Camptothecin (CID 24360) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(914)
 
 
Inactive(610)
 
 
Inconclusive(169)
 
 
Unspecified(649)
 
 
Top Targets:
Topoisomer IB..(67)
 
 
 
 
p450(31)
 
 
 
 
 
7TM GPCR Srx(26)
 
 
 
 
7TM GPCR Srsx(15)
 
 
 
 
PLN02808(13)
 
 
 
BioAssay Types:
Literature(1246)
 
 
 
 
 
Confirmatory(590)
 
 
 
 
 
Screening(187)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
IC50(632)
 
 
 
 
 
Potency(405)
 
 
 
 
 
EC50(27)
 
 
 
 
Kd(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2060    Data Row: 2342   Total Pages: 47   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168388]
IC50 4e-06Cytotoxicity against human RPMI-8240 cells [AID331450, Type: Literature]
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2
[SID103168388]
IC50 4e-06Cytotoxicity against human P388 cells [AID331452, Type: Literature]
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3
[SID103168388]
EC50 0.00015Concentration required to inhibit growth of SW620 (human colon cancer) cells in the presence of 10 uM of Compound 2e [AID246473, Type: Literature]
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4
[SID103168388]
IC50 0.00056Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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5
[SID103168388]
IC50 0.00083Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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6
[SID103168388]
IC50 0.00084Inhibitory concentration against CEM cell growth after incubation in liquid medium for 72 h [AID248046, Type: Literature]
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7
[SID103168388]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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8
[SID103168388]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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9
[SID103168388]
IC50 0.001Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay [AID586347, Type: Literature]
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10
[SID103168388]
IC50 0.00112Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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11
[SID103168388]
EC50 0.0012Concentration required to inhibit growth of SW620 (human colon cancer) cells [AID246181, Type: Literature]
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12
[SID103168388]
IC50 0.00132Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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13
[SID103168388]
IC50 0.0014Growth inhibition of human Jurkat cells after 96 hrs [AID315648, Type: Literature]
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14
[SID103168388]
IC50 0.00141Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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15
[SID103168388]
GI50 0.0015Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay [AID320438, Type: Literature]
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16
[SID103168388]
IC50 0.0016Cytotoxicity against human MCF7 cells by SRB assay [AID604716, Type: Literature]
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17
[SID103168388]
IC50 0.0016Cytotoxicity against human MCF7 cells by SRB assay [AID664756, Type: Literature]
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18
[SID103168388]
GI50 0.0017Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID320437, Type: Literature]
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19
[SID103168388]
ED50 0.002Cytotoxicity against human LNCAP cells by sulforhodamine B assay [AID306997, Type: Literature]
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20
[SID103168388]
GI50 0.002Growth inhibition of human CEM cells by Alamar blue assay [AID307323, Type: Literature]
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21
[SID103168388]
IC50 0.002Cytotoxicity against human imitinib-resistant K562 cells by MTT assay [AID477976, Type: Literature]
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22
[SID103168388]
IC50 0.002Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay [AID430795, Type: Literature]
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23
[SID103168388]
IC50 0.002Cytotoxicity against imatinib-resistant human K562 cells after 72 hrs by MTT assay [AID492163, Type: Literature]
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24
[SID103168388]
IC50 0.002Cytotoxicity against human NCI-H460 cells incubated for 3 days by SRB assay [AID677135, Type: Literature]
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25
[SID103168388]
EC50 0.0021Antiproliferative activity against human SW620 cells by soft agar assay [AID294076, Type: Literature]Serine/threonine-protein kinase Chk1 [gi:317373343]
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26
[SID103168388]
EC50 0.0021Antiproliferative activity against human SW620 cells by soft agar assay [AID294076, Type: Literature]Serine/threonine-protein kinase Chk1 [gi:317373343]
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27
[SID103168388]
IC50 0.00221Cytotoxic activity against human neuroblastoma IMR32 cells which over-express somatostatin receptors [AID91553, Type: Literature]Somatostatin receptor type 1 [gi:401124]
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28
[SID103168388]
ID50 0.0024Compound was tested in vitro for cytotoxicity against VM46 subline of HCT116 (taxol-sensitive) at a drug concentration producing 50% inhibition of colony formation [AID217357, Type: Literature]
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29
[SID103168388]
ID50 0.0028Compound was tested in vitro for cytotoxicity against HCT116, human colon cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation [AID81704, Type: Literature]
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30
[SID103168388]
IC50 0.003Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay [AID430796, Type: Literature]
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31
[SID103168388]
IC50 0.003Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay [AID430794, Type: Literature]
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32
[SID103168388]
IC50 0.003Antiproliferative activity against human CCRF-CEM cells by MTT assay [AID290198, Type: Literature]
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33
[SID103168388]
IC50 0.003Antiproliferative activity against human CCRF-SB cells by MTT assay [AID290200, Type: Literature]
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34
[SID103168388]
IC50 0.003Cytotoxicity against human KB cells after 4 days by MTT assay [AID343612, Type: Literature]
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35
[SID103168388]
IC50 0.003Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay [AID678077, Type: Literature]
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36
[SID103168388]
CC50 0.003Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay [AID675391, Type: Literature]
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37
[SID103168388]
IC50 0.003Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay [AID623561, Type: Literature]
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38
[SID103168388]
CC50 0.003Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay [AID642198, Type: Literature]
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39
[SID103168388]
IC50 0.0031Antiproliferative activity measured against MCF-7-mdr cells. [AID103947, Type: Literature]
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40
[SID103168388]
ED50 0.0032Cytotoxicity against human MCF7 cells by sulforhodamine B assay [AID306996, Type: Literature]
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41
[SID103168388]
ED50 0.0032Cytotoxicity against human 1A9 cells by sulforhodamine B assay [AID306994, Type: Literature]
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42
[SID103168388]
EC50 0.0036Cytotoxicity against human KB cells [AID289106, Type: Literature]
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43
[SID103168388]
ID50 0.0038Compound was tested in vitro for cytotoxicity against PC-3, human prostate cancer cells (taxol-sensitive) at a drug concentration producing 50% inhibition of colony formation [AID156178, Type: Literature]
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44
[SID103168388]
ID50 0.0039Compound was tested in vitro for cytotoxicity against MCF-7ADR, human breast cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation [AID103243, Type: Literature]
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45
[SID103168388]
IC50 0.004Antiproliferative activity against human MT4 cells by MTT assay [AID290197, Type: Literature]
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46
[SID103168388]
IC50 0.004Cytotoxicity against human A2780 cells after 72 hrs by MTS method [AID332201, Type: Literature]
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47
[SID103168388]
IC50 0.004Cytotoxicity against human A549 cells after 48 hrs [AID384118, Type: Literature]
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48
[SID103168388]
IC50 0.004Cytotoxicity against human RPMI8402 cells by MTT method [AID409901, Type: Literature]
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49
[SID103168388]
IC50 0.004Cytotoxicity against mouse P388 cells by MTT method [AID409904, Type: Literature]
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50
[SID103168388]
IC50 0.004Cytotoxicity against human RPMI8402 cells after 4 days by MTT method [AID414754, Type: Literature]
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