MLS000950531 (CID 24789846) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(23)
 
 
Inactive(304)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
KCNQ channel(8)
 
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
Peptidase C48(3)
 
 
BioAssay Types:
Screening(204)
 
 
 
 
Confirmatory(129)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(94)
 
 
 
 
 
IC50(21)
 
 
EC50(10)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 341    Data Row: 341   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49716357]
EC50 0.99Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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2
[SID49716357]
EC50 4.278Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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3
[SID49716357]
EC50 7.363Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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4
[SID49716357]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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5
[SID49716357]
EC50 11.178Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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6
[SID49716357]
EC50 11.986Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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7
[SID49716357]
Potency 15.8489qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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8
[SID49716357]
CC50 16.44An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) [AID2410, Type: confirmatory]
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9
[SID49716357]
EC50 18.469Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression [AID1914, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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10
[SID49716357]
CC50 37.57A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Sensitize Mycobacterium Tuberculosis to Beta-Lactam Antibiotics [AID434958, Type: confirmatory]
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11
[SID49716357]
Potency 44.6684qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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12
[SID49716357]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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13
[SID49716357]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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14
[SID49716357]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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15
[SID49716357]
 uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
View
16
[SID49716357]
 Confirmatory screen for identification of compounds that inhibit the two-pore domain potassium channel (KCNK9) [AID492992, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
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17
[SID49716357]
 Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 [AID488922, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
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18
[SID49716357]
 Validation (re-confirmation) assay for identification of compounds that inhibit KCNQ1 potassium channels [AID588353, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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19
[SID49716357]
 Counter screen assay of the parental CHO cells for identification of compounds that inhibit KCNQ1 potassium channels [AID588366, Type: other]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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20
[SID49716357]
 MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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21
[SID49716357]
 Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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22
[SID49716357]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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23
[SID49716357]
 QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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24
[SID49716357]
 QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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25
[SID49716357]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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26
[SID49716357]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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27
[SID49716357]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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28
[SID49716357]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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29
[SID49716357]
Potency 25.1189qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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30
[SID49716357]
IC50 100Screen and Counter Screen to Identify Novel Compounds that Selectively Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434987, Type: confirmatory]
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31
[SID49716357]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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32
[SID49716357]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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33
[SID49716357]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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34
[SID49716357]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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35
[SID49716357]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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36
[SID49716357]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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37
[SID49716357]
 Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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38
[SID49716357]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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39
[SID49716357]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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40
[SID49716357]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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41
[SID49716357]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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42
[SID49716357]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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43
[SID49716357]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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44
[SID49716357]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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45
[SID49716357]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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46
[SID49716357]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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47
[SID49716357]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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48
[SID49716357]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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49
[SID49716357]
 Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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50
[SID49716357]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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