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SureCN14413880 (CID 24744859) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Unspecified(4)
 
 
Top Targets:
HAD like(5)
 
 
BioAssay Types:
Literature(13)
 
 
 
BioActivity Types:
IC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 13    Data Row: 13   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103716377]
IC50 0.011Inhibition of human sEH [AID676944, Type: Literature]
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2
[SID103716377]
IC50 0.011Inhibition of rat soluble epoxide hydrolase [AID484178, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:462371]
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3
[SID103716377]
IC50 0.011Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assay [AID453489, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:462371]
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4
[SID103716377]
IC50 0.011Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay [AID453480, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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5
[SID103716377]
IC50 0.012Inhibition of human soluble epoxide hydrolase [AID484177, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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6
[SID103716377]
IC50 0.126Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay [AID484176, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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7
[SID103716377]
IC50 8Inhibition of CYP2C19 [AID453484, Type: Literature]
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8
[SID103716377]
IC50 11Inhibition of CYP2C9 [AID453483, Type: Literature]
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9
[SID103716377]
Plasma concentration in Sprague-Dawley rat at 30 mg/kg, po after 4 hrs by LC-MS/MS analysis [AID453490, Type: Literature]
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10
[SID103716377]
Half life in human liver microsome [AID484181, Type: Literature]
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11
[SID103716377]
Half life in mouse liver microsome [AID484182, Type: Literature]
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12
[SID103716377]
Half life in human liver microsomes after 30 mins by LC-MS/MS analysis in presence of NADPH [AID453485, Type: Literature]
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13
[SID103716377]
Half life in rat liver microsomes after 30 mins by LC-MS/MS analysis in presence of NADPH [AID453486, Type: Literature]
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