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4-(6-Methyl-imidazo[1,2-a]pyridin-2-yl)-benzene-1,2-diol (CID 24747132) - Compound BioActivity Data
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BioActivity Outcomes:
Active(58)
 
 
Inactive(487)
 
 
Inconclusive(36)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
Peptidase C48(8)
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
 
BioAssay Types:
Screening(390)
 
 
 
 
Confirmatory(176)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(30)
 
 
 
EC50(12)
 
 
 
AC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 534    Data Row: 582   Total Pages: 30   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49645297]
AC50_uM 0.885HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity [AID493248, Type: confirmatory]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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2
[SID49645297]
AC50_uM 2.47Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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3
[SID49645297]
Potency 3.3808qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID49645297]
Potency 3.5481qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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5
[SID49645297]
EC50_Mean 3.6Dose response confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489024, Type: confirmatory]
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6
[SID49645297]
Potency 3.9811qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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7
[SID49645297]
AC50_uM 4.2Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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8
[SID49645297]
EC50 5.026Luminescent Cell-Based Dose Titration Retest Counterscreen to Identify Proteasome Inhibitors [AID2486, Type: confirmatory]
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9
[SID49645297]
Potency 5.3233qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation [AID540279, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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10
[SID49645297]
EC50 9.701Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex-5 [gi:55976631]
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11
[SID49645297]
AC50_uM 12.04VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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12
[SID49645297]
Potency 19.9526qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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13
[SID49645297]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID49645297]
Potency 22.3872qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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15
[SID49645297]
Potency 22.3872qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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16
[SID49645297]
AC50_uM 22.98Luminescence assay for the detection of hydrogen peroxide activity in the abscence of ALR and DTT, at dose Measured in Biochemical System Using Plate Reader - 2036-03_Inhibitor_Dose_CherryPick_Activity [AID540356, Type: confirmatory]
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17
[SID49645297]
Potency 31.6228qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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18
[SID49645297]
EC50_uM 48.37Fluorescent Cell-Based Secondary Screen to Identify Activators of the Hypoxia Factor Pathway [AID434951, Type: confirmatory]
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19
[SID49645297]
Potency 50.1187qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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20
[SID49645297]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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