Bookmark and Share
MLS000829935 (CID 24789249) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(59)
 
 
Inactive(516)
 
 
Inconclusive(43)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
7TM GPCR Srsx(17)
 
 
 
Pyruvate Kina..(8)
 
 
 
ANK(7)
 
 
 
 
STKc MAP4K3 l..(6)
 
 
 
BioAssay Types:
Screening(388)
 
 
 
 
Confirmatory(220)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(163)
 
 
 
 
 
IC50(31)
 
 
 
 
EC50(20)
 
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 514    Data Row: 619   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49713822]
IC50 1.85397Image-Based HTS for Selective Antagonists for GPR55 [AID2013, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
View
2
[SID49713822]
EC50 4.9Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast [AID1935, Type: confirmatory]
View
3
[SID49713822]
EC50 5.3A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
View
4
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
5
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
6
[SID50126041]
Potency 6.5733Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
7
[SID49713822]
AC50_uM 6.826Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
View
8
[SID49713822]
EC50_MICROM 7.03Dose Response Confirmation via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1897, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
View
9
[SID49713822]
AC50_uM 8.068ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
View
10
[SID49713822]
EC50 8.283Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
View
11
[SID49713822]
EC50 9.709Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE) [AID588439, Type: confirmatory]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
View
12
[SID49713822]
EC50 11.023Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
View
13
[SID49713822]
Potency 11.5821A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
View
14
[SID49713822]
Potency 12.5893qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
View
15
[SID49713822]
EC50_MICROM 13.77Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant [AID1895, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
View
16
[SID49713822]
Potency 14.1254qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
17
[SID49713822]
Potency 17.7828qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
View
18
[SID49713822]
Potency 22.3872qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
View
19
[SID49713822]
IC50 33.31A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
View
20
[SID49713822]
IC50 35.3A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
View
21
[SID50126041]
Potency 56.2341qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
22
[SID49713822]
Potency 79.4328qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
23
[SID49713822]
IC50 86.107A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
View
24
[SID49713822]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
View
25
[SID49713822]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
View
26
[SID49713822]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
View
27
[SID49713822]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
View
28
[SID49713822]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
View
29
[SID49713822]
MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
View
30
[SID49713822]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720543, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
View
31
[SID49713822]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720658, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
View
32
[SID49713822]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
View
33
[SID49713822]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
View
34
[SID49713822]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
35
[SID49713822]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
View
36
[SID49713822]
Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1861, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
View
37
[SID49713822]
Fluorescence-based confirmation cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1952, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
View
38
[SID49713822]
Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID651958, Type: screening]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
View
39
[SID49713822]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
View
40
[SID49713822]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
View
41
[SID49713822]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
View
42
[SID49713822]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
View
43
[SID49713822]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
View
44
[SID49713822]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
45
[SID49713822]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
View
46
[SID49713822]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase 2 mutant [AID1530, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
View
47
[SID49713822]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1531, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
View
48
[SID49713822]
Single Concentration Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1892, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
View
49
[SID49713822]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
View
50
[SID49713822]
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
View