MLS000829935 (CID 24789249) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(50)
 
 
Inactive(439)
 
 
Inconclusive(37)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
7TM GPCR Srsx(8)
 
 
 
Pyruvate Kina..(8)
 
 
 
STKc MAP4K3 l..(6)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(323)
 
 
 
 
Confirmatory(193)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(139)
 
 
 
 
 
IC50(28)
 
 
 
 
EC50(20)
 
 
 
 
AC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 473    Data Row: 527   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49713822]
IC50 1.85397Image-Based HTS for Selective Antagonists for GPR55 [AID2013, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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2
[SID49713822]
EC50 4.9Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast [AID1935, Type: confirmatory]
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3
[SID49713822]
EC50 5.3A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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4
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID49713822]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID50126041]
Potency 6.5733Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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11
[SID49713822]
AC50 6.826Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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12
[SID49713822]
EC50 7.03Dose Response Confirmation via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1897, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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13
[SID49713822]
EC50 7.03Dose Response Confirmation via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1897, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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14
[SID49713822]
AC50 8.068ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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15
[SID49713822]
EC50 8.283Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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16
[SID49713822]
EC50 9.709Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE) [AID588439, Type: confirmatory]IDE gene product [Homo sapiens] [gi:155969707]
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17
[SID49713822]
EC50 11.023Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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18
[SID49713822]
Potency 11.5821A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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19
[SID49713822]
EC50 13.77Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant [AID1895, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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20
[SID49713822]
EC50 13.77Dose Response Confirmation Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Mutant [AID1895, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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21
[SID49713822]
Potency 14.1254qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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22
[SID49713822]
Potency 17.7828qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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23
[SID49713822]
Potency 22.3872qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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24
[SID49713822]
IC50 33.31A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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25
[SID49713822]
IC50 35.3A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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26
[SID50126041]
Potency 56.2341qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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27
[SID49713822]
Potency 79.4328qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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28
[SID49713822]
IC50 86.107A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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29
[SID49713822]
 MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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30
[SID49713822]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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31
[SID49713822]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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32
[SID49713822]
 uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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33
[SID49713822]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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34
[SID49713822]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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35
[SID49713822]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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36
[SID49713822]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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37
[SID49713822]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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38
[SID49713822]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
39
[SID49713822]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
View
40
[SID49713822]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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41
[SID49713822]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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42
[SID49713822]
 Fluorescence-based confirmation cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1952, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
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43
[SID49713822]
 Fluorescence-based confirmation cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1952, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
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44
[SID49713822]
 Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1861, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
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45
[SID49713822]
 Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). [AID1861, Type: screening]neuropeptides B/W receptor 1 [Homo sapiens] [gi:119607128]
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46
[SID49713822]
 Fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based high throughput screening assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1). [AID2148, Type: screening]melanin-concentrating hormone receptor 1 [Homo sapiens] [gi:88758590]
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47
[SID49713822]
 Fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based high throughput screening assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1). [AID2148, Type: screening]melanin-concentrating hormone receptor 1 [Homo sapiens] [gi:88758590]
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48
[SID49713822]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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49
[SID49713822]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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50
[SID49713822]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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