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BioActivity Data for Compound MLS001215987 (CID 24747455)

BioActivity Outcomes:
Active(39)
 
 
Inactive(508)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(37)
 
 
Hexokinase 2(6)
 
 
 
ABCC CFTR1(6)
 
 
 
Esterase lipa..(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(380)
 
 
 
Confirmatory(173)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(130)
 
 
 
Toxicity(5)
 
 
Cell-based(115)
 
 
 
Organism-base..(13)
 
 
BioActivity Types:
Potency(118)
 
 
 
 
 
IC50(38)
 
 
 
AC50(7)
 
 
EC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 509    Data Row: 567   Total Pages: 29   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49646259]
Potency 3.1623qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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2
[SID49646259]
IC50_Mean 5.24Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) [AID504729, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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3
[SID49646259]
IC50 7.582QFRET-based dose response biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro) [AID1890, Type: confirmatory]3C-like protease, partial [Infectious bronchitis virus] [gi:73745819]
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4
[SID49646259]
Potency 8.9125qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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5
[SID49646259]
Potency 10qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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6
[SID49646259]
EC50_uM 11Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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7
[SID49646259]
AC50_uM 12.58VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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8
[SID49646259]
AC50_uM 14.33Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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9
[SID49646259]
AC50_uM 18.11Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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10
[SID49646259]
AC50_uM 24.839Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity [AID504773, Type: confirmatory]Golgi-associated PDZ and coiled-coil motif-containing protein isoform b [Homo sapiens] [gi:62868213]
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11
[SID49646259]
AC50_uM 24.839Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity [AID504773, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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12
[SID49646259]
AC50_uM 82.59Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_Dose_CherryPick_Activity [AID602267, Type: confirmatory]Golgi-associated PDZ and coiled-coil motif-containing protein isoform b [Homo sapiens] [gi:62868213]
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13
[SID49646259]
AC50_uM 82.59Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_Dose_CherryPick_Activity [AID602267, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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14
[SID49646259]
EC50_uM 137.9Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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15
[SID49646259]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity [AID2221, Type: screening]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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16
[SID49646259]
IC50 AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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17
[SID49646259]
uHTS HTRF interference counterscreen assay for validation of inhibitors of SUMOylation [AID2069, Type: screening]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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18
[SID49646259]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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19
[SID49646259]
Epi Absorbance-based biochemical high throughput confirmation assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID743263, Type: screening]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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20
[SID49646259]
Confirmation assay for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053136, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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