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4-(7-Methyl-imidazo[1,2-a]pyridin-2-yl)-benzene-1,2-diol (CID 24761099) - Compound BioActivity Data
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BioActivity Outcomes:
Active(59)
 
 
Inactive(483)
 
 
Inconclusive(26)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(37)
 
 
 
TRP 2(9)
 
 
 
alkPPc(6)
 
 
 
Bcl-2 like(5)
 
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(384)
 
 
 
 
Confirmatory(169)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(118)
 
 
 
 
 
IC50(31)
 
 
 
 
EC50(13)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 520    Data Row: 569   Total Pages: 29   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49665524]
AC50_uM 0.558HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity [AID493248, Type: confirmatory]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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2
[SID49665524]
AC50_uM 2.44Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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3
[SID49665524]
Potency 2.5119qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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4
[SID49665524]
Potency 3.0131qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID49665524]
Potency 3.2629qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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6
[SID49665524]
EC50_Mean 5.31Dose response confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489024, Type: confirmatory]
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7
[SID49665524]
EC50 6.575Luminescent Cell-Based Dose Titration Retest Counterscreen to Identify Proteasome Inhibitors [AID2486, Type: confirmatory]
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8
[SID49665524]
EC50 6.882Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex-5 [gi:55976631]
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9
[SID49665524]
IC50 7.1A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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10
[SID49665524]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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11
[SID49665524]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID49665524]
Potency 10qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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13
[SID49665524]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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14
[SID49665524]
Potency 12.5893VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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15
[SID49665524]
IC50 12.89Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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16
[SID49665524]
AC50_uM 12.98Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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17
[SID49665524]
Potency 14.1254qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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18
[SID49665524]
AC50_uM 15.78Luminescence assay for the detection of hydrogen peroxide activity in the abscence of ALR and DTT, at dose Measured in Biochemical System Using Plate Reader - 2036-03_Inhibitor_Dose_CherryPick_Activity [AID540356, Type: confirmatory]
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19
[SID49665524]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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20
[SID49665524]
Potency 19.9526qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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