293]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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38
[SID49719293]
EC50 112.219Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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39
[SID49719293]
EC50 112.219Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase [AID1891, Type: confirmatory]
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40
[SID49719293]
 Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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41
[SID49719293]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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42
[SID49719293]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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43
[SID49719293]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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44
[SID49719293]
Potency qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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45
[SID49719293]
Potency qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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46
[SID49719293]
 uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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47
[SID49719293]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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48
[SID49719293]
Potency qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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49
[SID49719293]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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50
[SID49719293]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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