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Demeton-S (CID 24723) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(116)
 
 
Inconclusive(8)
 
 
Unspecified(6)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD AR(9)
 
 
NR LBD ER(9)
 
 
 
NR LBD TR(7)
 
 
NR LBD Fxr(6)
 
 
BioAssay Types:
Confirmatory(93)
 
 
 
 
Summary(24)
 
 
Literature(5)
 
 
BioActivity Types:
Potency(111)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 124    Data Row: 132   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26757233]
Potency 44.6684qHTS assay for small molecule agonists of retinoid X receptor alpha signaling [AID588544, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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2
[SID48415498]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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3
[SID194182458]
Resistance index, ratio of bimolecular rate constant Ki for AChE in rganophosphate-resistant clone of Schizaphis graminum OR2 to bimolecular rate constant Ki for AChE in organophosphate-susceptible clone of Schizaphis graminum OSS [AID1101163, Type: Literature]Acetylcholinesterase [gi:75021745]
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4
[SID194182458]
Resistance index, ratio of bimolecular rate constant Ki for AChE in rganophosphate-resistant clone of Schizaphis graminum OR1 to bimolecular rate constant Ki for AChE in organophosphate-susceptible clone of Schizaphis graminum OSS [AID1101164, Type: Literature]Acetylcholinesterase [gi:75021745]
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5
[SID194182458]
Inhibition of AChE in organophosphate-resistant clone of Schizaphis graminum OR2 adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution [AID1101165, Type: Literature]Acetylcholinesterase [gi:75021745]
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6
[SID194182458]
Inhibition of AChE in organophosphate-resistant clone of Schizaphis graminum OR1 adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution [AID1101166, Type: Literature]Acetylcholinesterase [gi:75021745]
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7
[SID194182458]
Inhibition of AChE in organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution [AID1101167, Type: Literature]Acetylcholinesterase [gi:75021745]
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8
[SID26757233]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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9
[SID144207437]
Potency-Replicate_1 65.4629qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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10
[SID144207437]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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11
[SID144207437]
TR Potency (uM) qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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12
[SID144207437]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID144207437]
ER Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID144207437]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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15
[SID144207437]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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16
[SID144207437]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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17
[SID144207437]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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18
[SID144207437]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway [AID743222, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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19
[SID144207437]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway [AID743223, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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20
[SID144207437]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway: Summary [AID743241, Type: summary]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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