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MLS001164888 (CID 24761053) - Compound BioActivity Data
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BioActivity Outcomes:
Active(107)
 
 
Inactive(436)
 
 
Inconclusive(32)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(15)
 
 
 
TRP 2(9)
 
 
 
CAP ED(5)
 
 
B zip1(5)
 
 
 
 
BioAssay Types:
Screening(391)
 
 
 
 
Confirmatory(170)
 
 
 
 
 
Literature(6)
 
 
 
BioActivity Types:
Potency(123)
 
 
 
 
 
IC50(31)
 
 
 
 
EC50(9)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 531    Data Row: 576   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49664925]
Potency 0.1169Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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2
[SID49664925]
Potency 0.1312Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID49664925]
EC50_uM 2.38Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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4
[SID49664925]
AC50_uM 3.35VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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5
[SID49664925]
EC50 3.534Absorbance-based biochemical high throughput dose response assay for activators of Methionine sulfoxide reductase A (MsrA) [AID623963, Type: confirmatory]MSRA protein [Bos taurus] [gi:73586699]
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6
[SID49664925]
Potency 3.5481qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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7
[SID49664925]
EC50_MICROM 4.52Confirmation dose response of additional hit compounds from high-throughput yeast screen for caloric restriction mimetics that inhibit age-related superoxide. [AID504927, Type: confirmatory]
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8
[SID49664925]
Potency 4.7444qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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9
[SID137291996]
EC50 4.926Late stage absorbance-based biochemical dose response assay for activators of Methionine sulfoxide reductase A (MsrA) [AID624497, Type: confirmatory]MSRA protein [Bos taurus] [gi:73586699]
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10
[SID49664925]
IC50 5.962Fluorescence-based biochemical high throughput screening dose response assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID720578, Type: confirmatory]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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11
[SID49664925]
Potency 7.9433qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction [AID624246, Type: confirmatory]transcriptional regulator ERG isoform 3 [Homo sapiens] [gi:343478176]
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12
[SID49664925]
Potency 8.1961qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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13
[SID49664925]
Potency 10qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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14
[SID49664925]
AC50_uM 10.05Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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15
[SID49664925]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID49664925]
IC50_MT1-MMP(HT1080)_Mean 10.5Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluorescence assay set 2 [AID652242, Type: confirmatory]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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17
[SID49664925]
EC50_uM 11.85Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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18
[SID49664925]
Potency 12.5893qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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19
[SID49664925]
Potency 12.5893qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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20
[SID49664925]
Potency 14.1254qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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21
[SID49664925]
Potency 16.3601Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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22
[SID49664925]
Potency 17.7828qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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23
[SID49664925]
Potency 17.7828Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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24
[SID49664925]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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25
[SID49664925]
IC50 18.64Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocysteine [gi:219689243]
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26
[SID49664925]
Potency 19.0115qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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27
[SID49664925]
AC50_uM 19.9Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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28
[SID49664925]
Potency 19.9526qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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29
[SID49664925]
Potency 26.6795qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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30
[SID49664925]
Potency 28.1838qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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31
[SID49664925]
AC50_uM 30.55Fluorescent Polarization Homogeneous Dose Retest to Confirm Inhibitors of Mex-5 Binding to TCR-2 [AID449745, Type: confirmatory]Zinc finger protein mex-5 [gi:55976631]
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32
[SID49664925]
Potency 39.8107HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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33
[SID49664925]
Potency 39.8107qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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34
[SID49664925]
Potency 39.8107qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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35
[SID49664925]
Potency 42.2841qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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36
[SID49664925]
Potency 42.5615qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds [AID720498, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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37
[SID49664925]
Potency 44.6684qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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38
[SID49664925]
Potency 67.4555qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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39
[SID49664925]
Potency 75.193qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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40
[SID49664925]
Potency 79.4328qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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41
[SID49664925]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1). [AID2130, Type: screening]protein phosphatase methylesterase 1 isoform a [Homo sapiens] [gi:7706645]
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42
[SID49664925]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of Protein Phosphatase Methylesterase 1 (PME-1). [AID2171, Type: screening]protein phosphatase methylesterase 1 isoform a [Homo sapiens] [gi:7706645]
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43
[SID49664925]
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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44
[SID49664925]
Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1). [AID2174, Type: screening]acyl-protein thioesterase 1 isoform 1 [Homo sapiens] [gi:5453722]
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45
[SID49664925]
Counterscreen for PME1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of lysophospholipase 1 (LYPLA1). [AID2233, Type: screening]acyl-protein thioesterase 1 isoform 1 [Homo sapiens] [gi:5453722]
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46
[SID49664925]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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47
[SID49664925]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the serine hydrolase family member Fam108B. [AID1947, Type: screening]Fam108b protein [Mus musculus] [gi:21595511]
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48
[SID49664925]
Fluorescence polarization-based confirmation biochemical high throughput screening assay for inhibitors of the serine hydrolase family member Fam108b. [AID1978, Type: screening]Fam108b protein [Mus musculus] [gi:21595511]
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49
[SID49664925]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity [AID2221, Type: screening]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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50
[SID49664925]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720509, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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