bronopol (CID 2450) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(101)
 
 
Inconclusive(18)
 
 
Unspecified(2)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
NR LBD TR(4)
 
 
 
NR LBD VDR(3)
 
 
 
 
DUF3652(2)
 
 
Geminin(2)
 
 
BioAssay Types:
Literature(62)
 
 
 
 
Confirmatory(58)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(56)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 64    Data Row: 133   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26757474]
Potency 1.7783qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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2
[SID144205632]
Potency 4.2172qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID144205632]
Potency 4.2172qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID144205632]
Potency 4.2172qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID144205632]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID144205632]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID144205632]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID26757474]
Potency 5.6234Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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9
[SID26757474]
Potency 5.6234Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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10
[SID26757474]
Potency 5.6234Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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11
[SID26757474]
Potency 5.6234Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID26757474]
Potency 8.9125qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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13
[SID26757474]
Potency 8.9125qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation [AID492961, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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14
[SID26757474]
Potency 10qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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15
[SID26757474]
Potency 28.6954S16 Schwann cell viability assay (CellTiter-Glo assay) [AID624031, Type: confirmatory]
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16
[SID144205632]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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17
[SID144205632]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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18
[SID144205632]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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19
[SID144205632]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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20
[SID144205632]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
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21
[SID144205632]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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22
[SID144205632]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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23
[SID144205632]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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24
[SID26757474]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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25
[SID26757474]
Potency 35.4813qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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26
[SID144205632]
Potency 50.1187qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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27
[SID26757474]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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28
[SID26757474]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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29
[SID26757474]
Potency S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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30
[SID26757474]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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31
[SID26757474]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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32
[SID26757474]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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33
[SID26757474]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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34
[SID26757474]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]MLL gene product [Homo sapiens] [gi:56550039]
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35
[SID26757474]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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36
[SID26757474]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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37
[SID26757474]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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38
[SID26757474]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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39
[SID26757474]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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40
[SID26757474]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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41
[SID26757474]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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42
[SID26757474]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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43
[SID26757474]
Potency qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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44
[SID26757474]
Potency qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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45
[SID26757474]
Potency qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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46
[SID26757474]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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47
[SID26757474]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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48
[SID144205632]
Potency qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]NFKB1 gene product [Homo sapiens] [gi:34577122]
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49
[SID144205632]
Potency qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]NFKB1 gene product [Homo sapiens] [gi:34577122]
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50
[SID144205632]
Potency qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]NFKB1 gene product [Homo sapiens] [gi:34577122]
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