SMR000540005 (CID 24747725) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(79)
 
 
Inactive(368)
 
 
Inconclusive(27)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
KCNQ channel(8)
 
 
 
7TM GPCR Srsx(7)
 
 
 
WD40(6)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(306)
 
 
 
 
Confirmatory(160)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(98)
 
 
 
 
 
IC50(36)
 
 
 
 
EC50(15)
 
 
 
 
AC50(8)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 475    Data Row: 475   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49647829]
EC50 1.459Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
View
2
[SID49647829]
Potency 1.7783qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
View
3
[SID49647829]
EC50 2.398Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
4
[SID49647829]
EC50 2.58A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
View
5
[SID49647829]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
View
6
[SID49647829]
IC50 4.77Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID493155, Type: confirmatory]UBE2N gene product [Homo sapiens] [gi:4507793]
View
7
[SID49647829]
IC50 4.77Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID493155, Type: confirmatory]UBE2N gene product [Homo sapiens] [gi:4507793]
View
8
[SID49647829]
IC50 4.771Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm [AID493182, Type: confirmatory]UBE2N gene product [Homo sapiens] [gi:4507793]
View
9
[SID49647829]
IC50 4.771Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm [AID493182, Type: confirmatory]UBE2N gene product [Homo sapiens] [gi:4507793]
View
10
[SID49647829]
AC50 4.774Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
View
11
[SID49647829]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
View
12
[SID49647829]
AC50 6.503Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick [AID488788, Type: confirmatory]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
View
13
[SID49647829]
AC50 6.503Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick [AID488788, Type: confirmatory]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
View
14
[SID49647829]
AC50 6.772HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
View
15
[SID49647829]
AC50 6.772HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
View
16
[SID49647829]
AC50 6.772HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
View
17
[SID49647829]
IC50 7.04High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
View
18
[SID49647829]
AC50 7.069Ste24 Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-03_Inhibitor_Dose_CherryPick_Activity [AID488815, Type: confirmatory]STE24 [Saccharomyces cerevisiae] [gi:1015837]
View
19
[SID49647829]
EC50 7.234Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
View
20
[SID49647829]
AC50 7.995Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
View
21
[SID49647829]
IC50 8.03A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
View
22
[SID49647829]
EC50 8.22Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression [AID1914, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
23
[SID49647829]
IC50 8.26Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen [AID504689, Type: confirmatory]Bcl2a1a gene product [Mus musculus] [gi:11024684]
View
24
[SID49647829]
Potency 9.2683Confirmation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID493168, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
View
25
[SID49647829]
Potency 9.2683Confirmation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID493168, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
View
26
[SID49647829]
EC50 9.478Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
View
27
[SID49647829]
EC50 10.1Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
View
28
[SID49647829]
Potency 11.2202CHOP2 Reporter Counterscreen Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID493169, Type: confirmatory]enteropeptidase precursor [Homo sapiens] [gi:223942069]
View
29
[SID49647829]
IC50 11.6Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
View
30
[SID49647829]
IC50 18.9Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
View
31
[SID49647829]
IC50 18.9Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
View
32
[SID49647829]
IC50 18.9Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
View
33
[SID49647829]
IC50 18.9Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
View
34
[SID49647829]
Potency 19.9526qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
35
[SID49647829]
CC50 25.365A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
View
36
[SID49647829]
IC50 31.447A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
View
37
[SID49647829]
Potency 35.4813qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View
38
[SID49647829]
IC50 38.97A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
View
39
[SID49647829]
Potency 39.8107qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
40
[SID49647829]
IC50 53.55A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
View
41
[SID49647829]
AC50 58.36Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity [AID588849, Type: confirmatory]CAAX prenyl protease 2 isoform 2 [Homo sapiens] [gi:73858575]
View
42
[SID49647829]
AC50 58.36Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity [AID588849, Type: confirmatory]CAAX prenyl protease 2 isoform 2 [Homo sapiens] [gi:73858575]
View
43
[SID49647829]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of Histone Deacetylase 3 [AID2718, Type: screening]histone deacetylase 3 [Homo sapiens] [gi:13128862]
View
44
[SID49647829]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of Histone Deacetylase 3 [AID2718, Type: screening]histone deacetylase 3 [Homo sapiens] [gi:13128862]
View
45
[SID49647829]
 uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
View
46
[SID49647829]
 Single concentration confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID488859, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
View
47
[SID49647829]
 Single concentration confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID488859, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
View
48
[SID49647829]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL) [AID2751, Type: screening]Prolyl endopeptidase-like [Homo sapiens] [gi:153217451]
View
49
[SID49647829]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
View
50
[SID49647829]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
View