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3koo (CID 24748513) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(19)
 
 
Unspecified(8)
 
 
Top Targets:
HAD like(5)
 
 
BioAssay Types:
Literature(27)
 
 
 
BioActivity Types:
IC50(17)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 26    Data Row: 27   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103716704]
IC50 0.011Inhibition of rat soluble epoxide hydrolase [AID484178, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:462371]
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2
[SID103716704]
IC50 0.015Inhibition of human sEH [AID676944, Type: Literature]
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3
[SID103716704]
IC50 0.015Inhibition of human sEH by cell based assay [AID676945, Type: Literature]
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4
[SID103716704]
IC50 0.015Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay [AID453480, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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5
[SID103716704]
IC50 0.015Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA [AID453481, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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6
[SID170483057]
IC50 0.015Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Soluble Epoxide Hydrolase [gi:295321798]
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7
[SID170483057]
IC50 0.015Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Soluble Epoxide Hydrolase [gi:295321798]
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8
[SID103716704]
IC50 0.018Inhibition of human soluble epoxide hydrolase [AID484177, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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9
[SID103716704]
IC50 0.063Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay [AID484176, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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10
[SID103716704]
IC50 19Inhibition of CYP2C19 [AID676948, Type: Literature]
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11
[SID103716704]
IC50 19Inhibition of CYP2C19 [AID453484, Type: Literature]
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12
[SID103716704]
IC50 20Inhibition of CYP2J2 [AID484179, Type: Literature]
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13
[SID103716704]
IC50 20Inhibition of CYP2J2 [AID676946, Type: Literature]
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14
[SID103716704]
IC50 20Inhibition of CYP2C9 [AID676947, Type: Literature]
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15
[SID103716704]
IC50 20Inhibition of CYP2J2 [AID453482, Type: Literature]
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16
[SID103716704]
IC50 20Inhibition of CYP2C9 [AID453483, Type: Literature]
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17
[SID103716704]
IC50 25.5Inhibition of CYP2C9 [AID484180, Type: Literature]
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18
[SID103716704]
Plasma concentration in Sprague-Dawley rat at 5 mg/kg, po after 4 hrs by LC-MS/MS analysis [AID453488, Type: Literature]
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19
[SID103716704]
Plasma concentration in rat at 5 mg/kg, po after 4 hrs [AID676952, Type: Literature]
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20
[SID103716704]
Half life in human liver microsome [AID484181, Type: Literature]
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