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Buspirone (CID 2477) - Compound BioActivity Data
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BioActivity Outcomes:
Active(148)
 
 
Inactive(567)
 
 
Inconclusive(88)
 
 
Unspecified(476)
 
 
Top Targets:
7TM GPCR Srx(55)
 
 
 
 
 
p450(46)
 
 
 
 
7TM GPCR Srsx(36)
 
 
 
 
NR LBD PPAR(16)
 
 
 
NR LBD ER(16)
 
 
 
 
 
BioAssay Types:
Confirmatory(611)
 
 
 
 
 
Literature(374)
 
 
 
 
 
Summary(48)
 
 
 
 
Screening(25)
 
 
BioActivity Types:
Potency(456)
 
 
 
 
IC50(180)
 
 
 
 
Ki(69)
 
 
 
Kd(2)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 877    Data Row: 1279   Total Pages: 64   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166970]
Ki 0.0031Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of bovine hippocampus. [AID3471, Type: Literature]
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2
[SID103166970]
Ki 0.0038Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes [AID394123, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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3
[SID103166970]
Ki 0.005Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus [AID4362, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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4
[SID103166970]
Ki 0.005Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101 [AID4042, Type: Literature]
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5
[SID103166970]
Ki 0.0066Ability to displace [3H]-DPAT from 5-hydroxytryptamine 1A receptor in homogenates of bovine hippocampus. [AID3474, Type: Literature]
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6
[SID103166970]
Ki 0.007Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranes [AID3470, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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7
[SID103166970]
IC50 0.00713Binding affinity towards 5-hydroxytryptamine 1A receptor using receptor binding assay [AID4137, Type: confirmatory]
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8
[SID103166970]
Ki 0.0086Binding affinity of compound towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT (0.5 nM) ligand in hippocampus + frontal bovine was determined [AID3472, Type: Literature]
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9
[SID103166970]
Ki 0.0093Binding affinity against rat 5-hydroxytryptamine 1A receptor [AID4220, Type: Literature]
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10
[SID103166970]
Ki 0.01Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor [AID4331, Type: Literature]
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11
[SID103166970]
Ki 0.01In vitro inhibition of [3H]spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue. [AID4322, Type: Literature]
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12
[SID103166970]
Ki 0.01In vitro ability to inhibit [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat hippocampus [AID4076, Type: Literature]
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13
[SID103166970]
Kd 0.01Binding affinity to 5HT1A receptor [AID438555, Type: Literature]
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14
[SID103166970]
IC50 0.011Inhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligand [AID242367, Type: Literature]
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15
[SID103166970]
IC50 0.011Binding affinity to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]8-OH-DPAT as radioligand [AID3729, Type: Literature]
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16
[SID103166970]
Ki 0.012Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr [AID759366, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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17
[SID103166970]
Ki 0.0123Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]8-OH-DPAT [AID4015, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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18
[SID103166970]
IC50 0.0128In vitro ability to inhibit binding of radioligand [3H]8-OH-DPAT to 5-hydroxytryptamine 1A receptor in rat cerebral cortex [AID3751, Type: Literature]
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19
[SID103166970]
IC50 0.0128In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand. [AID3757, Type: Literature]
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20
[SID103166970]
Ki 0.013Displacement of [3H]U-86170 from human D2-dopamine receptor expressed in CHO K1 cells [AID63410, Type: Literature]D(2) dopamine receptor [gi:118206]
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