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Buspirone (CID 2477) - Compound BioActivity Data
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BioActivity Outcomes:
Active(146)
 
 
Inactive(559)
 
 
Inconclusive(93)
 
 
Unspecified(309)
 
 
Top Targets:
7TM GPCR Srx(52)
 
 
 
 
 
p450(46)
 
 
 
 
7TM GPCR Srsx(36)
 
 
 
 
NR LBD PPAR(16)
 
 
 
NR LBD ER(16)
 
 
 
 
 
BioAssay Types:
Confirmatory(488)
 
 
 
 
Literature(368)
 
 
 
 
 
Summary(48)
 
 
 
 
Screening(25)
 
 
BioActivity Types:
Potency(454)
 
 
 
 
IC50(180)
 
 
 
 
Ki(68)
 
 
 
Kd(2)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 708    Data Row: 1107   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166970]
Ki 0.0031Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of bovine hippocampus. [AID3471, Type: Literature]
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2
[SID103166970]
Ki 0.0038Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes [AID394123, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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3
[SID103166970]
Ki 0.005Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus [AID4362, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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4
[SID103166970]
Ki 0.005Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101 [AID4042, Type: Literature]
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5
[SID103166970]
Ki 0.0066Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus. [AID3474, Type: Literature]
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6
[SID103166970]
Ki 0.007Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranes [AID3470, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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7
[SID103166970]
IC50 0.00713Binding affinity towards 5-hydroxytryptamine 1A receptor using receptor binding assay [AID4137, Type: other]
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8
[SID103166970]
Ki 0.0086Binding affinity of compound towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT (0.5 nM) ligand in hippocampus + frontal bovine was determined [AID3472, Type: Literature]
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9
[SID103166970]
Ki 0.0093Binding affinity against rat 5-hydroxytryptamine 1A receptor [AID4220, Type: Literature]
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10
[SID103166970]
Ki 0.01In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue. [AID4322, Type: Literature]
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11
[SID103166970]
Ki 0.01Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor [AID4331, Type: Literature]
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12
[SID103166970]
Ki 0.01In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus [AID4076, Type: Literature]
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13
[SID103166970]
Kd 0.01Binding affinity to 5HT1A receptor [AID438555, Type: Literature]
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14
[SID103166970]
IC50 0.011Inhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligand [AID242367, Type: Literature]
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15
[SID103166970]
IC50 0.011Binding affinity to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]8-OH-DPAT as radioligand [AID3729, Type: Literature]
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16
[SID103166970]
Ki 0.0123Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]8-OH-DPAT [AID4015, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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17
[SID103166970]
IC50 0.0128In vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex [AID3751, Type: Literature]
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18
[SID103166970]
IC50 0.0128In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand. [AID3757, Type: Literature]
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19
[SID103166970]
Ki 0.013Displacement of [3H]U-86170 from human D2-dopamine receptor expressed in CHO K1 cells [AID63410, Type: Literature]D(2) dopamine receptor [gi:118206]
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20
[SID103166970]
Ki 0.013Binding affinity to D2 receptor by radioligand binding assay [AID265217, Type: Literature]D(2) dopamine receptor [gi:118206]
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21
[SID103166970]
Ki 0.0138Inhibitory affinity constant against 5-hydroxytryptamine 1A receptor [AID4332, Type: Literature]
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22
[SID103166970]
Ki 0.015Binding affinity by measuring displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampus [AID4005, Type: Literature]
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23
[SID103166970]
Ki 0.015Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain [AID4095, Type: Literature]
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24
[SID103166970]
Ki 0.015Binding affinity against human 5-hydroxytryptamine 1A receptor [AID3802, Type: Literature]
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25
[SID103166970]
Ki 0.015Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand [AID4023, Type: Literature]
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26
[SID103166970]
Ki 0.015Displacement of [3H]8-OH-DPAT from human 5HT1A receptor [AID392707, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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27
[SID103166970]
Ki 0.015Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus [AID343002, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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28
[SID103166970]
Ki 0.0154In vitro ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex. [AID4073, Type: Literature]
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29
[SID103166970]
IC50 0.016DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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30
[SID103166970]
Ki 0.017Inhibition of [3H]5-HT binding to 5-hydroxytryptamine 1B receptor [AID4691, Type: Literature]5-hydroxytryptamine receptor 1B [gi:112815]
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31
[SID103166970]
Ki 0.017Affinity for 5HT1A receptor [AID267572, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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32
[SID103166970]
Ki 0.02Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cells [AID265214, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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33
[SID103166970]
Ki 0.02Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cells by liquid scintillation counting [AID460125, Type: Literature]
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34
[SID103166970]
Ki 0.0205Binding affinity at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes by [3H]8-OH-DPAT displacement. [AID4056, Type: other]
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35
[SID103166970]
Ki 0.0205Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand. [AID4062, Type: Literature]
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36
[SID103166970]
Ki 0.021Displacement of [3H]5-carboxamidotryptamine to human 5HT1A expressed in HEK293 cells by filter binding assay [AID712521, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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37
[SID103166970]
IC50 0.024In vitro binding affinity towards the 5-hydroxytryptamine 1A receptor was evaluated [AID3759, Type: Literature]
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38
[SID103166970]
Ki 0.024Binding affinity to 5HT1A receptor [AID460124, Type: Literature]
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39
[SID103166970]
IC50 0.025In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT in human CYP3A4 assay [AID3589, Type: Literature]
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40
[SID103166970]
IC50 0.03Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand [AID3725, Type: Literature]
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41
[SID103166970]
IC50 0.03Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand [AID3726, Type: Literature]
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42
[SID103166970]
Ki 0.032Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes [AID4024, Type: Literature]
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43
[SID103166970]
Ki 0.036Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membrane [AID416912, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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44
[SID103166970]
EC50 0.041Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR [AID392709, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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45
[SID103166970]
IC50 0.044DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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46
[SID103166970]
Ki 0.044Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatum [AID62343, Type: Literature]D(2) dopamine receptor [gi:118205]
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47
[SID103166970]
Ki 0.0461Binding affinity for 5-hydroxytryptamine 1A receptor with [3H]5-HT [AID4000, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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48
[SID103166970]
Ki 0.048Inhibition of [3H]DTG binding to sigma receptor in rat hippocampus [AID204612, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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49
[SID103166970]
IC50 0.05In vitro inhibition of [3H]8-OH-DPAT binding to rat 5-HT 1a receptors. [AID3745, Type: Literature]
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50
[SID103166970]
IC50 0.052Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus [AID3768, Type: Literature]
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